Auditory Feedback Control of Vocal Pitch in Spasmodic Dysphonia

Thomas, Arthur S.; Mirza, Natasha; Eliades, Steven J.

doi:10.1002/lary.29254

Cited by 11 publications

(16 citation statements)

References 43 publications

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“…Behaviourally, in the current study, patients and controls showed similar compensatory vocal responses, in spite of significant neural activation differences. In contrast to the current behavioural findings, a recent study found that patients with LD have a larger and earlier vocal pitch compensation response to pitch feedback perturbation 66 . However, there are a few notable differences in the stimuli between the two studies; the pitch shift in Thomas et al 66 was 200 cents (100 cents here) and lasted for 200ms (400ms here).…”

Section: Behavioural Responses To Pitch Feedback Perturbationscontrasting

confidence: 99%

“…In contrast to the current behavioural findings, a recent study found that patients with LD have a larger and earlier vocal pitch compensation response to pitch feedback perturbation 66 . However, there are a few notable differences in the stimuli between the two studies; the pitch shift in Thomas et al 66 was 200 cents (100 cents here) and lasted for 200ms (400ms here). The patients participating in our study were all pre-botox whereas Thomas et al 66 recruited patients before and after botox.…”

Section: Behavioural Responses To Pitch Feedback Perturbationscontrasting

confidence: 99%

“…However, there are a few notable differences in the stimuli between the two studies; the pitch shift in Thomas et al 66 was 200 cents (100 cents here) and lasted for 200ms (400ms here). The patients participating in our study were all pre-botox whereas Thomas et al 66 recruited patients before and after botox.…”

Section: Behavioural Responses To Pitch Feedback Perturbationsmentioning

confidence: 70%

“…72 However, there are a few notable differences in the stimuli between the two studies; the pitch shift in Thomas et al 72 was 200 cents (100 cents here) and lasted for 200ms (400ms here). The patients participating in our study were all pre-botox whereas Thomas et al 72 recruited patients before and after botox. Nevertheless, discrepancies in behavioural findings between the current study and those of Thomas et al 72 warrant further follow-up in larger LD cohorts.…”

Section: Behavioural Responses To Pitch Feedback Perturbationsmentioning

confidence: 72%

“…The patients participating in our study were all pre-botox whereas Thomas et al 72 recruited patients before and after botox. Nevertheless, discrepancies in behavioural findings between the current study and those of Thomas et al 72 warrant further follow-up in larger LD cohorts. We also found that patients had a significantly lower L-DDK rate and that their mean compensatory response to pitch feedback perturbation negatively correlated with their L-DDK rate.…”

Section: Behavioural Responses To Pitch Feedback Perturbationsmentioning

confidence: 99%

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Temporal specificity of abnormal neural oscillations during phonatory events in Laryngeal Dystonia

Kothare

Schneider²,

Mizuiri

et al. 2021

Preprint

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Laryngeal Dystonia is a debilitating disorder of voicing in which the laryngeal muscles are intermittently in spasm resulting in involuntary interruptions during speech. The central pathophysiology of laryngeal dystonia, underlying computational impairments in vocal motor control, remains poorly understood. Although prior imaging studies have found aberrant activity in the central nervous system during phonation in patients with laryngeal dystonia, it is not known at what timepoints during phonation these abnormalities emerge and what function may be impaired. To investigate this question, we recruited 22 adductor laryngeal dystonia patients (15 female, age range = 28.83-72.46 years) and 18 controls (8 female, age range = 27.40-71.34 years). We leveraged the fine temporal resolution of magnetoencephalography to monitor neural activity around glottal movement onset, subsequent voice onset and after the onset of pitch feedback perturbations. We examined event-related beta-band (12-30 Hz) and high-gamma band (65-150 Hz) neural oscillations. Prior to glottal movement onset, we observed abnormal frontoparietal motor preparatory activity. After glottal movement onset, we observed abnormal activity in somatosensory cortex persisting through voice onset. Prior to voice onset and continuing after, we also observed abnormal activity in the auditory cortex and the cerebellum. After pitch feedback perturbation onset, we observed no differences between controls and patients in their behavioural responses to the perturbation. But in patients, we did find abnormal activity in brain regions thought to be involved in the auditory feedback control of vocal pitch (premotor, motor, somatosensory and auditory cortices). Our study results confirm the abnormal processing of somatosensory feedback that has been seen in other studies. However, there were several remarkable findings in our study. First, patients have impaired vocal motor activity even before glottal movement onset, suggesting abnormal movement preparation. These results are significant because: (i) they occur before movement onset, abnormalities in patients cannot be ascribed to deficits in vocal performance, and (ii) they show that neural abnormalities in laryngeal dystonia are more than just abnormal responses to sensory feedback during phonation as has been hypothesised in some previous studies. Second, abnormal auditory cortical activity in patients begins even before voice onset, suggesting abnormalities in setting up auditory predictions before the arrival of auditory feedback at voice onset. Generally, activation abnormalities identified in key brain regions within the speech motor network around various phonation events not only provide temporal specificity to neuroimaging phenotypes in laryngeal dystonia but also may serve as potential therapeutic targets for neuromodulation.

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Section: Behavioural Responses To Pitch Feedback Perturbationscontrasting

confidence: 99%

Section: Behavioural Responses To Pitch Feedback Perturbationscontrasting

confidence: 99%

Section: Behavioural Responses To Pitch Feedback Perturbationsmentioning

confidence: 70%

Section: Behavioural Responses To Pitch Feedback Perturbationsmentioning

confidence: 72%

Section: Behavioural Responses To Pitch Feedback Perturbationsmentioning

confidence: 99%

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Temporal specificity of abnormal neural oscillations during phonatory events in Laryngeal Dystonia

Kothare

Schneider²,

Mizuiri

et al. 2021

Preprint

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Effects of Cortical Stimulation on Feedback‐Dependent Vocal Control in Non‐Human Primates

Eliades

Tsunada

2022

The Laryngoscope

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Objectives Hearing plays an important role in our ability to control voice, and perturbations in auditory feedback result in compensatory changes in vocal production. The auditory cortex (AC) has been proposed as an important mediator of this behavior, but causal evidence is lacking. We tested this in an animal model, hypothesizing that AC is necessary for vocal self‐monitoring and feedback‐dependent control, and that altering activity in AC during vocalization will interfere with vocal control. Methods We implanted two marmoset monkeys (Callithrix jacchus) with bilateral AC electrode arrays. Acoustic signals were recorded from vocalizing marmosets while altering vocal feedback or electrically stimulating AC during random subsets of vocalizations. Feedback was altered by real‐time frequency shifts and presented through headphones and electrical stimulation delivered to individual electrodes. We analyzed recordings to measure changes in vocal acoustics during shifted feedback and stimulation, and to determine their interaction. Results were correlated with the location and frequency tuning of stimulation sites. Results Consistent with previous results, we found electrical stimulation alone evoked changes in vocal production. Results were stronger in the right hemisphere, but decreased with lower currents or repeated stimulation. Simultaneous stimulation and shifted feedback significantly altered vocal control for a subset of sites, decreasing feedback compensation at some and increasing it at others. Inhibited compensation was more likely at sites closer to vocal frequencies. Conclusions Results provide causal evidence that the AC is involved in feedback‐dependent vocal control, and that it is sufficient and may also be necessary to drive changes in vocal production. Level of Evidence N/A Laryngoscope, 133:1–10, 2023

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“Lombard Effect” and Voice Changes in Adductor Laryngeal Dystonia: A Pilot Study

Marchese,

Longobardi,

Libero

et al. 2024

The Laryngoscope

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ObjectivesThe aim was to describe the acoustic, auditory‐perceptive, and subjective voice changes under the Lombard effect (LE) in adductor laryngeal dystonia (AdLD) patients.MethodsSubjective perception of vocal effort (OMNI Vocal Effort Scale OMNI‐VES), Maximum Phonation Time (MPT), and the perceptual severity of dysphonia (GRBAS scale) were assessed in condition of stillness and under LE in 10 AdLD patients and in 10 patients with typical voice. Speakers were asked to produce the sustained vowel /a/ and to read a phonetically balanced text aloud. Using the PRAAT software, the following acoustic parameters were analyzed: Mean Pitch (Hz), Minimum and Maximum Intensity (dB), the Fraction of Locally Unvoiced Frames, the Number of Voice Breaks, the Degree of Voice Breaks (%), the Cepstral Peak Prominence‐Smoothed (CPPS) (dB).ResultsUnder LE, the AdLD group showed a decrease of both G and S parameters of GRBAS and subjective effort, mean MPT increased significantly; in the controls there were no significant changes. In both groups under LE, pitch and intensity of the sustained vowel /a/ significantly increased consistently with LE. In the AdLD group the mean gain of OMNI‐VES score and the mean gain of each parameter of the speech analysis were significantly greater than the controls' ones.ConclusionAuditory feedback deprivation obtained under LE improves subjective, perceptual‐auditory, and acoustics parameters of AdLD patients. These findings encourage further research to provide new knowledge into the role of the auditory system in the pathogenesis of AdLD and to develop new therapeutic strategies.Level of Evidence4 Laryngoscope, 2024

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Auditory Feedback Control of Vocal Pitch in Spasmodic Dysphonia

Cited by 11 publications

References 43 publications

Temporal specificity of abnormal neural oscillations during phonatory events in Laryngeal Dystonia

Temporal specificity of abnormal neural oscillations during phonatory events in Laryngeal Dystonia

Effects of Cortical Stimulation on Feedback‐Dependent Vocal Control in Non‐Human Primates

“Lombard Effect” and Voice Changes in Adductor Laryngeal Dystonia: A Pilot Study

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