Atypical Metastatic Presentations in Colorectal Cancer: A Case Series

Rogers, Jane E.; Ohinata, Aki; Dasari, Arvind; Eng, Cathy

doi:10.1016/j.clcc.2013.11.005

Cited by 10 publications

(9 citation statements)

References 10 publications

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“…Like tumors in general, these too are formed as a result of the abnormal and uncontrolled division of cells. The causes of colorectal cancer are mostly unknown, although it may be inherited or genetically unrelated [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer

Bhaumik

Gopalakrishnan

Kamaraj

et al. 2014

The Scientific World Journal

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Cancer is a complex genetic disorder, characterised by uncontrolled cell proliferation and caused by altered expression of oncogenes and tumour suppressor genes. When cell proliferation pertains to colon, it is called colorectal cancer. Most of colorectal cancer causing genes are potential targets for the miRNA (microRNA) that bind to 3′UTR (untranslated regions) of mRNA and inhibit translation. Mutations occurring in miRNA binding regions can alter the miRNA, mRNA combination, and can alter gene expression drastically. We hypothesized that 3′UTR mutation in miRNA binding site could alter the miRNA, mRNA interaction, thereby altering gene expression. Altered gene expression activity could promote tumorigenesis in colon. Therefore, we formulated a systematic in silico procedure that integrates data from various databases, followed rigorous selection criteria, and identified mutations that might alter the expression levels of cancer causing genes. Further we performed expression analysis to shed light on the potential tissues that might be affected by mutation, enrichment analysis to find the metabolic functions of the gene, and network analysis to highlight the important interactions of cancer causing genes with other genes to provide insight that complex network will be disturbed upon mutation. We provide in silico evidence for the effect of these mutations in colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer

Bhaumik

Gopalakrishnan

Kamaraj

et al. 2014

The Scientific World Journal

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“…Colorectal cancer development in patients with IBD has been shown to correlate with duration and extent of the disease . As a result, dysplasia surveillance programs starting within 8 years after IBD diagnosis, are currently recommended across the world .…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26][27][28][29][30] This Colorectal cancer development in patients with IBD has been shown to correlate with duration and extent of the disease. [31][32][33] As a result, dysplasia surveillance programs starting within 8 years after IBD diagnosis, are currently recommended across the world. 32,34,35 Despite this more intensive follow-up, in this study, half of the patients…”

Section: Patterns Of Recurrencementioning

confidence: 99%

The prognosis of colorectal cancer liver metastases associated with inflammatory bowel disease: An exploratory analysis

Margonis

Buettner

Andreatos

et al. 2018

Journal of Surgical Oncology

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Background and Objectives In contrast with sporadic colorectal cancer liver metastases (CRLM), inflammatory bowel disease (IBD)‐related CRLM have not been studied to date. Methods Patients who underwent resection for IBD‐related and sporadic CRLM from 2000 to 2015 were identified from an international registry and matched for pertinent prognostic variables. Overall survival (OS) and recurrence‐free survival (RFS) were subsequently assessed. Results Twenty‐eight patients had IBD‐related CRLM. Synchronous extrahepatic disease was more common in IBD‐related CRLM patients than patients with sporadic CRLM (28.6% vs 8.3%; P < 0.001), most commonly located in the lungs. In multivariable analysis, IBD did not have a significant influence on OS ( P = 0.835), and had a hazard ratio (HR) close to 1 (HR, 0.95; 95% confidence interval [CI], 0.57‐1.57). IBD was also not associated with inferior RFS (HR, 1.07; 95%CI, 0.68‐1.68; P = 0.780). Among patients with IBD‐related CRLM, 9(50%) had isolated intrahepatic recurrence and 8(44.4%) isolated extrahepatic recurrence, while only 1(5.6%) developed combined recurrence. Of those who experienced recurrence after resection of IBD‐related CRLM, 10 had their recurrence treated with curative intent. Conclusions Patients with IBD‐related CRLM had similar survival compared with patients with sporadic CRLM, even though they more often present with extrahepatic disease. In addition, patients with IBD‐related CRLM may experience patterns of recurrence different from patients with sporadic CRLM.

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“…Clinically, the metastatic lesions do not have a uniformly characteristic appearance and they are often misdiagnosed mimicking simple cysts or benign connective tissue lesions such as pyogenic granuloma, granular cell tumor, a benign cyst, and benign subcutaneous nodule [ 18 ]. Therefore, atypical or persistent nodular lesions in patients with a history of systemic malignancy should be considered for biopsy to rule out metastasis [ 11 ]. Cutaneous involvement of colorectal carcinoma seems to favor sites of previous incisions, as a colostomy site, but sometimes the skin of scalp or face may be affected, and in these cases, the nodules have cystic appearance.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metastatic Adenocarcinoma of the Colon to the Scalp

et al. 2015

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Cutaneous metastases from colorectal cancer are relatively uncommon presenting in fewer than 5% of patients but they are very important to recognize as they signify disseminated disease and poor prognosis. We describe a case a 62-year-old patient diagnosed with scalp metastasis during his systemic chemotherapy treatment for a colorectal carcinoma stage IVb who underwent excisional biopsy of the metastatic lesion. The identification of cutaneous metastases from colorectal cancer can radically alter therapeutic plans as they typically indicate a wide spread disease. Although they can be observed at any stage of malignancy, early recognition can lead to accurate and prompt diagnosis and timely treatment.

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Atypical Metastatic Presentations in Colorectal Cancer: A Case Series

Cited by 10 publications

References 10 publications

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer

The prognosis of colorectal cancer liver metastases associated with inflammatory bowel disease: An exploratory analysis

Cutaneous Metastatic Adenocarcinoma of the Colon to the Scalp

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