Atypical Escherichia Coli in Urinary Tract Infection

Bhat, Kamalakshi G.; Bhat, Minakshi

doi:10.1177/004947559502500313

Cited by 4 publications

(3 citation statements)

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“…This rate is similar to results reported from Maroco (63%) [12], Ethiopia (60%) [13], but higher from studies in Equatorial Guinea (55%) [14], Nigeria (37%) [15] and Ghana (37%) [16]. The rate of lactose non fermenting E. coli urinary isolates from this study was 21%, which is similar to the study authored by Chang (about 20%) [17] and more higher than studies of Bhat (about 13%) [18], Bajapai (4%) [19].…”

Section: Discussionsupporting

confidence: 88%

Multi-Drug Resistance Pattern of Lactose Non-Fermenting Escherichia coli as Causative Agent of Urine Tract Infections in Luanda, Angola

Shatalov¹

2019

OJMM

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This prospective study was carried out to assess the sensitivity and resistance pattern of lactose non-fermenting Escherichia coli from July 2018 to December 2018 in the Laboratory of Microbiology at Luanda Medical Center, Angola. Out of 1170 patient, a total of 120 urine specimens infected with Escherichia coli (>10 5 CFU/ml) were collected according to the routine protocol of urinalysis. Among these 120 isolates, 25 (21%) isolates were determined as "atypical", lactose non-fermenting E. colis trains. The twenty-five lactose non-fermenting Escherichia coli strains isolated from urine samples in Luanda Medical Center were declared as Multiple Drugs-Resistant strains with high resistance to Cefalexine (100%), Cefuroxime (100%), Ceftriaxone (92%), Gentamycin (92%), Ciprofloxacin (72%) and Amoxiciclin/Clavulanic (80%). The alarming resistance level to the first-choice drugs for the treatment of urinary tract infections caused by non-fermentative lactose E. coli was observed.

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Section: Discussionsupporting

confidence: 88%

Multi-Drug Resistance Pattern of Lactose Non-Fermenting Escherichia coli as Causative Agent of Urine Tract Infections in Luanda, Angola

Shatalov¹

2019

OJMM

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“…This ratio has been proven to be correct by the study of Barcaite et al from Lithuania, during which the study group screened pregnant women and neonates for Group B Streptococcus and E. coli colonization (Barcaite et al 2012). In consecutive studies from India (starting in 1995), Bhat et al showed that 12.4% of urinary E. coli isolates are lactose non-fermenters (Bhat and Bhat 1995), while in studies with similar settings, Raksha et al (in 2003) (Raksha et al 2003), Radha et al (in 2010) (Radha and Jeya 2010) and Bajpai et al (in 2016) (Bajpai et al 2016) detected lac-E. coli in 9.0%, 6.3% and 3.6% of urine samples, respectively. Kaczmarek et al characterized n = 58 lac-and lac + E. coli bacteria isolated from pregnant women and neonates in Poland, using phenotypic and genotypic methods; in their report, lac-isolates showed higher levels of resistance to ticarcillin and ticarcillin/clavulanic acid, while no difference was seen in the number of genes carried for virulence factors (Kaczmarek et al 2017;Kaczmarek et al 2011).…”

Section: Antibiotic Susceptibility Resultsmentioning

confidence: 98%

Differential epidemiology and antibiotic resistance of lactose-fermenting and non-fermenting Escherichia coli: Is it just a matter of taste?

et al. 2020

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Urinary tract infections (UTIs) are some of the most common infections affecting humans worldwide. Occurrence of atypical, lactose non-fermenting, biochemically "inactive" strains of E. coli in clinical material has been described in the literature, which may cause a significant diagnostic challenge. The present retrospective microbiological study was carried out using isolates and data collected between January 1, 2013, and December 31, 2017, at the Institute of Clinical Microbiology. n = 24,285 positive urine samples were noted during the study period, out of which, samples positive for either lac + and lacE. coli were included in the analysis. E. coli represented n = 7075 (55.8% ± 4.6%) of outpatient and n = 4916 (42.4% ± 3.6%) of inpatient isolates. n = 401 (3.3%; 80.2 ± 14.6/year) lacE. coli isolates were identified from urinary tract infections. The ratio of lacE. coli isolates was significantly higher in outpatient samples (262 vs. 139). Resistance levels of lac-isolates for antibiotics commonly used for treating UTIs were significantly higher for both inpatient and outpatient isolates: norfloxacin, ciprofloxacin, fosfomycin and nitrofurantoin. It is essential to pay attention to the presence of lac-strains, and their omission from clinical material during diagnostic procedures may have significant consequences for epidemiological studies and therapy.

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“…Altered phenotypes could be due to an altered genetic makeup. Bhat et al [9] studied 210 E. coli strains isolated from the urine and found 26 (12.4%) to be atypical. In their study of the 26 atypical urinary isolates, 12% were hemolytic and three had hydrophobicity (< 0.156) and were MRHA positive and all the atypical E.coli had one or the other virulence marker, indicating that an atypical phenotype probably contributed to their virulence.…”

Section: Discussionmentioning

confidence: 99%

An Approach to Uropathogenic Escherichia Coli in Urinary Tract Infections

Ranjan

Chakraborty

et al. 2010

J Lab Physicians

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Purpose:To study the occurrence and characterization of Uropathogenic Escherichia Coli (UPEC) in cases with urinary tract infections.Materials and Methods:A total of 220 symptomatic cases from urinary tract infections and 50 stool samples from apparently healthy individuals were included. The colonies identified as Escherichia Coli were screened for virulence factors, that is, hemolysin, Mannose Resistant and Mannose Sensitive Hemagglutination (MRHA, MSHA), Cell surface hydrophobicity, and Serum resistance.Results:Among the 220 cases 91 (41.36%) were hemolytic, 68 (30.90%) showed MRHA, 58 (26.36%) were cell surface hydrophobicity positive, and 72 (32.72%) were serum-resistant. In 50 controls, three (6%) were hemolytic, six (12%) showed MRHA, nine (18%) showed cell surface hydrophobicity, and 12 (24%) were serum-resistant. The difference between cases and controls for hemolysis and MRHA were significant (P<0.001 and P<0.01, respectively). A total of 14 atypical E. coli were isolated from the urine and all showed the presence of one or the other virulence markers. Out of the 18 mucoid E.coli isolated, 10 were serum-resistant.Conclusions:The present study revealed that out of 220 urinary isolates, 151 could be labeled as UPEC.

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Atypical Escherichia Coli in Urinary Tract Infection

Cited by 4 publications

References 1 publication

Multi-Drug Resistance Pattern of Lactose Non-Fermenting <i>Escherichia coli</i> as Causative Agent of Urine Tract Infections in Luanda, Angola

Multi-Drug Resistance Pattern of Lactose Non-Fermenting <i>Escherichia coli</i> as Causative Agent of Urine Tract Infections in Luanda, Angola

Differential epidemiology and antibiotic resistance of lactose-fermenting and non-fermenting Escherichia coli: Is it just a matter of taste?

An Approach to Uropathogenic Escherichia Coli in Urinary Tract Infections

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Atypical Escherichia Coli in Urinary Tract Infection

Cited by 4 publications

References 1 publication

Multi-Drug Resistance Pattern of Lactose Non-Fermenting &lt;i&gt;Escherichia coli&lt;/i&gt; as Causative Agent of Urine Tract Infections in Luanda, Angola

Multi-Drug Resistance Pattern of Lactose Non-Fermenting &lt;i&gt;Escherichia coli&lt;/i&gt; as Causative Agent of Urine Tract Infections in Luanda, Angola

Differential epidemiology and antibiotic resistance of lactose-fermenting and non-fermenting Escherichia coli: Is it just a matter of taste?

An Approach to Uropathogenic Escherichia Coli in Urinary Tract Infections

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Multi-Drug Resistance Pattern of Lactose Non-Fermenting <i>Escherichia coli</i> as Causative Agent of Urine Tract Infections in Luanda, Angola

Multi-Drug Resistance Pattern of Lactose Non-Fermenting <i>Escherichia coli</i> as Causative Agent of Urine Tract Infections in Luanda, Angola