Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

Xi, Juqun; Qian, Xiaodong; Qian, Kehong; Zhang, Wanying; He, Wen; Chen, Yan; Han, Jie; Zhang, Yuzhen; Yang, Xiangjun; Fan, Lei

doi:10.1039/c5tb00200a

Cited by 32 publications

(26 citation statements)

References 42 publications

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“…16,17 Xi et al developed Au nanoparticle (NP)-coated, polydopamine-modified, PLGA hybrid capsules for combined US imaging and high-intensity focused US therapy. 18 However, those agents could not identify target sites from molecular levels or combine with molecules with high specificity for an appropriately long time because high affinity-binding ligands on the surface of the agents were absent. Furthermore, few studies have been conducted to develop targeted Au-nanoshelled PLGA NPs for the early diagnosis of breast cancer or to investigate the biodistribution of Au-nanoshelled PLGA NPs in vivo.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent

Wan

et al. 2018

IJN

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BackgroundThe development of nanoscale molecularly targeted ultrasound contrast agents (UCAs) with high affinity and specificity is critical for ultrasound molecular imaging in the early detection of breast cancer.PurposeTo prospectively evaluate ultrasound molecular imaging with dual-targeted gold nanoshelled poly(lactide-co-glycolic acid) nanocapsules carrying vascular endothelial growth factor receptor type 2 (VEGFR2) and p53 antibodies (DNCs) in MCF-7 orthotopic mice model.MethodsDNCs were fabricated with an inner PLGA and outer gold nanoshell spherical structure. Its targeting capabilities were evaluated by confocal laser scanning microscopy (CLSM) and flow cytometry (FCM) in vitro. Contrast-enhanced ultrasound imaging (CEUS) with DNCs was evaluated qualitatively and quantitatively in vitro and in MCF-7 orthotopic mice model by two different systems. The biodistribution of NCs in mice was preliminary investigated. Differences were calculated by using analysis of variance.ResultsDNCs showed a well-defined spherical morphology with an average diameter of 276.90±110.50 nm. In vitro, DNCs exhibited high target specificities (79.01±5.63% vs. 2.11±1.07%, P<0.01; 75.54±6.58% vs. 5.21±3.12%, P<0.01) in VEGFR2- and p53-positive cells compared with control cells. In vivo, CEUS displayed a significantly higher video intensity in two systems using DNCs in comparison with non-targeted PLGA@Au NCs and single-targeted NCs. Biodistribution studies revealed that more DNCs in breast cancer tissue could be detected in mice than in other NCs (P<0.05).ConclusionDNCs were demonstrated to be novel dual-targeted UCAs and may have potential applications in early non-invasive visualization of breast cancer.

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Section: Introductionmentioning

confidence: 99%

Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent

Wan

et al. 2018

IJN

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“…14 The pharmacological effect will be maximized if the drug release from a microcapsule can be controlled by an external stimulus at a targeted site at a stipulated time, which will also help minimize side effects. The use of ultrasound, 15 change in pH, 16 and electric field 17 as stimuli have been reported in previous studies. Among others, laser-mediated methods are attractive in regard to spatial and temporal controllability.…”

Section: Introductionmentioning

confidence: 73%

Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

et al. 2016

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The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.

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“…Surface modification of PLGA nanoparticles with dopamine was further performed according to our previous work. 30 In this process, the PLGA nanoparticles were first dispersed in Tris-HCl buffer solution (pH 8.5), and then mixed with dopamine. Under weakly alkaline and aerobic conditions, dopamine molecules self-polymerized to form thin adherent PDA on surfaces of PLGA nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Mn<sup>2+</sup>-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

Yang

et al. 2017

IJN

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Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn 2+ -coordinated doxorubicin (DOX)-loaded poly(lactic- co -glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn 2+ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn 2+ -PDA@DOX/PLGA nanoparticles. In our system, Mn 2+ -PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn 2+ could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn 2+ -PDA@ DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties.

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Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

Cited by 32 publications

References 42 publications

Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent

Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent

Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

Mn<sup>2+</sup>-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

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