Dopaminergic medication alters auditory distractor processing in Parkinson's disease

Georgiev, Dejan; Jahanshahi, Marjan; Dreo, Jurij; Čuš, Anja; Pirtošek, Zvezdan; Repovš, Grega

doi:10.1016/j.actpsy.2015.02.001

Cited by 24 publications

(36 citation statements)

References 79 publications

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“…Some studies indicated the positive role of dopaminergic treatment in the auditory paradigms. Georgiev et al (2015) showed that the effect of medication on P3a response was observed only during auditory stimulations but not during visual stimulations. Geiser and Kaelin-Lang (2011) showed that auditory pulse perception was preserved in PD patients during the early stages of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore it was not possible to control the effects of medication. The effect of L-Dopa on spontaneous EEG, ERPs ( Georgiev et al, 2015 ) and as well as in different frequency bands were reported ( Huebl et al, 2014 ). However, little is known about the effect of medication on event related oscillations in PD patients with different cognitive states, and it remains an essential question.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive Impairment in Parkinson’s Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination

et al. 2018

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Parkinson’s disease (PD) is a neurodegenerative disease that is characterized by loss of dopaminergic neurons in the substantia nigra. Mild Cognitive impairment (MCI) and dementia may come along with the disease. New indicators are necessary for detecting patients that are likely to develop dementia. Electroencephalogram (EEG) Delta responses are one of the essential electrophysiological indicators that could show the cognitive decline. Many research in literature showed an increase of delta responses with the increased cognitive load. Furthermore, delta responses were decreased in MCI and Alzheimer disease in comparison to healthy controls during cognitive paradigms. There was no previous study that analyzed the delta responses in PD patients with cognitive deficits. The present study aims to fulfill this important gap. 32 patients with Parkinson’s disease (12 of them were without any cognitive deficits, 10 of them were PD with MCI, and 10 of them were PD with dementia) and 16 healthy subjects were included in the study. Auditory simple stimuli and Auditory Oddball Paradigms were applied. The maximum amplitudes of each subject’s delta response (0.5–3.5 Hz) in 0–600 ms were measured for each electrode and for each stimulation. There was a significant stimulation × group effect [F(df = 6,88) = 3,21; p < 0.015; ηp2 = 0.180], which showed that the difference between groups was specific to the stimulation. Patients with Parkinson’s disease (including PD without cognitive deficit, PD with MCI, and PD with dementia) had reduced delta responses than healthy controls upon presentation of target stimulation (p < 0.05, for all comparisons). On the other hand, this was not the case for non-target and simple auditory stimulation. Furthermore, delta responses gradually decrease according to the cognitive impairment in patients with PD.Conclusion: The results of the present study showed that cognitive decline in PD could be represented with decreased event related delta responses during cognitive stimulations. Furthermore, the present study once more strengthens the hypothesis that decrease of delta oscillatory responses could be the candidate of a general electrophysiological indicator for cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cognitive Impairment in Parkinson’s Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination

et al. 2018

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“…Georgiev et al, (2015) have shown that auditory processing is altered in PD patients. PD patients, tested with medication manipulation, were compared to healthy agematched controls and have displayed deficits in distractor processing in the auditory modality (Georgiev et al, 2015). Moreover, PD patients tested on medication have shown deficiencies in neural entrainment, with an associated deficit between auditory to motor entrainment (te Woerd et al., 2017a, 2017b, 2015).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Aging, Parkinson’s Disease, and Exogenous Dopamine on the Neural Response Associated with Auditory Regularity Processing

Jaja¹,

Grahn²,

Herrmann³

et al. 2019

Preprint

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Processing regular patterns in auditory scenes is important for navigating complex environments. Electroencephalography (EEG) studies find enhancement of sustained brain activity, correlating with the emergence of a regular pattern in sounds. How aging, aging-related diseases such as Parkinson's disease (PD), and treatment of PD affect this fundamental function remain unknown. We addressed this knowledge gap. Healthy younger and older adults, and PD patients listened to sounds that contained or were devoid of regular patterns. Healthy older adults and PD patients were tested twice-on and off dopaminergic medication in counterbalanced order.Regularity-evoked, sustained EEG activity was reduced in older, compared to younger adults. PD patients and older controls had comparable attenuation of the sustained response. Dopaminergic therapy further weakened the sustained response in both groups. These findings suggest that fundamental regularity processing is impacted by aging-related neural changes but not those underlying PD. The finding that dopaminergic therapy attenuates rather than improves the sustained response coheres with the dopamine overdose response and implicates brain regions receiving dopamine from the ventral tegmental area in regularity processing.

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“…P3a amplitude has been found to be attenuated in PD in some studies (Li et al, 2005;Solís-Vivanco et al, 2011Tsuchiya et al, 2000;Wang et al, 1999Wang et al, , 2000, but not in others (Bocquillon et al, 2012;Gaudreault et al, 2013;Georgiev et al, 2015;Hozumi et al, 2000;Pirtošek et al, 2001;Tachibana et al, 1992;Toda et al, 1993;Zeng et al, 2002 et al, 2000). In addition, smaller P3a amplitudes obtained from threestimulus oddball tasks have been associated with more efficient performance in more demanding tasks (Lange et al, 2015).…”

Section: P3b In Pd: Conclusion and Future Directionsmentioning

confidence: 99%

“…Hence, medication effects were always confounded with potential effects of learning, fatigue or habituation. In a recent study that controlled for these factors (Georgiev et al, 2015), no differences in P3b latency have been found as a function of PD patients' dopaminergic status (see also Vieregge et al, 1994). Second, it has to be noted that sample sizes were considerably smaller in the studies reporting a levodopa-associated decrease in P3b latency (mean N = 14.8) than in the studies reporting no such effect (mean N = 23.5; pone-tailed t-test = 0.03), thus challenging the reliability of the proposed levodopa effect.…”

Section: P3b and Dopaminergic Medication In Pdmentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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Dopaminergic medication alters auditory distractor processing in Parkinson's disease

Cited by 24 publications

References 79 publications

Cognitive Impairment in Parkinson’s Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination

Cognitive Impairment in Parkinson’s Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination

The Effect of Aging, Parkinson’s Disease, and Exogenous Dopamine on the Neural Response Associated with Auditory Regularity Processing

Event-related potentials and cognition in Parkinson’s disease: An integrative review

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