Audiological Assessment in Organophosphorus Compound Poisoning

Murthy, V. Ashok; Reddy, Y. J. Visweswara

doi:10.1007/s12070-012-0547-0

Cited by 8 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the occurrence of loss in the high frequencies of 8 and 10 kHz bilaterally, but not in 12 kHz, is intriguing, and no similar result was found in the previous literature. This may be explained by the fact that usually DPOAE studies 1 , 39 do not consider 12 kHz frequency, and this might occur due to limitation of the equipment used.…”

Section: Discussionmentioning

confidence: 99%

Effects of subchronic inhalation exposure to an organophosphorus insecticide compound containing dichlorvos on wistar rats’ otoacoustic emissions

Reis

Cunha

Valle

et al. 2022

Brazilian Journal of Otorhinolaryngology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Effects of subchronic inhalation exposure to an organophosphorus insecticide compound containing dichlorvos on wistar rats’ otoacoustic emissions

Reis

Cunha

Valle

et al. 2022

Brazilian Journal of Otorhinolaryngology

View full text Add to dashboard Cite

“…Vestibulopathy has been described in cohorts of US and Canadian diplomats in Havana. Previous studies associated OP exposure with impaired vestibular function and changes in peripheral and central auditory pathways . Audiovestibular assessment of this patient 5 months after presentation was suggestive of both auditory neuropathy and a central lesion involving the brainstem.…”

Section: Discussionmentioning

confidence: 99%

Neurological Impairments in a Patient Returning From Cuba

2020

View full text Add to dashboard Cite

A 69-year-old woman returning from a vacation in Cuba was brought to the emergency department directly from the airport. Her medical history was unremarkable, and she had no allergies. She had been well until 2 hours before the flight home, when at the Havana airport, she developed generalized weakness, increased sweating, severe nausea, and vomiting. In flight, she had lethargy, vomiting, and urinary incontinence. On arrival to the emergency department, she was stuporous and required intubation. Initial laboratory tests showed a hemoglobin level of 10.9 g/dL (reference range, 12.0-15.2 g/dL [to convert to grams per liter, multiply by 10.0]), a creatinine level of 1.31 mg/dL (reference range, 0.51-1.08 [to convert to micromoles per liter, multiply by 88.4]), and a pH of 7.22 with a normal anion gap. Serum electrolyte levels; a white blood cell count; levels of glucose, creatine kinase, lactic acid, and thyrotropin; coagulation studies; and liver function tests had normal results. An electrocardiogram showed sinus bradycardia at 53 bpm and borderline QT interval prolongation (QTc; 465 milliseconds). A urine toxicology screen had negative results for acetaminophen, salicylates, opiates, barbiturates, benzodiazepines, cocaine, and ethanol. Cerebrospinal fluid was clear, with normal levels of glucose, total protein, and white blood cells and negative microbiology and cytology testing results. A malaria smear and antigen test, respiratory viral assay, and cultures of cerebrospinal fluid, blood, and urine had negative results. Computed tomography of the head showed bilateral hyperdensity of the globus pallidi (Figure 1). Within several hours, her level of consciousness improved spontaneously, and she was extubated. Her blood pressure was 99/61 mm Hg; pulse, 80 bpm; temperature, 37.6 °C; and oxygen saturation, 99% on room air. The patient was alert but disoriented. The pupils were 2 mm and reactive. Involuntary facial muscle twitching was noted. Her muscle tone was normal, and she had mild proximal muscle weakness with occasional bilateral upper extremity and lower extremity fasciculations and jerky movements. Deep tendon reflexes were normal, with flexor plantar responses. Her sensations to pain and vibration were normal.

show abstract

“…Such a change is caused by the inhibition of acetylcholinesterase, which in turn leads to an accumulation of acetylcholine in the peripheral and central auditory pathways [1][2][3][4], affecting the action potential of the efferent system from the superior olivary nucleus to the cochlea [3,5,6]. This way, in humans the exposure to pesticides including organophosphate and/or pyrethroid, either alone or in combination with noise, damages the peripheral auditory system [7][8][9][10] and the central auditory functions [3,[11][12][13][14][15][16][17][18][19][20][21][22] as well as vestibular function [8,10,21].…”

Section: Introductionmentioning

confidence: 99%

Effects of Noise Associated with Pesticides in the Hearing and Vestibular Systems of Endemic Disease Combat Agents

Lacerda¹,

Alcarás²,

Corazza³

et al. 2022

Pesticides - Updates on Toxicity, Efficacy and Risk Assessment

View full text Add to dashboard Cite

The current study aimed to assess the effect of the concomitant exposure to noise and pesticides on the auditory and vestibular systems of endemic disease combat agents. The sample comprised 58 participants, males, divided into two groups. The exposed group (EG) comprised 40 agents, adults, exposed to the noise and pesticides. The control group (CG) comprised 18 participants, without exposure, paired according to age range and gender. The participants from both groups underwent conventional pure-tone audiometry and high-frequency audiometry, evoked otoacoustic emissions and suppression of the emissions, immittance testing, brainstem evoked response audiometry, and dichotic digits test. The vestibular assessment was only carried out in the experimental group. Results showed no difference between the groups in the findings of the pure-tone audiometry and suppression effect of the evoked otoacoustic emissions. Difference was evidenced between the groups in the acoustic reflex testing, the tympanometry, the brainstem evoked response audiometry, and the dichotic digits test, with worse results among the EG. In the vestibular assessment, there was the prevalence of altered tests among EG in 36.4% of the cases, more evidence for the peripheral vestibular dysfunction. In conclusion, noise and pesticide exposure impaired the auditory and vestibular systems of endemic disease control agents.

show abstract

Audiological Assessment in Organophosphorus Compound Poisoning

Cited by 8 publications

References 18 publications

Effects of subchronic inhalation exposure to an organophosphorus insecticide compound containing dichlorvos on wistar rats’ otoacoustic emissions

Effects of subchronic inhalation exposure to an organophosphorus insecticide compound containing dichlorvos on wistar rats’ otoacoustic emissions

Neurological Impairments in a Patient Returning From Cuba

Effects of Noise Associated with Pesticides in the Hearing and Vestibular Systems of Endemic Disease Combat Agents

Contact Info

Product

Resources

About