Auditory gating deficit to human voices in schizophrenia: A MEG study

Hirano, Yoji; Hirano, Shogo; Maekawa, Toshihiko; Obayashi, Choji; Oribe, Naoya; Monji, Akira; Kasai, Kiyoto; Kanba, Shigenobu; Onitsuka, Toshiaki

doi:10.1016/j.schres.2009.09.003

Cited by 49 publications

(37 citation statements)

References 52 publications

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“…We suggest 3 possibilities that might explain this unexpected result. First, the left Q2/Q1 ratio in the controls in our study is almost comparable to that of previous MEG studies (Weiland et al, 2008;Hirano et al, 2010). Unlike the findings of previous studies, the left Q2/Q1 was also significantly lower than the right Q2/ Q1 ratio; this finding can be attributed to binaural stimulation (Hirano et al, 2010;Lu et al, 2007;Hanlon et al, 2005;Thoma et al, 2003).…”

Section: Pws Cannot "Gate Out"supporting

confidence: 84%

“…To validate our hypothesis, we conducted 3 experiments. First, we examined auditory sensory gating by MEG using a P50m (or P50 in EEG) suppression standard paradigm, as has been used in studies on schizophrenia and Alzheimer's disease (Adler et al, 1982;Jessen et al, 2001;Thoma et al, 2003;Hirano et al, 2010). We presented 2 successive click sounds to the subjects monaurally, and the lack of P50m suppression in response to the second sound suggested an inability to filter unnecessary auditory information.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…For estimating the ECD of P50m, 10-ms data across the time point showing the maximal amplitude of P50m were selected from the RMS waveforms, and the ECDs with the largest dipole moment over the period were selected. The calculated ECD strengths and locations were accepted for further analysis when they satisfied the following criteria: (1) a P50m peak latency between 20 and 70 ms, and (2) a goodness-of-fit greater than 75% (Hirano et al, 2008(Hirano et al, , 2010Thoma et al, 2003). P50m suppression was expressed as a ratio of the P50m dipole moment evoked by S2 (Q2) to that evoked by S1 (Q1).…”

Section: Meg Recordingmentioning

confidence: 99%

“…A lack of P50m (or P50) suppression has been proposed as the index of abnormal auditory sensory gating (or "gate out") in schizophrenia (Adler et al, 1982;Thoma et al, 2003;Hirano et al, 2010) and Alzheimer's disease (Jessen et al, 2001). We first demonstrated the left hemispheric impairment of P50m suppression in PWS; this finding indicates that the normally present inhibitory mechanisms are markedly reduced in PWS and supports our working hypothesis that PWS cannot gate out ignorable auditory inputs, which lead to errors.…”

Section: Pws Cannot "Gate Out"mentioning

confidence: 99%

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Spatiotemporal signatures of an abnormal auditory system in stuttering

et al. 2011

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People who stutter (PWS) can reduce their stuttering rates under masking noise and altered auditory feedback; such a response can be attributed to altered auditory input, which suggests that abnormal speech processing in PWS results from abnormal processing of auditory input. However, the details of this abnormal processing of basic auditory information remain unclear. In order to characterize such abnormalities, we examined the functional and structural changes in the auditory cortices of PWS by using a 306-channel magnetoencephalography system to assess auditory sensory gating (P50m suppression) and tonotopic organization. Additionally, we employed voxel-based morphometry to compare cortical gray matter (GM) volumes on structural MR images. PWS exhibited impaired left auditory sensory gating. The tonotopic organization in the right hemisphere of PWS is expanded compared with that of the controls. Furthermore, PWS showed a significant increase in the GM volume of the right superior temporal gyrus, consistent with the right tonotopic expansion. Accordingly, we suggest that PWS have impaired left auditory sensory gating during basic auditory input processing and that some error signals in the auditory cortex could result in abnormal speech processing. Functional and structural reorganization of the right auditory cortex appears to be a compensatory mechanism for impaired left auditory cortex function in PWS.

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Section: Pws Cannot "Gate Out"supporting

confidence: 84%

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Section: Meg Recordingmentioning

confidence: 99%

Section: Pws Cannot "Gate Out"mentioning

confidence: 99%

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Spatiotemporal signatures of an abnormal auditory system in stuttering

et al. 2011

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“…The P50 is a positive potential occurring around 50 ms after presentation of auditory stimuli (A), and it has been especially studied as a potential index of sensory gating in schizophrenia [17,18,19]. Recent human and animal studies have also demonstrated that changes in P50 signal early deviance detection for A (for a review, see [20]).…”

Section: Introductionmentioning

confidence: 99%

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

et al. 2015

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Objective: Unconscious fast integration of face and voice information is a crucial brain function necessary for communicating effectively with others. Here, we investigated for evidence of rapid face-voice integration in the auditory cortex. Methods: Magnetic fields (P50m and N100m) evoked by visual stimuli (V), auditory stimuli (A) and audiovisual stimuli (VA), i.e. by face, vowel and simultaneous vowel-face stimuli, were recorded in 22 healthy subjects. Magnetoencephalographic data from 28 channels around bilateral auditory cortices were analyzed. Results: In both hemispheres, AV - V showed significantly larger P50m amplitudes than A. Additionally, compared with A, the N100m amplitudes and dipole moments of AV - V were significantly smaller in the left hemisphere, but not in the right hemisphere. Conclusions: Differential changes in P50m (bilateral) and N100m (left hemisphere) that occur when V (faces) are associated with A (vowel sounds) indicate that AV (face-voice) integration occurs in early processing, likely enabling us to communicate effectively in our lives.

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Physiological Correlates of Positive Symptoms in Schizophrenia

Galderisi¹,

Vignapiano²,

Mucci³

et al. 2014

Current Topics in Behavioral Neurosciences

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Patients with schizophrenia have been hypothesized to have a functional impairment in filtering irrelevant sensory information, which may result in positive symptoms such as hallucinations or delusions. Many evidences suggest that abnormalities in the event-related brain potentials (ERPs), resting state electroencephalography (EEG) and synchronized oscillatory activity of neurons may reflect core pathophysiological mechanisms of schizophrenia. Abnormalities in amplitude and latency of the ERPs reflecting aberrations in gating and difficulties in the detection of changes in auditory stimuli, as well as defects in stimuli evaluation and integration of information are common in patients with schizophrenia. This chapter highlights the findings of electrophysiological studies in schizophrenia dealing with early sensory perception and attention, automatic sensory detection of stimuli changes and cognitive evaluation and integration of information, relevant to the pathophysiological mechanisms underpinning hallucinations and delusions. Results of electrophysiological studies investigating the neural correlates of positive symptoms suggest aberrant intrinsic organization of functional brain networks.

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Auditory gating deficit to human voices in schizophrenia: A MEG study

Cited by 49 publications

References 52 publications

Spatiotemporal signatures of an abnormal auditory system in stuttering

Spatiotemporal signatures of an abnormal auditory system in stuttering

Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation

Physiological Correlates of Positive Symptoms in Schizophrenia

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