Audiological and vestibular function tests in hypothyroidism

Bhatia, Pradeep; Op, Gupta; Agrawal, Manindra; Mishr, S K

doi:10.1288/00005537-197712000-00014

Cited by 50 publications

(38 citation statements)

References 19 publications

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“…Observa-se ainda o comprometimento da condução do estímulo neural nas vias labirínticas centrais na falta do hormônio tireoideano 31 . Observamos que as alterações dos níveis de hormônios tireoideanos estão presentes em 13,6% de nosso grupo de estudo enquanto que na população essa porcentagem é de 10% 17,22 . Encontramos níveis semelhantes em pacientes portadores de zumbido 2 .…”

Section: Discussionunclassified

“…Sabe-se ainda que o hipotireoidismo pode ser responsável pela elevação dos níveis circulantes de lípides. Vários trabalhos experimentais têm demonstrado que tanto o órgão periférico como as vias labirínticas centrais podem ser acometidas pelas disfunções tireoideanas 5,17 . Em função da importância que adquirem as disfunções metabólicas no desencadeamento da sintomatologia labiríntica, resolvemos avaliar a prevalência dos distúrbios dos hidratos de carbono, lípides e hormônios tireoideanos em nossos pacientes portadores de síndromes vestibulares.…”

Section: Prevalency Of Metabolic Disorders In Dizzy Patientsunclassified

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Prevalência das alterações metabólicas em pacientes portadores de queixas vestibulares

Bittar¹,

Bottino²,

Zerati³

et al. 2003

Rev. Bras. Otorrinolaringol.

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FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Os autores avaliam a prevalência de alterações metabólicas em 325 pacientes que procuraram o Setor de Otoneurologia do Hospital das Clínicas da FMUSP com queixas vestibulares. Os pacientes foram consecutivamente atendidos entre janeiro de 1997 e janeiro de 2002. Foram avaliados os primeiros exames referentes ao protocolo clássico de investigação das tonturas, que compreende a dosagem de LDL colesterol, TSH, T3 e T4 e glicemia de jejum. As alterações encontradas foram então comparadas às observadas na população geral. As alterações mais significativas encontradas foram a elevação dos níveis de LDL colesterol, a presença de níveis alterados de hormônios tireoideanos e a maior freqüência do diabetes mellitus na população estudada. CONCLUSÃO: Conclui-se que é válida a investigação destes dados, visto que são mais freqüentes na população de risco e que a correta abordagem dessas alterações melhora o prognóstico e o controle da tontura.

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Section: Discussionunclassified

Section: Prevalency Of Metabolic Disorders In Dizzy Patientsunclassified

Prevalência das alterações metabólicas em pacientes portadores de queixas vestibulares

Bittar¹,

Bottino²,

Zerati³

et al. 2003

Rev. Bras. Otorrinolaringol.

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“…About 25% of patients with acquired hypothyroidism and 30-50% of patients with CH identified before the introduction of screening programs and treated late are thought to display hearing loss, which is partially reversed by TH replacement treatment (42,43,44,45,46). Hearing loss has also been reported in cases of endemic cretinism (47), in patients with TH resistance (48), and in patients with TH monocarboxylate transporter 8 (MCT8) abnormalities (49).…”

Section: Neurosensory Developmentmentioning

confidence: 99%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The early treatment of CH patients has successfully improved the prognosis and management of this disorder. Optimal treatment and management throughout the patient's life, beginning in the neonatal period, are required to ensure long-term health. Affected patients should be offered assessments of associated medical conditions and provided with accurate information about their condition throughout their lives, but particularly during the transition from pediatric to adult services. This review provides a summary of current knowledge about the long-term outcomes of these patients and appropriate management into early adulthood. We carried out a systematic search of the Medline database to identify relevant articles. Despite major improvements in prognosis, the impact of CH is clearly not uniform, and management should take into account a broader range of relevant indicators, including CH severity, associated comorbid conditions and the adequacy of treatment during childhood and adulthood. The early diagnosis and management of associated medical conditions, and better educational strategies to improve compliance with treatment, should improve the long-term prognosis. Further studies are required to explore changes with aging.

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“…Congenital and acquired hypothyroidism, development of the auditory system and hearing function Both non-genetic congenital and acquired hypothyroidism have been suggested to be causal to hearing loss (46,47) . In this section, the empirical evidence for this causality derived from animal and human studies is described.…”

Section: Genetic Factors Thyroid Metabolism and Auditory Functionmentioning

confidence: 99%

Iodine deficiency, thyroid function and hearing deficit: a review

Melse‐Boonstra

Mackenzie

2013

Nutr. Res. Rev.

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Iodine deficiency affects an estimated 241 million school-aged children in the world. Little is known about iodine deficiency in relation to auditory function, except for the fact that deaf-mutism is one of the features of cretinism. In the present review, we documented the scientific knowledge on the role of iodine and hypothyroidism in the auditory system. We found that ear development and hearing function depend on thyroid hormones. Multiple pathways are involved in this, including both inner ear morphology as well as neurological processes. Conductive as well as sensorineural hearing loss is found in studies with animals that were rendered hypothyroidic. In humans, auditory impairment is reported frequently in relation to hypothyroidism, ranging from mild disturbances to severe handicap. Auditory impairment has been related more explicitly to congenital hypothyroidism than to acquired hypothyroidism. The critical period for thyroid function-related hearing maturation is the first and second trimesters of pregnancy. Although only a limited number of studies have directly investigated the relationship between iodine deficiency and auditory function, most studies point toward an association. However, evidence from good randomised controlled trials is lacking. Inclusion of auditory outcomes in iodine supplementation studies is therefore to be recommended, especially for trials in pregnancy. Hearing deficit is an invisible abnormality, but has major consequences for educational and social skills if not detected. In view of this, auditory impairment should be mapped in iodine-deficient areas in order to realistically estimate the magnitude of the problem.

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Audiological and vestibular function tests in hypothyroidism

Cited by 50 publications

References 19 publications

Prevalência das alterações metabólicas em pacientes portadores de queixas vestibulares

Prevalência das alterações metabólicas em pacientes portadores de queixas vestibulares

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Iodine deficiency, thyroid function and hearing deficit: a review

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