Atypical squamous cells of undetermined significance—rule out high‐grade squamous intraepithelial lesion: Cytopathologic characteristics and clinical correlates

Alli, Patricia M.; Ali, Syed Z.

doi:10.1002/dc.10286

Cited by 53 publications

(55 citation statements)

References 6 publications

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“…Furthermore, it is of some concern that 136 patients (18% of ASC-US women and 1.7% of ASC-H) had only cytologic sampling without histologic examination, a fact which may reflect a lack of knowledge about the appropriate follow-up of these equivocal Pap tests. However, modest decreases in rates of HSIL biopsy findings among ASC-H are also reported by other investigators (Alli and Ali, 2003;Bansal et al, 2012) suggesting that the diagnostic thresholds and disease Table 6. High-risk HPV positivity among ASC-US and ASC-H in different series DOI:http://dx.doi.org/10.7314/APJCP.2012.13.7…”

Section: Discussionmentioning

confidence: 59%

Follow up of Atypical Squamous Cell Pap Smears in Iraqi Women

Pity¹,

Shamdeen²,

Wais³

2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 59%

Follow up of Atypical Squamous Cell Pap Smears in Iraqi Women

Pity¹,

Shamdeen²,

Wais³

2012

Asian Pacific Journal of Cancer Prevention

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“…This gives rise to higher prevalence than the reality of clinical practice, reaching values from 26% to 68%. [13][14][15]17,18 Another likely reason was that we included cases in which the diagnostic conclusion was reached during the follow-up, which lowers the prevalence of the disease. According to Sherman et al, 23 the imperfect sensitivity of colposcopy for detecting small or focal pre-invasive lesions reinforces the need for strict follow-up among individuals with ASC-H cytology without lesions visible from colposcopy.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,11,12 Cross-sectional studies evaluating the prevalence of CIN II and III among individuals with ASC-H cytology have found values between 26 and 68%. [13][14][15][16][17][18][19] There is some evidence that this prevalence is lower after the menopause. 15,17,20,21 …”

Section: Introductionmentioning

confidence: 99%

Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out

Cytryn¹,

Russomano

Camargo

et al. 2009

Sao Paulo Med. J.

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Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out Prevalência de neoplasia intra-epitelial cervical graus II/III e câncer cervical nas pacientes com diagnóstico citológico de células escamosas atípicas, quando não se pode excluir lesão intra-epitelial de alto grau (ASC-H)Andréa RESULTS:The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55%) and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764). Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83); P = 0.2786998). There were no uterine cervical cancer cases. CONCLUSION:The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions. RESUMO CONTEXTO E OBJETIVO:A última atualização do Sistema Bethesda dividiu a categoria de células escamosas atípicas de significado indeterminado (ASCUS) em ASC-US (de significado indeterminado) e ASC-H (quando não se pode excluir lesão intra-epitelial de alto grau). Os objetivos deste estudo foram medir a prevalência da lesão pré-invasiva (Neoplasia Intra-epitelial Cervical, NIC II/III) e câncer cervical, de pacientes que foram encaminhadas ao Instituto Fernandes Figueira (IFF), com citologia ASC-H e compará-la com os casos ASC-US. RESULTADOS: A prevalência de NIC II/III na citologia ASC-H foi de 19,29% (intervalo de confiança, IC 95% 9,05-29,55%) e o risco destas lesões foi maior entre as pacientes com citologia ASC-H comparado às pacientes com citologia ASC-US (razão de prevalência, RP = 10,42; IC 95% 2,39-45,47; P = 0,0000764). A lesão pré-invasiva na citologia ASC-H foi mais frequente abaixo dos 50 anos (RP = 2,67; IC 95% 0,38-18,83), P = 0,2786998. Não houve casos de câncer do colo do útero. TIPO DE ESTUDO E LOCAL:CONCLUSÕES: A prevalência de NIC II/III em pacientes com citologia ASC-H foi significativamente mais alta que a de ASC-US, e a divisão em subcategorias do diagnóstico ASC se mostrou com boa capacidade para discriminar a presença de lesões pré invasivas.

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“…In the recent study by Kingnate et al (2014), incidence of CIN 2-3/AIS and invasive lesion was 10.5% and 2.6%, respectively. In the literature, almost all studies evaluating histopathologic results of ASC-H smears were reported from North America where the incidence of cervical cancer appears to be relatively low (Alli and Ali, 2003;Louro et al, 2003;Selvaggi, 2003;Liman et al, 2005;Barreth et al, 2006;Saad et al, 2006;Srodon et al, 2006;McHale et al, 2007). The rate of underlying high-grade cervical lesion varied widely from 10% to 80%, in which less than 3.5% were invasive lesion (Alli and Ali, 2003;Louro et al, 2003;Selvaggi, 2003;Liman et al, 2005;Barreth et al, 2006;Saad et al, 2006;Srodon et al, 2006;McHale et al, 2007).…”

Section: Atypical Squamous Cells Cannot Exclude High-grade Squamous mentioning

confidence: 99%

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

Kietpeerakool¹,

Tangjitgamol²,

Srisomboon³

2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (16), 6489-6494 IntroductionCervical cancer remains the major health problem in Thailand and many other developing countries. This is mainly because of failure to initiate or sustain effective screening strategy. In recent population-based cancer registries, the highest incidence of cervical cancer in Thailand was noted in Chiang Mai with an average agestandardized incidence rate (ASR) of 28.9 per 100000, followed by Lampang (ASR, 22.4) and Bangkok (ASR, 20.9) (Moore et al., 2010).Although high-risk Human Papillomavirus (HR-HPV) test and HPV genotyping have certain role in cervical cancer screening nowadays, these tests are not widely available in developing countries. Cervical cytology is still the principal screening method. Subsequent management of abnormal cervical cytology to detect underlying cervical lesions is also important. Generally, management of abnormal cervical cytology depends on the risk of encountering high-grade cervical disease. However, the risks of high-grade cervical disease encountered in abnormal cervical cytology may vary among different regions of the world and across the country. Therefore, information regarding the incidence of significant cervical disease from different areas or populations is crucial for designing and implementing area-specific management approach. This review was conducted to evaluate the incidence of high-grade cervical diseases among Thai AbstractCervical cytology remains the principal screening method to detect pre-invasive and invasive cervical lesions. Management of abnormal cervical cytology depends on the risk of encountering a significant cervical lesion or high-grade cervical disease. These risks may vary in different areas across the country. Thus, determining the rate of significant cervical lesion associated with each type of abnormal cervical cytology in each area is of critical importance for designing area-specific management approach. This review was conducted to evaluate the rate of high-grade cervical disease among Thai women with abnormal cervical cytology. A relatively high incidence of underlying significant lesions including invasive disease was demonstrated even in those having only minimal smear abnormality. This baseline information is crucial and must be taken into consideration in management of women with abnormal cytological screening to achieve the goals of comprehensive cervical cancer control in Thailand.

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Atypical squamous cells of undetermined significance—rule out high‐grade squamous intraepithelial lesion: Cytopathologic characteristics and clinical correlates

Cited by 53 publications

References 6 publications

Follow up of Atypical Squamous Cell Pap Smears in Iraqi Women

Follow up of Atypical Squamous Cell Pap Smears in Iraqi Women

Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

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