Auditory evoked potentials in aged gerbils: responses elicited by noises separated by a silent gap

Boettcher, Flint A.; Mills, John H.; Swerdloff, Jason; Holley, Brenda L.

doi:10.1016/s0378-5955(96)90016-7

Cited by 76 publications

(73 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rather, deficits in central auditory processing seem to contribute to impaired temporal resolution in these animals. This view is also supported by the ABR data from Boettcher et al (1996). Presenting two short noise pulses that were separated by a variable gap, they showed that the CAP latencies were very similar in young and old gerbils, but latencies to the second noise pulse were slightly higher for wave II and clearly longer for wave IV at shorter gap duration, suggesting a deficit at the level of the brainstem.…”

Section: Correlation Of Gap-detection Thresholds and Audiometric Thrementioning

confidence: 59%

“…At advanced age, some old humans and some old mice retain excellent temporal resolution while some individuals show impaired performance. In a recent ABR study in gerbils using gap stimuli, Boettcher et al (1996) demonstrated age-specific latency shifts of wave IV in response to the stimulus following the gap and concluded that temporal processing at the level of the brain stem is affected in old animals. Using the same methods, Poth et al (2001) showed that a subpopulation of older human subjects with normal pure-tone thresholds showed similar deficits in the response to gap stimuli at the level of the brain stem.…”

Section: Gap Detection and Agingmentioning

confidence: 99%

“…In contrast to chinchilla and guinea pig, gerbils have a shorter life span of 3-4 years (Cheal 1986), which makes them more practical for studying the effects of aging. Another advantage is that many studies have already investigated various aspects of age-dependent changes in the auditory system of the gerbil (e.g., Henry et al 1980;Czibulka and Schwartz 1991;Tarnowski et al 1991;Schulte and Schmiedt 1992;Boettcher et al 1993Boettcher et al , 1996Gratton et al 1995Gratton et al , 1996Hellstrom and Schmiedt 1996;Schmiedt et al 1996;Sinnott et al 1997;Gleich and Strutz 2002;Hamann et al 2002). Among these, the study by Boettcher et al (1996) using auditory brainstem recordings already provides physiological data on the effect of age on temporal resolution in the gerbil.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Hamann

Gleich

Klump

et al. 2004

JARO - Journal of the Association for Research in Otolaryngolog

View full text Add to dashboard Cite

Gap detection using broadband noise was characterized in a group of young gerbils from the breeding colony of the University of Regensburg (RB gerbils), old RB gerbils, and old gerbils from the breeding colony of the University of South Carolina (SC gerbils). Data from old RB and old SC gerbils were not significantly different and were subsequently combined for a comparison with data from the group of young RB gerbils. Level dependence of gap-detection thresholds in young and old domesticated gerbils resembled the typical mammalian pattern of level dependence. Gap-detection thresholds of old gerbils were significantly elevated at 30 dB SL and 50 dB SPL as compared with young gerbils. Compared with young gerbils tested at 30 dB SL and 50 dB SPL, the distribution of gap-detection thresholds in old gerbils was broader with a spread to higher gap-detection thresholds. Some old animals retained excellent temporal resolution, while some showed impaired gap detection. The gap-detection data collected in young and old gerbils resemble previously published data from humans of different age and confirm that gerbils are a useful model to study age-dependent changes in temporal processing.

show abstract

Section: Correlation Of Gap-detection Thresholds and Audiometric Thrementioning

confidence: 59%

Section: Gap Detection and Agingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Hamann

Gleich

Klump

et al. 2004

JARO - Journal of the Association for Research in Otolaryngolog

View full text Add to dashboard Cite

show abstract

“…Finlayson (2002) measured post-stimulatory suppression in the IC single units of old rats and found that recovery occurred with a mean time constant of 101 ms, compared to 71 ms mean time constant measured in young rats. Temporal processing deficits have also been reported in old gerbils using far-field recording of responses to gap stimuli (Boettcher et al 1996). In contrast, Tomita et al (2004) found that VOT and MGT were unrelated to SNHL.…”

Section: Effects On Minimum Gap Thresholdsmentioning

confidence: 89%

Sensorineural Hearing Loss and Neural Correlates of Temporal Acuity in the Inferior Colliculus of the C57bl/6 Mouse

Walton

Barsz

Wilson

2007

JARO

View full text Add to dashboard Cite

Perception of complex sounds depends on the encoding of the dynamic and static structures within the ongoing stimulus by the auditory system. Aging has been associated with deficits in both areas, thus, the difficulty that the elderly have in speech comprehension could due to hearing loss, or to a loss of temporal sensitivity, or some combination of both. We investigated the effects of sensorineural hearing loss (SNHL) on neural correlates of temporal resolution by recording the responses of inferior colliculus neurons to a gap detection paradigm. We used C57BL/6 (C57) strain of laboratory mouse, which carries the Ahl deafness gene that initiates a progressive high frequency SNHL beginning at about 2 months of age and rapidly progresses to total deafness by 18 months. We compared gap encoding from inferior collicular neurons from young, normal-hearing C57 mice and middle-aged, hearing-impaired, C57 mice, quantifying minimal gap threshold, and recovery functions. The proportion of unit types, spontaneous rates and degree of monotonicity were comparable between young and middle-aged C57 mice. As expected, single unit thresholds were elevated by 30-40 dB in middleaged C57 mice. However, no significant differences in mean minimal gap thresholds or in the slopes of the gap recovery functions were found between the two age groups. Thus, the results suggest that moderate high frequency SNHL does not affect temporal processing as measured by the gap detection paradigm.

show abstract

“…Another approach to studying the problem of age-related changes in auditory temporal resolution is the use of electrophysiological methods, when either neuronal activity or evoked potentials are recorded in response to a gap in noise or to two acoustic stimuli separated by various gaps [28,[30][31][32][33] or to a train of acoustical stimuli with different repetition rates [34][35][36][37]. The results of electrophysiological studies have demonstrated abnormal temporal processing in the central auditory system of aged animals [28,31,33,36,38,39].…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

View full text Add to dashboard Cite

ACCEPTED MANUSCRIPTABBREVIATIONS: dB SPL -dB sound pressure level, GDDL -gap duration difference limen, GDT-gap detection threshold, MLR -middle latency response ABSTRACT Presbycusis, as the deterioration of hearing ability occurring with aging, can be manifested not only in a shift of hearing thresholds, but also in a deterioration of the temporal processing of acoustical signals, which may in elderly people result in degraded speech comprehension.In this study we assessed the age-related changes in the temporal processing of acoustical signals in the auditory system of pigmented rats (Long Evans strain). The temporal resolution was investigated in young adult (3-4 months) and old (30-34 months) rats by behavioral and electrophysiological methods: the rats' ability to detect and discriminate gaps in a continuous noise was examined behaviorally, and the amplitude-rate function was assessed for the middle latency response (MLR) to clicks. A worsening of the temporal resolution with aging was observed in the results of all tests. The values of the gap detection threshold (GDT) and the gap duration difference limen (GDDL) in old rats increased about two-fold in comparison with young adult rats. The MLR to a click train in old rats exhibited a significantly faster reduction in amplitude with an increasing stimulation rate in comparison with young adult rats. None of the age-related changes in the parameters characterizing temporal resolution (GDT, GDDL and MLR to a click train) correlated with the degree of the age-related hearing loss. However, the age-related changes in MLR amplitude-rate function correlated with the age-related changes in GDDL, but not with the changes in GDT. The behavioral and electrophysiological data clearly show that aging in rats is accompanied with a pronounced deficit in the temporal processing of acoustical signals that is associated with the deteriorated function of the central auditory system.

show abstract

Auditory evoked potentials in aged gerbils: responses elicited by noises separated by a silent gap

Cited by 76 publications

References 42 publications

Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Sensorineural Hearing Loss and Neural Correlates of Temporal Acuity in the Inferior Colliculus of the C57bl/6 Mouse

Age-related changes in auditory temporal processing in the rat

Contact Info

Product

Resources

About