Auditory brainstem responses after ovariectomy and estrogen replacement in rat

Coleman, James R.; Campbell, D.; Cooper, William A.; Welsh, Marcia G.; Moyer, John A.

doi:10.1016/0378-5955(94)90112-0

Cited by 104 publications

(83 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…removal of the endogenous estrogen production), leads to changes in ABR with prolonged latencies. These changes are reversed by estrogen replacement (Coleman et al 1994). ER-b is found to be expressed at high levels in the central nervous system, both in neurons and glial cells (Wang et al 2001).…”

Section: Discussionmentioning

confidence: 89%

Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

Simonoska¹,

Stenberg²,

Duan

et al. 2009

Journal of Endocrinology

View full text Add to dashboard Cite

There are well known differences between males and females in hearing. In the present study, the role of estrogen receptor-b (ER-b; listed as ESR2 in the MGI Database) in hearing was investigated by comparing hearing and morphology of the inner ear in ER-b knock-out mice (ER-b) with that of wild-type (WT) littermates. Hearing was analyzed with auditory brainstem response audiometry at 3 and 12 months. The ER-b K/K mice were deaf at 1 year of age, and the morphological analysis showed absence of hair cells and loss of the whole organ of Corti initiated in the basal turn of the cochlea. Furthermore, in ER-b, but not in WT mice, the spiral ganglion was lacking many of its neurons.Immunostaining showed the presence of both ER-a (listed as ESR1 in the MGI Database) and ER-b in the nuclei of some neurons in the inner ear in WT mice, but no ER-b was found in the ER-b K/K mice as expected. ER-a staining was predominant in the nuclei of large neurons and ER-b in nuclei of small neurons and fibroblasts. These results reveal that both ERs are present in the inner ear at specific localizations suggesting subtype-specific functions. It is concluded that ER-b is important for the prevention of agerelated hearing loss. These findings strengthen the hypothesis that estrogen has a direct effect on hearing functions.

show abstract

Section: Discussionmentioning

confidence: 89%

Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

Simonoska¹,

Stenberg²,

Duan

et al. 2009

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Estrogen is known to affect neural systems in a variety of ways that can be neuroprotective/positive or (less commonly) neurotoxic/negative (e.g., Belisle et al, 1985;Bergman et al, 1989;Bittar et al, 2001;Easton et al, 2006;GarciaSegura et al, 2001;Papalexi et al, 2005;Picazo et al, 2003;Toran-Allerand et al, 1999;Usui, 2006), leaving open many possibilities to be addressed by future research. Various lines of evidence suggest that ovarian hormones may affect auditory function directly (Coleman et al, 1994;Hultcrantz et al, 2006). Estrogen receptors have been observed in the mouse cochlea (Stenberg et al, 1999; but see Nathan et al, 1999), although there is no indication as to what role they might play.…”

Section: Sex Differences In Control (Non-exposed) Mice and The Effectmentioning

confidence: 99%

Effects of exposing gonadectomized and intact C57BL/6J mice to a high-frequency augmented acoustic environment: Auditory brainstem response thresholds and cytocochleograms

et al. 2006

View full text Add to dashboard Cite

Gonadectomized and surgically intact adult C57BL/6J (B6) mice of both sexes were exposed for 12 hours nightly to a high-frequency augmented acoustic environment (AAE): repetitive bursts of a half-octave noise band centered at 20 kHz, 70 dB SPL. The effects of sex, gonadectomy, and AAE treatment on genetic progressive hearing loss (exhibited by B6 mice) were evaluated by obtaining auditory brainstem response thresholds at ages 3-, 6-, and 9-months; hair cell counts (cytocochleograms) were obtained at 9 months. A sex difference in the rate of genetic progressive hearing loss in B6 mice (observed by earlier studies) was confirmed, with females exhibiting a faster rate of threshold elevations and more severe loss of hair cells at age 9 months. Gonadectomy had no consistent effects on the rate or severity of hearing loss in nonexposed mice of either sex. An unexpected finding was that the high-frequency AAE treatment caused additional ABR threshold elevations and hair cell loss. In an earlier study, the same high-frequency AAE treatment on DBA/ 2J mice ameliorated hearing loss. The most severe AAE-induced losses occurred in surgically intact females, suggesting a potentiating effect of ovarian hormone(s).

show abstract

“…This characteristic is common in many rodents exhibiting audiogenic seizures [83,84]. These animals tend to show a reduction in their ABR response latencies, even to stimulations at 8 kHz, which is the optimal frequency for hearing in rats and most rodents [85]. Mice prone to audiogenic seizures have shown increased excitability upon hearing, which is characterized by higher amplitude of the ABR in the cochlear nucleus and inferior colliculus at intensities above the hearing threshold [17].…”

Section: Abrmentioning

confidence: 99%

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Muñoz

Carballosa-Gautam

Yanowsky

et al. 2017

Epilepsy & Behavior

View full text Add to dashboard Cite

The hamster has been previously described as a paroxysmal dystonia model, but our strain is currently recognized as a model of audiogenic seizures (AGS). The original first epileptic hamster appeared spontaneously at the University of Valladolid, where it was known as the GPG:Vall line, and was transferred to the University of Salamanca where a new strain was developed, named GASH:Sal. By testing auditory brainstem responses, the GASH:Sal exhibits elevated auditory thresholds that indicate a hearing impairment. Moreover, amplified fragment length polymorphism analysis distinguished genetic differences between the susceptible GASH:Sal hamster strain and the control Syrian hamsters. The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic-clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem. The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.This article is part of a Special Issue entitled Genetic Models-Epilepsy.

show abstract

Auditory brainstem responses after ovariectomy and estrogen replacement in rat

Cited by 104 publications

References 22 publications

Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

Effects of exposing gonadectomized and intact C57BL/6J mice to a high-frequency augmented acoustic environment: Auditory brainstem response thresholds and cytocochleograms

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Contact Info

Product

Resources

About