Audiological profile of asymptomatic Covid-19 PCR-positive cases

Mustafa, Mohamed Wael Mohamed

doi:10.1016/j.amjoto.2020.102483

Cited by 243 publications

(301 citation statements)

References 7 publications

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“…The results of a recent study on the effect of COVID-19 on hearing functions supports our hypothesis (Mustafa, 2020). The author reported that both transient evoked otoacoustic emissions and high frequency pure-tone thresholds amplitudes were significantly worse in the asymptomatic COVID-19 PCR-positive patients group.…”

Section: Mahmut Tayyar Kalcioglusupporting

confidence: 80%

Can COVID-19 cause sudden sensorineural hearing loss?

Kalcıoğlu¹,

Çağ²,

Kılıç³

et al. 2020

International Journal of Infectious Diseases

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Section: Mahmut Tayyar Kalcioglusupporting

confidence: 80%

Can COVID-19 cause sudden sensorineural hearing loss?

Kalcıoğlu¹,

Çağ²,

Kılıç³

et al. 2020

International Journal of Infectious Diseases

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“…In the study performed by Jerome R. Lechien et al 2 ear pain was documented in 61 patients. In the study performed by Mustafa et al 7 , they observed that the high frequency pure-tone thresholds as well as the TEOAE amplitudes were signi cantly worse in the test group. The results of their study showed that COVID-19 infection had deleterious effects on the hair cell of cochlea.…”

Section: Discussionmentioning

confidence: 92%

Otorhinolaryngological manifestations of COVID-19-A systematic review

Govindarajalu¹,

Shah²,

Parsana³

2020

Preprint

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Background: In early December 2019, an outbreak of COVID-19, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan City, Hubei Province, China causing havoc all over the world. As clinicians, recognition of this disease is necessary to isolate these patients to prevent further human to human transmission. Due to its affinity to the respiratory tract and increased viral load in the nose and throat, we as practising otorhinolaryngologists are at increased risk of exposure to this life-threatening virus and warrants an in-depth knowledge on the symptomatology of this disease. This systematic review is intended to highlight the otorhinolaryngological manifestations of COVID-19.Methodology: The literature search was performed on PubMed database using Boolean operators ‘and ‘, ‘or’ as “otorhinolaryngological manifestations” or “rhinology” or “otology” or “larynx” or “hearing” or “olfaction” and “covid19” or “novel corona virus” or “SARS-CoV” with filters as ‘2020’ year of study on 7/08/2020 at 11.30 Am.Review Results: Total of 357 articles were obtained on search and the final 12 articles extracted based on our selection criteria were reviewed. The studies included 6825 laboratory confirmed COVID -19 patients with varying severity of disease. Olfactory dysfunction and taste dysfunction were noted in 2355 and 2224 patients respectively. Nasal obstruction was reported in 323 patients and sore throat in 261 patients. Rhinorrhoea was reported in 209 patients .158 patients complained of post nasal drip and 152 patients presented with facial pain.Conclusion: As a practising otorhinolaryngologist, a good insight into the otorhinolaryngological manifestations of COVID-19 is essential to differentiate between the prodromal symptoms of COVID-19 and non-COVID viral upper respiratory tract infection.

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“…On the pure-tone audiometry, there was a significant difference between the groups at the frequencies of 4,000, 6,000, and 8,000 Hz (p < 0.05), and the transient evoked otoacoustic emissions exhibited a highly significant difference between both groups. 17 Due to the significant global health threat of COVID-19, there is an urgent need for effective treatment that can not only reduce patient's symptoms, but also decrease the duration of virus carriage to limit the transmission in the community. 18 Perhaps, the treatment is the point that leads to more anxiety and doubts, since much has been speculated about it, but there is still controversial data about the safety and efficacy of some drugs, and it is not possible yet to define a therapeutic management that is known to be effective.…”

Section: Discussionmentioning

confidence: 99%

Chloroquine and COVID-19: Should We Care about Ototoxicity?

Monteiro

Nascimento

Brito

et al. 2020

Int Arch Otorhinolaryngol

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Introduction Severe acute respiratory syndrome coronavirus 2 was first described in December 2019 in China leading to a Public Health Emergency of International Concern. It was named by the World Health Organization as Coronavirus Disease 2019 (COVID-19), and it garnered unprecedented attention from public health researchers around the world, and studies analyzing chloroquine and hydroxychloroquine as a possible therapy have arisen in the last 2 months. Objective To review the literature and describe updated facts about the ototoxicity of chloroquine and hydroxychloroquine, an important side effect that can be present in patients with COVID-19 treated with these drugs. Data Synthesis The most typical treatment regimen is 5 days of hydroxychloroquine at daily doses of 400 to 600 mg. There is no randomized clinical trial that can prove so far the efficacy of this medication, and few studies have evaluated adverse events potentially linked to their use in patients with COVID-19. While there is no concrete evidence on the incidence of ototoxicity using chloroquine in the short term, we need to consider that, as a pandemic disease, millions of patients with COVID-19 may receive this treatment, and ototoxicity can be a possible adverse event. Conclusion Despite the urgent global situation caused by the COVID-19, the risk of irreversible hearing loss may outweigh the unproven benefit of using hydroxychloroquine or chloroquine, especially in patients with mild forms of COVID-19, who may be cured with supportive treatment. The potential hearing loss that can be caused by these medications may advise against their use in COVID-19 patients.

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Audiological profile of asymptomatic Covid-19 PCR-positive cases

Cited by 243 publications

References 7 publications

Can COVID-19 cause sudden sensorineural hearing loss?

Can COVID-19 cause sudden sensorineural hearing loss?

Otorhinolaryngological manifestations of COVID-19-A systematic review

Chloroquine and COVID-19: Should We Care about Ototoxicity?

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