Auditory Event-Related Potentials in Parkinson's Disease in Relation to Cognitive Ability

Katsarou, Zoe; Bostantjopoulou, Sevasti; Kimiskidis, Vasilios K.; Rossopoulos, E.; Kazis, A.

doi:10.2466/pms.98.3c.1441-1448

Cited by 36 publications

(18 citation statements)

References 19 publications

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“…Tsuchiya et al (2000) for example have found prolonged latency of P3a, but not of P3b in PD patients, concluding that the orienting response in PD patients was impaired. Prolongation of P3b latency has been found in other studies as well (Katsarou, Bostantjopoulou, Kimiskidis, Rossopoulos, & Kazis, 2004;Raudino, Garavaglia, Beretta, & Pellegrini, 1997;Tachibana, Aragane, Miyata, & Sugita, 1997). In a review of ERPs in different neurological conditions, Verleger (2003) concluded that the P3 latency tends to be prolonged in PD patients, particularly in those with overt cognitive decline.…”

Section: No Differences In P3a/b Latency Between Groups or Due To Dopmentioning

confidence: 77%

Dopaminergic medication alters auditory distractor processing in Parkinson's disease

et al. 2015

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Section: No Differences In P3a/b Latency Between Groups or Due To Dopmentioning

confidence: 77%

Dopaminergic medication alters auditory distractor processing in Parkinson's disease

et al. 2015

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“…In this task, a series of binaural tones at 70-dB sound pressure level (SPL) with a 10 ms rise/fall and a 100ms, plateau time was presented to all subjects. The auditory stimuli were presented in a random sequence with target tones of 2000Hz occurring 20% of the time and standard tones of 1000Hz occurring 80% of the time at a rate of 0.5Hz [25]. The subject was required to distinguish between the two tones by responding to the target (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…The peak of the ERP components was determined as follows: if the waveform was smooth, the maximal amplitude point was taken as the peak. Otherwise, the leading and trailing slopes of the waveform were extended, and the intersection point was determined [25]. For the purpose of reduced impedance we used a special type of paste (Elefix Nihon-Kohden, EEG paste Z-401 CE), while the AERPs were analyzed by means of Neuropack 4 (NihonKohden, Tokyo) equipment.…”

Section: Methodsmentioning

confidence: 99%

Prediction of Conversion from Mild Cognitive Impairment to Alzheimer ’ s Disease by CSF Cytochrome c Levels and N200 Latency

Papaliagkas

Anogianakis²,

Tsolaki

et al. 2009

CAR

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The aim of the present study was to investigate the role of CSF cytochrome c levels and auditory event-related potentials (AERPs) on the progress of mild cognitive impairment (MCI) to Alzheimer's disease (AD). Fifty one patients diagnosed with MCI and fourteen healthy individuals underwent lumbar puncture at baseline and their CSF cytochrome c levels were determined. A follow-up examination of cytochrome c levels took place in 20 patients after 11 months and in this period five of the patients progressed to AD. ERP examinations were also performed in all patients both at baseline and follow-up. MCI patients had significantly higher cytochrome c levels compared to healthy controls (Mann-Whitney test, Z=-2.110, p=0.018). Compared to MCI patients who remained stable, the AD-converters, had a higher increase over time in cytochrome c levels (Mann-Whitney test, p=0.002; effect size r=0.63) and significantly prolonged N200 latency (Mann-Whitney test, p<0.001; effect size r=0.50). Amongst investigated ERP variables, only N200 amplitude was significantly correlated with CSF cytochrome c levels (rs=0.310, p=0.03). Both parameters were proved capable of discriminating AD converters from those MCI patients who remained stable, with sensitivity and specificity >75%. Our results suggest that conversion from MCI to AD is associated with a marked elevated N200 latency at baseline and a high increase in cytochrome c levels during a relatively short period of time, and that both parameters could be possibly considered as candidate markers for the discrimination between MCI patients who convert to AD and those who remain stable.

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“…In neurodegenerative diseases accompanied by dementia, weakening of memory, and disturbances of attention, the latency of the Р300 potential is greater than in the norm. This is why the parameters of this wave are extensively used in clinical studies as neurophysiological correlates of the state of cognitive functions [6,7].…”

Section: Introductionmentioning

confidence: 99%

Correlations between indices of P300 EEG potential, cognitive tests, and variational pulsometry in Parkinsonian patients

Lukhanina

Melnyk²,

Berezetskaya³

et al. 2008

Neurophysiology

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The parameters of an event-related EEG potential (ERP), Р300 wave, are now extensively used as objective neurophysiological indices of the state of cognitive functions. At the same time, information on the effects of the autonomic nervous system on the parameters of Р300 is limited. In Parkinson's disease clinics, in addition to the leading motor disorders, more or less clear psychoemotional, cognitive, and autonomic (in particular cardiovascular) impairments are usually observed. This allows one to study the dependence between the cardiovascular dysfunction and intensity of cognitive disorders in Parkinsonian patients. In our study on this contingent, we analyzed correlations between the parameters of P300 potential, indices of the state of the cognitive sphere (determined using a questionnaire, Mini Mental State Examination, MMSE, and a Luriya's test), and indices of variational pulsometry. Thirty-five Parkinsonian patients (49 to 74 years, severity of disease 1.5 to 3.0 by the international classification) were examined. We found a negative influence of excessive sympathetic tonus in cardiovascular control on the state of cognitive functions. The latency of Р300 potential was longer in patients with greater intensities of sympathetic influences on the cardiovascular system. The coefficients of correlation of the latency of Р300 with the amplitude of mode of R-R intervals (AMo), index of tension in the regulatory systems by Baevskii (IT), and index of autonomic balance by Baevskii (IAB) were 0.52 (P < 0.01), 0.36 (P < 0.05), and 0.37 (P < 0.05), respectively. The above autonomic indices demonstrated significant negative correlations with the volume of short-term memory measured by Luriya's test. The Р300 latency, in turn, showed negative correlations with the memory volume estimated by the MMSE scale and Luriya's test. With increase in the age of patients, the degree of the above-mentioned correlations between the Р300 latency, memory volume (by Luriya's test), and parameters of variational pulsometry increased. Our data emphasize the expedience of "routine" studies of the balance of sympathetic and parasympathetic control in pathological states accompanied by clear or subclinical cognitive disorders. Early recognition of cardiovascular dysfunction and its corresponding therapeutic correction should improve the state of brain functions and quality of life in patients suffering from neurodegenerative diseases, in particular from Parkinson's disease.

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Auditory Event-Related Potentials in Parkinson's Disease in Relation to Cognitive Ability

Cited by 36 publications

References 19 publications

Dopaminergic medication alters auditory distractor processing in Parkinson's disease

Dopaminergic medication alters auditory distractor processing in Parkinson's disease

Prediction of Conversion from Mild Cognitive Impairment to Alzheimer ’ s Disease by CSF Cytochrome c Levels and N200 Latency

Correlations between indices of P300 EEG potential, cognitive tests, and variational pulsometry in Parkinsonian patients

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