Auditory Closed-Loop Stimulation of the Sleep Slow Oscillation Enhances Memory

Ngo, Hong Viet; Martinetz, Thomas; Born, Jan; Mölle, Matthias

doi:10.1016/j.neuron.2013.03.006

Cited by 771 publications

(1,043 citation statements)

References 38 publications

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“…Other than improving and developing new pharmacotherapeutic treatments, researchers have now begun seeking alternatives to drug treatments by strengthening memory consolidation during sleep. For example, enhancing spindle activity and slow wave oscillations via external stimulation administered in synchrony with the endogenous rhythm of the brain during sleep can strengthen memory consolidation in humans and rodents (Marshall et al 2006;Massimini et al 2007;Vyazovskiy et al 2009;Ngo et al 2013). Hopefully, by identifying molecular targets and circuitry disrupted by sleep deprivation, we can develop more effective treatments for the accompanying impairments in cognition.…”

Section: Resultsmentioning

confidence: 99%

The impact of sleep loss on hippocampal function

2013

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Hippocampal cellular and molecular processes critical for memory consolidation are affected by the amount and quality of sleep attained. Questions remain with regard to how sleep enhances memory, what parameters of sleep after learning are optimal for memory consolidation, and what underlying hippocampal molecular players are targeted by sleep deprivation to impair memory consolidation and plasticity. In this review, we address these topics with a focus on the detrimental effects of post-learning sleep deprivation on memory consolidation. Obtaining adequate sleep is challenging in a society that values "work around the clock." Therefore, the development of interventions to combat the negative cognitive effects of sleep deprivation is key. However, there are a limited number of therapeutics that are able to enhance cognition in the face of insufficient sleep. The identification of molecular pathways implicated in the deleterious effects of sleep deprivation on memory could potentially yield new targets for the development of more effective drugs.

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Section: Resultsmentioning

confidence: 99%

The impact of sleep loss on hippocampal function

2013

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“…In healthy individuals, increasing spindles with zolpidem 66,67 , increasing sigma activity with transcranial stimulation 68,69 and enhancing the synchronization of sigma activity with slow oscillations using auditory closed-loop stimulation 70 all improve memory, while transcranial stimulation that decreases sigma activity impairs memory 71 . Only a few studies have attempted to improve cognition in schizophrenia by manipulating sleep oscillations.…”

Section: Discussionmentioning

confidence: 99%

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Demanuele

Bartsch

Baran

et al. 2016

Sleep

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Demanuele et al., 2016 1 This study is not a clinical trial. Demanuele et al., 2016 3 Coordination of Slow Waves with Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia AbstractStudy Objectives: Schizophrenia patients have correlated deficits in sleep spindle density and sleep-dependent memory consolidation. In addition to spindle density, memory consolidation is thought to rely on the precise temporal coordination of spindles with slow waves (SWs). We investigated whether this coordination is intact in schizophrenia and its relation to motor procedural memory consolidation.Methods: Twenty-one chronic medicated schizophrenia patients and 17 demographicallymatched healthy controls underwent two nights of polysomnography with training on the finger tapping motor sequence task (MST) on the second night and testing the following morning. We detected SWs (0.5-4Hz) and spindles during non-rapid eye-movement (NREM) sleep. We measured SW-spindle phase-amplitude coupling and its relation with overnight improvement of MST performance.Results: Patients did not differ from controls in the timing of SW-spindle coupling. In both groups spindles peaked during the SW upstate. For patients only, the later in the SW upstate that spindles peaked and the more reliable this phase relationship, the greater the overnight MST improvement.Regression models that included both spindle density and SW-spindle coordination predicted overnight improvement significantly better than either parameter alone suggesting that both contribute to memory consolidation.Conclusions: Schizophrenia patients show intact spindle-SW temporal coordination and these timing relationships, together with spindle density, predict sleep-dependent memory consolidation.These relations were seen only in patients suggesting that their memory is more dependent on optimal spindle-SW timing, possibly due to reduced spindle density. Interventions to improve memory may need to both increase spindle density and optimize the coordination of NREM oscillations.

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“…Born's lab has already used low-level electrical stimulation to boost people's memory. Just last month they showed that synchronized sounds can enhance slow waves during sleep and increase memory for word pairs 9 . In the meantime, there is no denying the importance of a good night's sleep.…”

Section: A Day To Remembermentioning

confidence: 99%

Neuroscience: Off to night school

Smith

2013

Nature

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Auditory Closed-Loop Stimulation of the Sleep Slow Oscillation Enhances Memory

Cited by 771 publications

References 38 publications

The impact of sleep loss on hippocampal function

The impact of sleep loss on hippocampal function

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Neuroscience: Off to night school

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