Atypical white-matter microstructure in congenitally deaf adults: A region of interest and tractography study using diffusion-tensor imaging

Karns, Christina M.; Stevens, Caitlin; Dow, Mark W.; Schorr, Emily

doi:10.1016/j.heares.2016.07.008

Cited by 32 publications

(36 citation statements)

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“…In deaf individuals, studies suggest FA reductions of the fibers projecting through the splenium. This reduction was observed in native deaf signers (Karns et al, 2017), in both adolescent and adult sign language users Miao et al, 2013). Two studies reported similar white matter FA in the corpus callosum of deaf individuals and hearing participants, but also reported a decrease in AD Miao et al, 2013).…”

Section: Findings Related To Structures Involved In Multisensory Procmentioning

confidence: 75%

“…The vast majority of reviewed studies report reduced volume, density, and FA in fibers projecting to the primary auditory cortex (Heschl's gyrus), which is related to processing speech sounds. These changes are found in the left and right hemispheres (Emmorey et al, 2003;Smith et al, 2011;Miao et al, 2013;Hribar et al, 2014;Huang et al, 2015;Wu et al, 2016;Karns et al, 2017;Zheng et al, 2017). Two studies reported similar white matter volumes between native deaf and hearing individuals (Penhune et al, 2003;Leporé et al, 2010).…”

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 89%

“…Two studies reported similar white matter volumes between native deaf and hearing individuals (Penhune et al, 2003;Leporé et al, 2010). With regard to DTI, a reduction in FA was found to be related to an increase in RD Miao et al, 2013;Karns et al, 2017). One study reported no significant difference in RD and AD between deaf and hearing individuals (Hribar et al, 2014).…”

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 93%

“…These changes are found in both hemispheres. Regarding DTI indexes, a reduction in FA appears to be related to an increase in RD in deaf individuals compared with hearing peers ; Miao et al, 2013;Wu et al, 2016;Karns et al, 2017). One study reported equal RD and increased AD (Hribar et al, 2014).…”

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 98%

“…In the right hemisphere, the superior temporal gyrus is implicated in prosodic aspects of speech (Friederici, 2011). Reflected by several neuroimaging techniques, strong evidence supports the presence of white matter changes (reduced volume/density or a reduction in FA values) in the superior temporal gyrus of deaf individuals (Emmorey et al, 2003;Shibata, 2007;Kim et al, 2009Kim et al, , 2014Smith et al, 2011;Miao et al, 2013;Pénicaud et al, 2013;Hribar et al, 2014;Olulade et al, 2014;Huang et al, 2015;Wu et al, 2016;Karns et al, 2017;Zheng et al, 2017). These changes are found in both hemispheres.…”

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 99%

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The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes

et al. 2020

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Background: Auditory deprivation alters cortical and subcortical brain regions, primarily linked to auditory and language processing, resulting in behavioral consequences. Neuroimaging studies have reported various degrees of structural changes, yet multiple variables in deafness profiles need to be considered for proper interpretation of results. To date, many inconsistencies are reported in the gray and white matter alterations following early profound deafness. The purpose of this study was to provide the first systematic review synthesizing gray and white matter changes in deaf individuals. Methods: We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement in 27 studies comprising 626 deaf individuals. Results: Evidence shows that auditory deprivation significantly alters the white matter across the primary and secondary auditory cortices. The most consistent alteration across studies was in the bilateral superior temporal gyri. Furthermore, reductions in the fractional anisotropy of white matter fibers comprising in inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, and the subcortical auditory pathway are reported. The reviewed studies also suggest that gray and white matter integrity is sensitive to early sign language acquisition, attenuating the effect of auditory deprivation on neurocognitive development. Conclusions: These findings suggest that understanding cortical reorganization through gray and white matter changes in auditory and non-auditory areas is an important factor in the development of auditory rehabilitation strategies in the deaf population.

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Section: Findings Related To Structures Involved In Multisensory Procmentioning

confidence: 75%

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 89%

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 93%

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 98%

Section: Findings Related To Structures Involved In Auditory and Langmentioning

confidence: 99%

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The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes

et al. 2020

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Alterations of the cerebral microstructure in patients with noise‐induced hearing loss: A diffusion tensor imaging study

Huang,

Wang,

Zhang

et al. 2024

Brain and Behavior

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ObjectiveTo explore the changes in the cerebral microstructure of patients with noise‐induced hearing loss (NIHL) using diffusion tensor imaging (DTI).MethodOverall, 122 patients with NIHL (mild [MP, n = 79], relatively severe patients [including moderate and severe; RSP, n = 32], and undetermined [lost to follow‐up, n = 11]) and 84 healthy controls (HCs) were enrolled. All clinical data, including age, education level, hearing threshold, occupation type, noise exposure time, and some scale scores (including the Mini‐Mental State Examination [MMSE], tinnitus handicap inventory [THI], and Hamilton Anxiety Scale [HAMA]), were collected and analyzed. All participants underwent T1WI3DFSPGR and DTI, and tract‐based spatial statistics and region of interest (ROI) analysis were used for assessment.ResultsThe final sample included 71 MP, 28 RSP, and 75 HCs. The HAMA scores of the three groups were significantly different (p < .05). The noise exposure times, hearing thresholds, and HAMA scores of the MP and RSP were significantly different (p < .05). The noise exposure time was positively correlated with the hearing threshold and negatively correlated with the HAMA scores (p < .05), whereas the THI scores were positively correlated with the hearing threshold (p < .05). DTI analysis showed that all DTI parameters (fractional anisotropy [FA], axial diffusivity [AD], mean diffusivity [MD], and radial diffusivity [RD]) were significantly different in the left inferior longitudinal fasciculus (ILF) and left inferior fronto‐occipital fasciculus (IFOF) for the three groups (p < .05). In addition, the FA values were significantly lower in the bilateral corticospinal tract (CST), right fronto‐pontine tract (FPT), right forceps major, left superior longitudinal fasciculus (temporal part) (SLF), and left cingulum (hippocampus) (C‐H) of the MP and RSP than in those of the HCs (p < .05); the AD values showed diverse changes in the bilateral CST, left IFOF, right anterior thalamic radiation, right external capsule (EC), right SLF, and right superior cerebellar peduncle (SCP) of the MP and RSP relative to those of the HC (p < .05). However, there were no significant differences among the bilateral auditory cortex ROIs of the three groups (p > .05). There was a significant negative correlation between the FA and HAMA scores for the left IFOF/ILF, right FPT, left SLF, and left C‐H for the three groups (p < .05). There was a significant positive correlation between the AD and HAMA scores for the left IFOF/ILF and right EC of the three groups (p < .05). There were significantly positive correlations between the RD/MD and HAMA scores in the left IFOF/ILF of the three groups (p < .05). There was a significant negative correlation between the AD in the right SCP and noise exposure time of the MP and RSP groups (p < .05). The AD, MD, and RD in the left ROI were significantly positively correlated with hearing threshold in the MP and RSP groups (p < .05), whereas FA in the right ROI was significantly positively correlated with the HAMA scores for the three groups (p < .05).ConclusionThe changes in the white matter (WM) microstructure may be related to hearing loss caused by noise exposure, and the WM structural abnormalities in patients with NIHL were mainly located in the syndesmotic fibers of the temporooccipital region, which affected the auditory and language pathways. This confirmed that the auditory pathways have abnormal structural connectivity in patients with NIHL.

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Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss—Scientific and clinical challenges

Ratnanather

2019

WIREs Mechanisms of Disease

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There has been a spurt in structural neuroimaging studies of the effect of hearing loss on the brain. Specifically, magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) technologies provide an opportunity to quantify changes in gray and white matter structures at the macroscopic scale. To date, there have been 32 MRI and 23 DTI studies that have analyzed structural differences accruing from pre-or peri-lingual pediatric hearing loss with congenital or early onset etiology and postlingual hearing loss in pre-to-late adolescence. Additionally, there have been 15 prospective clinical structural neuroimaging studies of children and adolescents being evaluated for cochlear implants. The results of the 70 studies are summarized in two figures and three tables. Plastic changes in the brain are seen to be multifocal rather than diffuse, that is, differences are consistent across regions implicated in the hearing, speech and language networks regardless of modes of communication and amplification. Structures in that play an important role in cognition are affected to a lesser extent. A limitation of these studies is the emphasis on volumetric measures and on homogeneous groups of subjects with hearing loss.It is suggested that additional measures of morphometry and connectivity could contribute to a greater understanding of the effect of hearing loss on the brain. Then an interpretation of the observed macroscopic structural differences is given. This is followed by discussion of how structural imaging can be combined with functional imaging to provide biomarkers for longitudinal tracking of amplification.

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Atypical white-matter microstructure in congenitally deaf adults: A region of interest and tractography study using diffusion-tensor imaging

Cited by 32 publications

References 42 publications

The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes

The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes

Alterations of the cerebral microstructure in patients with noise‐induced hearing loss: A diffusion tensor imaging study

Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss—Scientific and clinical challenges

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