Auditory function in the C3H/HeJ and C3H/HeSnJ mouse strains

Trune, Dennis R.; Kempton, J. Beth; Mitchell, Curtin R.

doi:10.1016/0378-5955(96)00017-2

Cited by 23 publications

(26 citation statements)

References 5 publications

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“…Previous study showed that C3H mouse maintained excellent cochlear function throughout the Wrst year of his age [14]. Animals were randomly assigned to serve as control or as noise-exposed subjects.…”

Section: Animals and Experimental Groupsmentioning

confidence: 99%

Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice

Cui

Sun

Yamashita

et al. 2011

Eur Arch Otorhinolaryngol

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Fibrocytes of the spiral limbus are thought to play a significant role in maintaining ion homeostasis in the cochlea. The present study measured physiological and morphological changes in spiral limbus of mice in response to noise exposure. 6-week-old male C3H/HeJJcl mice were exposed to octave-band noise (120 dB SPL) for 2 h and evaluated at a series of times thereafter, up to 8 weeks. Permanent hearing loss resulted in the mice, as assessed by auditory brainstem response (ABR) recordings. The fibrocytes loss was found in the spiral limbus of the apical turn, which has been proved to be induced by apoptosis. These results suggest that noise exposure might result in apoptosis of fibrocytes in spiral limbus, which suggest a mechanism for noise-induced hearing loss.

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Section: Animals and Experimental Groupsmentioning

confidence: 99%

Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice

Cui

Sun

Yamashita

et al. 2011

Eur Arch Otorhinolaryngol

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“…Assessment of hearing acuity in mice is done in many studies (e.g., Ou et al, 2000;Rusch et al, 2001;Trune et al, 1996;Zheng et al, 1999) by measuring the auditory brainstem response (ABR) thresholds. Invariably those assessments are done in anesthetized animals.…”

Section: Introductionmentioning

confidence: 99%

Impact of conventional anesthesia on auditory brainstem responses in mice

et al. 2004

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“…It was previously shown that 32-and 48-week old C3HeB/FeJ mice have hearing thresholds that are comparable to those of CBA/CaJ mice (Noben-Trauth et al, 2003;Zheng et al, 1999). Furthermore, C3H/HeJ and C3H/HeSnJ mice show normal hearing sensitivities up to 56 weeks of age, but have slightly elevated thresholds at 72 weeks of age (Trune et al, 1996). However, preliminary ABR data obtained on 2-year old C3HeB/FeJ mice in our laboratory suggest that this strain is comparable to the CBA/CaJ with thresholds of 20 dB SPL and 55 dB SPL at the 16-and 32 kHz stimulus, respectively (unpublished observations).…”

Section: Discussionmentioning

confidence: 84%