Atypical Linear IgA Dermatosis Revealing Angioimmunoblastic T-Cell Lymphoma

Skin lesions and neutrophilic leukemoid reaction in a patient with angioimmunoblastic T‐cell lymphoma: a case report and review of the literature

“…Two cases of vesicles (one is pruritic papulovesicular (prurigo‐like) lesion and the other is a pale erythematous eruption and violaceous plaques with bullae containing pale yellow exude.) were reported but they are apparently different from our case .…”

“…Skin lesions in AITL usually accompany pruritus . Typical lesions are usually a generalized morbilliform or maculopapular eruptions on the trunk mimicking toxic erythema . In the literature, uncommon skin lesions of AITL are mostly described in case reports or review articles (Table ).…”

Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan

“…21,22 Leukocytoclastic vasculitis with IgA deposits and atypical linear IgA dermatosis have been reported in patients with AITL. 21,22 A recent biologic finding has found that TGF-␤1 and IL-21, produced by T follicular helper cells, are related to the differentiation of IgA-plasmablasts. IgA-plasmablasts induced by neoplastic T follicular helper cells in patients with AITL might produce excessive serum IgA.…”

IgA Paraneoplastic Pemphigus in Angioimmunoblastic T-cell Lymphoma with Antibodies to Desmocollin 1, Type VII Collagen and Laminin 332

“…These cytokines, produced by tumour cells of AITL, may cause the abnormal immune reaction, which produces various autoantibodies. Intriguingly, all the skin conditions associated with AITL in previous reports were IgA-related diseases, including linear IgA bullous dermatosis, dermatitis herpetiformislike lesions and IgA-related leukocytoclastic vasculitis (8)(9)(10)(11). Al though the precise mechanism is unknown, AITL tumour cells may preferentially produce IgA autoantibodies to various bullous disease antigens.…”