Auditory Processing of Older Adults With Probable Mild Cognitive Impairment

Edwards, Jerri D.; Lister, Jennifer J.; Elías, Maya N.; Tetlow, Amber M.; Sardina, Angela; Sadeq, Nasreen A.; Brandino, Amanda D.; Bush, Aryn L. Harrison

doi:10.1044/2016_jslhr-h-16-0066

Cited by 44 publications

(28 citation statements)

References 49 publications

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“…Hearing loss is generally considered as an increase in average pure tone thresholds. But hearing ability is beyond pure tone sensitivity and includes more factors such as frequency selectivity, temporal coding fidelity, temporal encoding, intensity resolution, loudness, etc., which are not normally measured during an audiometric evaluation [6]. As we expected, the results of this study showed that speech perception in quiet did not differ significantly between the two groups.…”

Section: Discussionsupporting

confidence: 60%

“…Previous studies have provided evidence of impairment in central auditory processing in individuals with MCI. It has been shown that their hearing performance is lower than expected, especially in the presence of background noise or competitive noise [6]. According to previous studies, it seems that central auditory processing disorders (CAPDs) are more common in older people who are more likely to develop cognitive problems, including MCI and Alzheimer’s disease [7].…”

Section: Introductionmentioning

confidence: 99%

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Central Auditory Processing Tests as Diagnostic Tools for the Early Identification of Elderly Individuals with Mild Cognitive Impairment

et al. 2019

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Background and Objectives Mild cognitive impairment (MCI) is a disorder that usually occurs in the elderly, leading to dementia in some progressive cases. The purpose of this study is to examine the utility of central auditory processing tests as early diagnostic tools for identifying the elderly with MCI. Subjects and Methods This study was conducted on 20 elderly patients with MCI and 20 healthy matched peers. The speech perception ability in a quiet environment and in the presence of background noise and also temporal resolution were assessed by using Speech Perception in Noise (SPIN) and Gap in Noise (GIN) tests, respectively. Results The results indicated that the ability to understand speech in a quiet environment did not differ significantly between the two groups. However, SPIN at the three signal-tonoise ratios and the temporal resolution scores were significantly different between the two groups ( p <0.001). Conclusions Individuals with MCI appear to have poorer speech comprehension in noise and a lower temporal resolution than those of the same age, but without cognitive defects. Considering the utility of these tests in identifying cognitive problems, we propose that since the GIN test seems to be less influenced by intervening factors, this test can therefore, be a useful tool for the early screening of elderly people with cognitive problems.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Central Auditory Processing Tests as Diagnostic Tools for the Early Identification of Elderly Individuals with Mild Cognitive Impairment

et al. 2019

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“…As well, presumably because of neurodegenerative deficits in inter-hemispheric communication or integrity [ 37 ], they may display a disproportionate “right ear advantage”, i.e., decreased comprehension of information presented to the left ear [ 27, 38 ]. MCI patients typically show similar but lesser difficulties [ 39 ] that are, nonetheless, distinct from those associated with subjective memory complaints only [ 25 ]. Importantly, impairment in these abilities in symptomatic persons is related to areas of the brain that are particularly vulnerable to AD neurodegeneration [ 29–31 ].…”

Section: Introductionmentioning

confidence: 99%

Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer’s Disease

Tuwaig

Savard

Jutras

et al. 2017

JAD

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Prevention of dementia due to Alzheimer’s disease (d/AD) requires interventions that slow the disease process prior to symptom onset. To develop such interventions, one needs metrics that assess pre-symptomatic disease progression. Familiar measures of progression include cerebrospinal fluid (CSF) biochemical and imaging analyses, as well as cognitive testing. Changes in the latter can sometimes be difficult to distinguish from effects of “normal” aging. A different approach involves testing of “central auditory processing” (CAP), which enables comprehension of auditory stimuli amidst a distracting background (e.g., conversation in a noisy bar or restaurant). Such comprehension is often impaired in d/AD. Similarly, effortful or diminished auditory comprehension is sometimes reported by cognitively healthy elders, raising the possibility that CAP deficit may be a marker of pre-symptomatic AD. In 187 cognitively and physically healthy members of the aging, AD family history-positive PREVENT-AD cohort, we therefore evaluated whether CAP deficits were associated with known markers of AD neurodegeneration. Such markers included CSF tau concentrations and magnetic resonance imaging volumetric and cortical thickness measures in key AD-related regions. Adjusting for age, sex, education, pure-tone hearing, and APOE ɛ4 status, we observed a persistent relationship between CAP scores and CSF tau levels, entorhinal and hippocampal cortex volumes, cortical thickness, and deficits in cognition (Repeatable Battery for Assessment of Neuropsychological Status total score, and several of its index scales). These cross-sectional observations suggest that CAP may serve as a novel metric for pre-symptomatic AD pathogenesis. They are therefore being followed up longitudinally with larger samples.

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“…The SSI-ICM test appears to be sensitive to the decline of CAP skills in MCI populations and accurately predicts the future clinical diagnosis of AD (Gates et al, 2008 andEdwards et al, 2017). Gates et al (2008) found that individuals with a diagnosis of MCI performed significantly poorer on the 0 dB SNR condition of the SSI-ICM compared to a control group.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have previously investigated the CAP skills in individuals diagnosed with MCI (Idrizbegovic et al, 2013;Edwards et al, 2017) and dementia (Gates et al, 2011;Golden et al, 2015;Quaranta et al, 2015). However, to date, no study has investigated the CAP skills in individuals with subjective memory complaints (SMCs).…”

Section: Introductionmentioning

confidence: 99%

The Peripheral Hearing and Central Auditory Processing Skills of Individuals With Subjective Memory Complaints

et al. 2020

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This study examined the central auditory processing (CAP) assessment results of adults between 45 and 85 years of age with probable pre-clinical Alzheimer's disease-i.e., individuals with subjective memory complaints (SMCs) as compared to those who were not reporting significant levels of memory complaints (non-SMCs). It was hypothesized that the SMC group would perform significantly poorer on tests of central auditory skills compared to participants with non-SMCs (control group). Methods: A total of 95 participants were recruited from the larger Western Australia Memory Study and were classified as SMCs (N = 61; 20 males and 41 females, mean age 71.47 ±7.18 years) and non-SMCs (N = 34; 10 males, 24 females, mean age 68.85 ±7.69 years). All participants completed a peripheral hearing assessment, a CAP assessment battery including Dichotic Digits, Duration Pattern Test, Dichotic Sentence Identification, Synthetic Sentence Identification with Ipsilateral Competing Message (SSI-ICM) and the Quick-Speech-in-Noise, and a cognitive screening assessment. Results: The SMCs group performed significantly poorer than the control group on SSI-ICM −10 and −20 dB signal-to-noise conditions. No significant differences were found between the two groups on the peripheral hearing threshold measurements and other CAP assessments. Conclusions: The results suggest that individuals with SMCs perform poorly on specific CAP assessments in comparison to the controls. The poor CAP in SMC individuals may result in a higher cost to their finite pool of cognitive resources. The CAP results

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Auditory Processing of Older Adults With Probable Mild Cognitive Impairment

Abstract: Older adults with cognitive impairment not only have difficulty with competing acoustic signals but may also show poor temporal processing. The profile of auditory processing deficits among older adults with cognitive impairment may include multiple domains.

Cited by 44 publications

References 49 publications

Central Auditory Processing Tests as Diagnostic Tools for the Early Identification of Elderly Individuals with Mild Cognitive Impairment

Central Auditory Processing Tests as Diagnostic Tools for the Early Identification of Elderly Individuals with Mild Cognitive Impairment

Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer’s Disease

The Peripheral Hearing and Central Auditory Processing Skills of Individuals With Subjective Memory Complaints

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