Auditory brain stem responses in chronic alcoholic patients

Chu, Nai‐Shin; Squires, Kenneth C.; Starr, Arnold

doi:10.1016/0013-4694(82)90205-x

Cited by 49 publications

(9 citation statements)

References 19 publications

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“…As in other studies, visual and auditory evoked potentials were also altered in alcoholics [7,[44][45][46]. In our series, asymptomatic, well-nourished, chronic alcoholics showed a significant prolongation of the latency PI00 at the angle of 17 degrees, a prolongation of V latency, and a reduction in the amplitudes of the evoked auditory waves.…”

Section: Discussionsupporting

confidence: 87%

Brain impairment in well‐nourished chronic alcoholics is related to ethanol intake

Nicolás

Estruch

Salamero

et al. 1997

Annals of Neurology

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To determine the influence of chronic ethanol intake on the central nervous system, we studied 40 asymptomatic, well-nourished, chronic alcoholics (mean age, 42.6 +/- 9.1 years) and 20 age-, sex-, and education-matched control subjects. Studies included neuropsychological testing, visual and short-latency auditory evoked potentials, and morphometric analysis of computed tomography scans. The mean daily ethanol consumption of the alcoholics was 204 gm over an average of 26.4 years. Compared to control subjects, chronic alcoholics exhibited a significant prolongation of the P100 latency of visual evoked potentials, and a prolongation and reduction in the amplitude of the latency of the V wave of short-latency auditory evoked potentials. These abnormalities were related to the lifetime dose of ethanol consumed. Brain morphometric analysis showed that alcoholics had a significantly greater degree of brain shrinkage with age, compared to control subjects. The cortical atrophy index correlated significantly with the lifetime ethanol consumption. Neuropsychological testing in alcoholics compared to controls revealed a significant impairment of frontal skills that was related to age, degree of scholarship, and the presence of frontal atrophy. In conclusion, well-nourished chronic alcoholics exhibited significant brain impairment, as demonstrated by neuropsychological testing, evoked potentials, and brain morphometric analysis, which was correlated with the lifetime dose of ethanol consumed.

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Section: Discussionsupporting

confidence: 87%

Brain impairment in well‐nourished chronic alcoholics is related to ethanol intake

Nicolás

Estruch

Salamero

et al. 1997

Annals of Neurology

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“…Because biochemical and neuropathological studies have indicated that there are certain differences between the HE associated with liver cirrhosis and portal systemic shunting and the HE associated with acute hepatitis (23)(24)(25)(26), the electrophysiological responses such as BAEPs may differ in those two types of HE. Another difference was that one-fourth of the patients studied by Martines et al (22) were chronic alcoholics and abnormal BAEPs are not uncommon in the latter (27)(28)(29). Therefore, the present study and that of Martines et al (22) seem to suggest that abnormalities of BAEPs in HE may depend upon the underlying causes of HE.…”

Section: Discussioncontrasting

confidence: 63%

Brainstem auditory evoked potentials in hepatic encephalopathy

1986

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Brainstem auditory evoked potentials were obtained from 30 patients primarily with viral hepatitis to determine the functional status of the brainstem in hepatic encephalopathy. The patients were divided into four groups: Group 1 with compensated hepatic diseases; Group 2 with hepatic failure but no hepatic encephalopathy; Group 3 with Grade 1 or 2 hepatic encephalopathy, and Group 4 with Grade 3 or 4 hepatic encephalopathy. The brainstem auditory evoked potential central conduction times (I-V interval) of four patient groups were not significantly different from that of the age-matched control group. The present data suggest that the brainstem auditory pathways remain undisturbed in hepatic encephalopathy.

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“…We can also deduce from our data that the protess underlying alcoholic neuropathy is not only segmental demyelination, as Denny-Brown [18] asserted, or axonal degeneration, as stated by others [4,54,66,76], but the two together, probably starting with a demyelinating mechanism, axonal degeneration intervening later and rendering the damage permanent. Ethyl alcohol not only affects the PNS but also slows central nervous conduction in the brain both in animals and in man, whether after acute [62,63] or after chronic administration [5,15,16,60]. This is substantiated by the large increase in distal motor latency, which is present both in the ever-alcoholics and in the abstainers.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of peripheral nerve conduction and central visual conduction in chronic alcoholics and in chronic alcoholics after prolonged abstention

Devetag

1988

Ital J Neuro Sci

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Classic statistical method (mean, standard deviation, variance) were used to analyze peripheral nerve conduction tests and visual evoked potentials in 13 chronic alcoholics and in 11 chronic alcoholics who had abstained for at least one year, in order to assess the repercussions of alcohol on the PNS and on the visual pathways and their reversibility. The sensory fibers were more affected than the motor fibers, and while the damage to the motor fibers was transient the damage to the sensory fibers was permanent and also significantly different, at least in the early stages, in the two lower limbs. Our results showed constant involvement, without clinical symptoms, of the visual potential, especially of the earliest component N70 and of the amplitude of the response. This would suggest greater involvement of the peripheral visual nervous structures, that is retino-geniculo-cortical, than of the more properly cortical structures, though these are also affected. For the visual damage too withdrawal of alcohol seems to determine a regression, though only partial, of the neurophysiological changes. The simultaneous involvement of VEP and peripheral nerve function is at variance with the assertion that optic nerve damage is a very rare event in alcoholism.

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Auditory brain stem responses in chronic alcoholic patients

Cited by 49 publications

References 19 publications

Brain impairment in well‐nourished chronic alcoholics is related to ethanol intake

Brain impairment in well‐nourished chronic alcoholics is related to ethanol intake

Brainstem auditory evoked potentials in hepatic encephalopathy

Evaluation of peripheral nerve conduction and central visual conduction in chronic alcoholics and in chronic alcoholics after prolonged abstention

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