Atypisches Cogan-Syndrom als Differenzialdiagnose eines Hörsturzes

Background Cogan's syndrome (CS) is a rare autoimmune disorder characterized by non-syphilitic interstitial keratitis (IK) and Menière-like cochlear vestibular symptoms, which may also have systemic effects. Corticosteroids are first-line treatment. DMARDs and biologics have been used to treat ocular and systemic symptoms of CS. Case presentation This is a case of a 35-year-old female who reported hearing loss, eye redness and photophobia. Her condition progressed to a sudden sensorineural hearing loss, tinnitus, and constant vertigo accompanied by cephalea. CS was diagnosed after excluding other diseases. The patient still developed bilateral sensorineural hearing loss after receiving hormone, methotrexate, cyclophosphamide, and a variety of biological agents. Joint symptoms were relieved after treatment with a JAK inhibitor (tofacitinib), and hearing did not deteriorate further. Conclusions CS should be involved in the differential diagnosis of keratitis. Early identification and intervention of this autoimmune disease can minimize disability and irreversible damage.

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Cogan’s syndrome is more than just keratitis: a case-based literature review

Wang

Tang

Shao

et al. 2023

BMC Ophthalmol

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From precise diagnosis to effective treatment: a case report of atypical Cogan’s syndrome

Lou¹,

Li²

2023

Int J Ophthalmol

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Atypisches Cogan-Syndrom als Differenzialdiagnose eines Hörsturzes

Cited by 2 publications

References 30 publications

Cogan’s syndrome is more than just keratitis: a case-based literature review

Cogan’s syndrome is more than just keratitis: a case-based literature review

From precise diagnosis to effective treatment: a case report of atypical Cogan’s syndrome

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