Atypical pulmonary alveolar proteinosis presenting as a mixed nodular ground-glass opacity with focal mucinosis mimicking lung cancer

Shinohara, Tsutomu; Hino, Hitoshi; Imanishi, Shino; Naruse, Keishi; Ohtsuki, Yuji; Ogushi, Fumitaka

doi:10.21037/jtd.2018.08.77

Cited by 2 publications

(1 citation statement)

References 21 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,3 Reports of localized or solitary PAP are extremely rare, and to the best of our knowledge, only 6 cases have been reported, including the present case (Table 1). [4][5][6][7][8] Among these cases, the crazy-paving pattern was observed in only 2. The anti-GM-CSF antibody was measured in only 3 of the 6 cases, 2 of which were positive.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Localized Pulmonary Alveolar Proteinosis With Part-solid Ground-glass Nodule-like Appearance

Koga,

Chikasue,

Sumi

et al. 2023

Journal of Thoracic Imaging

View full text Add to dashboard Cite

P ulmonary alveolar proteinosis (PAP) is a general term for diseases that cause abnormal accumulation of acidophilic granular protein, a surfactant-derived substance. Accumulation mainly occurs in the alveolar spaces, usually with bilateral or diffuse distribution. Localized or solitary PAP is very rare, and differentiating it from pulmonary adenocarcinoma is difficult. We report a case in which the natural history of localized PAP was followed for 2 years.

show abstract

Section: Discussionmentioning

confidence: 99%

A Rare Case of Localized Pulmonary Alveolar Proteinosis With Part-solid Ground-glass Nodule-like Appearance

Koga,

Chikasue,

Sumi

et al. 2023

Journal of Thoracic Imaging

View full text Add to dashboard Cite

show abstract

Pulmonary Alveolar Proteinosis-Like Pathological Changes Mimicking Lung Adenocarcinoma in Situ

Hayasaka,

Fujita,

Eba

et al. 2024

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

An enlarging ground-glass nodule (GGN) in the lungs closely resembles the characteristic appearance of a well differentiated lung adenocarcinoma or adenocarcinoma in situ (AIS).Herein, we present an unusual case characterized by clinical features suggestive of AIS but pathologically confirmed as exhibiting pulmonary alveolar proteinosis (PAP)-like changes. Patients with enlarging pure GGNs warrant consideration for diagnostic and curative surgery. While a considerable proportion of such cases receives a pathological diagnosis of lung malignancy, it is imperative to consider alternative benign conditions in the differential diagnosis, such as PAP-like changes.

show abstract

Atypical pulmonary alveolar proteinosis presenting as a mixed nodular ground-glass opacity with focal mucinosis mimicking lung cancer

Cited by 2 publications

References 21 publications

A Rare Case of Localized Pulmonary Alveolar Proteinosis With Part-solid Ground-glass Nodule-like Appearance

A Rare Case of Localized Pulmonary Alveolar Proteinosis With Part-solid Ground-glass Nodule-like Appearance

Pulmonary Alveolar Proteinosis-Like Pathological Changes Mimicking Lung Adenocarcinoma in Situ

Contact Info

Product

Resources

About