Auditory Brainstem Evoked Response in Juvenile Rats Fed Rat Milk Formulas with High Docosahexaenoic Acid

Auestad, Nancy; Stockard-Sullivan, Janet; Innis, Sheila M.; Korsak, Rose A.; Edmond, John

doi:10.1080/10284150310001624183

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…Maturation and increasing specificity of auditory sensory systems, fundamental to developmental sensitivities of grammatical and semantic/lexical (object-word association) language learning, involve a gradual decrease in responses of occipital regions to auditory stimuli from 6 to 36 mo of age. Although apparently not studied in humans, experimental work has reported evidence of altered auditory evoked potentials in offspring of animals given DHA during pregnancy [56]. We found no evidence of fetal DHA insufficiency sufficient to constrain cognitive, gross motor or fine motor development when assessed using the BSID-III at 18 mo of age.…”

Section: Discussioncontrasting

confidence: 59%

Omega-3 Fatty Acid Deficiency in Infants before Birth Identified Using a Randomized Trial of Maternal DHA Supplementation in Pregnancy

2014

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BackgroundDHA is accumulated in the central nervous system (CNS) before birth and is involved in early developmental processes, such as neurite outgrowth and gene expression.ObjectiveTo determine whether fetal DHA insufficiency occurs and constrains CNS development in term gestation infants.DesignA risk reduction model using a randomized prospective study of term gestation single birth healthy infants born to women (n = 270) given a placebo or 400 mg/day DHA from 16 wk gestation to delivery. Fetal DHA deficiency sufficient to constrain CNS development was assessed based on increased risk that infants in the placebo group would not achieve neurodevelopment scores in the top quartile of all infants in the study.ResultsInfants in the placebo group were at increased risk of lower language development assessed as words understood (OR 3.22, CL 1.49–6.94, P = 0.002) and produced (OR 2.61, CL 1.22–5.58, P = 0.01) at 14 mo, and words understood (OR 2.77, CL 1.23–6.28, P = 0.03) and sentences produced (OR 2.60, CL 1.15–5.89, P = 0.02) at 18 mo using the McArthur Communicative Developmental Inventory; receptive (OR 2.23, CL 1.08–4.60, P = 0.02) and expressive language (OR 1.89, CL 0.94–3.83, P = 0.05) at 18 mo using the Bayley Scales of Infant Development III; and visual acuity (OR 2.69, CL 1.10–6.54, P = 0.03) at 2 mo.Trial RegistrationClinicalTrials.gov NCT00620672

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Section: Discussioncontrasting

confidence: 59%

Omega-3 Fatty Acid Deficiency in Infants before Birth Identified Using a Randomized Trial of Maternal DHA Supplementation in Pregnancy

2014

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“…The differences in the distribution at P10 and P14 in OSB indicated that the mature synaptic connections were established between OHCs and nerve terminals; this phase was also consistent with the onset of hearing. 2 The distribution differences between groups showed that the OHCs were controlled by the SGNs, which released neurotransmitters, but the concrete mechanism requires further investigation. Similarly, changes in hair cell function during neurite retraction and synapse pruning may also contribute to variation in synaptic stability.…”

Section: Discussionmentioning

confidence: 99%

“…The development of the rat auditory system lasts from the embryonic period to 14 days after birth. 1,2 . The maturation of the auditory system has been shown to be affected by the external environment, hormones and other factors after birth.…”

Section: Introductionmentioning

confidence: 99%

Maturation of neurotransmission in the developing rat cochlea: immunohistochemical evidence from differential expression of synaptophysin and synaptobrevin 2

He¹,

Yang

2011

Eur J Histochem

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Synaptophysin and synaptobrevin 2 associate closely with packaging and storage of synaptic vesicles and transmitter release, and both play important roles in the development of rat cochlea. We examined the differential expression of synaptophysin and synaptobrevin 2 in the developing Sprague-Dawley rat cochlea, and investigated the relationship between their expression and auditory development. The expression of synaptophysin and synaptobrevin 2 was not observed in Kolliker's and Corti's organ at postnatal 1 day (P1) and P5, and the top turn of the cochlea at P10. Expression was detected in the outer spiral bundle (OSB), the inner spiral bundle (ISB), and the medial wall of the Deiters' cell of the cochlea at P14, and P28, and in the middle or the basal turn of Corti's organ at P10. Synaptobrevin 2 was expressed in the top of the inner hair cells (IHCs) in Corti's organ of both P14 and P28 rats. All spiral ganglion neurons (SGNs) were stained at all ages examined. The localization of synaptophysin and synaptobrevin 2 in the cochlea was closely associated with the distribution of nerve fibers and neural activity (the docking and release of synaptic vesicles). Synaptophysin and synaptobrevin 2 were expressed in a dynamic manner during the development of rat cochlea. Their expression differences during the development were in favor of the configuration course constructed between nerve endings and target cells. It also played a key role in the formation of the correct coding of auditory information during auditory system development.

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“…Postnatal formula supplementation with DHA + AA resulted in longer latencies compared to supplementation with DHA alone or to the control group (Auestad et al, 2003). However the application of experimental animal studies to human nutrition ones is limited by differences in auditory development and doses provided.…”

Section: Resultsmentioning

confidence: 96%

Neurophysiologic measures of auditory function in fish consumers: Associations with long chain polyunsaturated fatty acids and methylmercury

Dziorny¹,

Orlando²,

Strain³

et al. 2013

NeuroToxicology

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Background Determining if associations exist between child neurodevelopment and environmental exposures, especially low level or background ones, is challenging and dependent upon being able to measure specific and sensitive endpoints. Psychometric or behavioral measures of CNS function have traditionally been used in such studies, but do have some limitations. Auditory neurophysiologic measures examine different nervous system structures and mechanisms, have fewer limitations, can more easily by quantified, and might be helpful testing additions. To date, their use in human epidemiological studies has been limited. We reviewed the use of auditory brainstem responses (ABR) and otoacoustic emissions (OAE) in studies designed to determine the relationship of exposures to methyl mercury (MeHg) and nutrients from fish consumption with neurological development. We included studies of experimental animals and humans in an effort to better understand the possible benefits and risks of fish consumption. Objectives We reviewed the literature on the use of ABR and OAE to measure associations with environmental exposures that result from consuming a diet high in fish. We focused specifically on long chain polyunsaturated fatty acids (LCPUFA) and MeHg. Methods We performed a comprehensive review of relevant studies using web-based search tools and appropriate search terms. Results Gestational exposure to both LCPUFA and MeHg has been reported to influence the developing auditory system. In experimental studies supplemental LCPUFA is reported to prolong ABR latencies and human studies also suggest an association. Experimental studies of acute and gestational MeHg exposure are reported to prolong ABR latencies and impair hair cell function. In humans, MeHg exposure is reported to prolong ABR latencies, but the impact on hair cell function is unknown. Conclusion The auditory system can provide objective measures and may be useful in studying exposures to nutrients and toxicants and whether they are associated with children’s neurodevelopment.

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Auditory Brainstem Evoked Response in Juvenile Rats Fed Rat Milk Formulas with High Docosahexaenoic Acid

Cited by 12 publications

References 28 publications

Omega-3 Fatty Acid Deficiency in Infants before Birth Identified Using a Randomized Trial of Maternal DHA Supplementation in Pregnancy

Omega-3 Fatty Acid Deficiency in Infants before Birth Identified Using a Randomized Trial of Maternal DHA Supplementation in Pregnancy

Maturation of neurotransmission in the developing rat cochlea: immunohistochemical evidence from differential expression of synaptophysin and synaptobrevin 2

Neurophysiologic measures of auditory function in fish consumers: Associations with long chain polyunsaturated fatty acids and methylmercury

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