Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

Thiede, Anja; Glerean, Enrico; Kujala, Teija; Parkkonen, Lauri

doi:10.1101/677674

Cited by 6 publications

(8 citation statements)

References 95 publications

(113 reference statements)

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“…7, sensors with higher ISC were located near the visual and audio cortices, which reportedly displayed high ISC during movie watching in previous studies 14,32–34 . In particular, the high ISC predominantly occurred in the delta, theta, and alpha bands, consistent with previous studies 14,33,34 . Together, the dataset demonstrated good validity in detecting ISC.…”

Section: Methodssupporting

confidence: 92%

A studyforrest extension, MEG recordings while watching the audio-visual movie “Forrest Gump”

Liu

Dai

Xie

et al. 2021

Preprint

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Naturalistic stimuli, such as movies, are being increasingly used to map brain function because of their high ecological validity. The pioneering studyforrest and other naturalistic neuroimaging projects have provided free access to multiple movie-watching functional magnetic resonance imaging (fMRI) datasets to prompt the community for naturalistic experimental paradigms. However, sluggish blood-oxygenation-level-dependent fMRI signals are incapable of resolving neuronal activity with the temporal resolution at which it unfolds. Instead, magnetoencephalography (MEG) measures changes in the magnetic ﬁeld produced by neuronal activity and is able to capture rich dynamics of the brain at the millisecond level while watching naturalistic movies. Herein, we present the first public prolonged MEG dataset collected from 11 participants while watching the 2 h long audio-visual movie "Forrest Gump". Minimally preprocessed data was also provided to facilitate the use. As a studyforrest extension, we envision that this dataset, together with fMRI data from the studyforrest project, will serve as a foundation for exploring the neural dynamics of various cognitive functions in real-world contexts.

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Section: Methodssupporting

confidence: 92%

A studyforrest extension, MEG recordings while watching the audio-visual movie “Forrest Gump”

Liu

Dai

Xie

et al. 2021

Preprint

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show abstract

“…In a sample of children and adolescents spanning ages 7–21 years, Gruskin et al (2020) report that patterns and severity of depression symptoms are linked to brain responses during an emotionally evocative animated clip, but only in adolescents, suggesting that these idiosyncratic responses emerge over the course of development. Finally, in a study of individuals with dyslexia, ISC calculated from MEG envelope time series correlated with similarity in phonological processing, technical reading, and working memory ( Thiede et al, 2019 ). Encouragingly, these studies show that there is meaningful—i.e., behaviorally relevant—structure in idiosyncratic responses to naturalistic stimuli.…”

Section: Existing Work On Isc and Individual Differencesmentioning

confidence: 99%

Idiosynchrony: From shared responses to individual differences during naturalistic neuroimaging

et al. 2020

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Two ongoing movements in human cognitive neuroscience have researchers shifting focus from group-level inferences to characterizing single subjects, and complementing tightly controlled tasks with rich, dynamic paradigms such as movies and stories. Yet relatively little work combines these two, perhaps because traditional analysis approaches for naturalistic imaging data are geared toward detecting shared responses rather than between-subject variability. Here, we review recent work using naturalistic stimuli to study individual differences, and advance a framework for detecting structure in idiosyncratic patterns of brain activity, or “idiosynchrony”. Specifically, we outline the emerging technique of inter-subject representational similarity analysis (IS-RSA), including its theoretical motivation and an empirical demonstration of how it recovers brain-behavior relationships during movie watching using data from the Human Connectome Project. We also consider how stimulus choice may affect the individual signal and discuss areas for future research. We argue that naturalistic neuroimaging paradigms have the potential to reveal meaningful individual differences above and beyond those observed during traditional tasks or at rest.

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“…ISC is a simple yet effective way to reliably extract the shared brain responses to complex naturalistic stimuli across individuals 58 . ISC was originally developed for fMRI data analysis but has also been applied to other neuroimaging modalities such as EEG [94][95][96][97][98] , MEG [99][100][101] .…”

Section: Inter-subject Correlation (Isc)mentioning

confidence: 99%

Minimal functional alignment of ventromedial prefrontal cortex intracranial EEG signals during naturalistic viewing

Xie

Cheong

Manning

et al. 2021

Preprint

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The ventromedial prefrontal cortex (vmPFC) has been thought to play an important role in processing endogenous information such as generating subjective affective meaning. Unlike sensory cortex, which processes exogenous information about the external world similarly across individuals, prior work has posited that vmPFC activity may be idiosyncratic to each individual, even when exposed to the same external stimulus. In this study, we recorded local field potentials (LFPs) from intracranial stereo electrodes implanted in patients with intractable epilepsy while they watched an emotionally engaging television show episode and evaluated temporal synchronization of these signals across participants in auditory cortex and vmPFC. Overall, we observed markedly lower intersubject synchronization of signals recorded from electrodes implanted in vmPFC compared to auditory cortex. A subset of patients, however, appeared to share similar vmPFC states during the more emotionally salient scenes. This work suggests that the vmPFC is involved in processing affective responses to ongoing experience in a state-like manner, but the specific states and temporal sequences are idiosyncratic to each individual, even when viewing the same television episode.

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Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

Cited by 6 publications

References 95 publications

A studyforrest extension, MEG recordings while watching the audio-visual movie “Forrest Gump”

A studyforrest extension, MEG recordings while watching the audio-visual movie “Forrest Gump”

Idiosynchrony: From shared responses to individual differences during naturalistic neuroimaging

Minimal functional alignment of ventromedial prefrontal cortex intracranial EEG signals during naturalistic viewing

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