Augmentation for Cell Spreading and Migration by A Soluble Fraction of Cotton-Derived Carboxymethyl Cellulose

Aoshima, Motonori; Jo, Yoshio

doi:10.1295/koron.70.273

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…To date, a tremendous amount of research evidence has supported the feasibility of the application of CMC-based biomaterials for bone tissue engineering and bone regeneration purposes. For instance, Aoshima and Jo (2013) [305] demonstrated an in vitro stimulation of CMC compounds for adhesion and proliferation of mouse fibroblasts. Clarke and his co-workers (2007) [306] reported that the presence of CMC in calcium phosphate (β-TCP) granules enhanced the activity of alkaline phosphate (ALP) and proliferation of stromal cells in the human bone marrow.…”

Section: Bone-tissue Engineeringmentioning

confidence: 99%

Recent Developments of Carboxymethyl Cellulose

et al. 2021

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Carboxymethyl cellulose (CMC) is one of the most promising cellulose derivatives. Due to its characteristic surface properties, mechanical strength, tunable hydrophilicity, viscous properties, availability and abundance of raw materials, low-cost synthesis process, and likewise many contrasting aspects, it is now widely used in various advanced application fields, for example, food, paper, textile, and pharmaceutical industries, biomedical engineering, wastewater treatment, energy production, and storage energy production, and storage and so on. Many research articles have been reported on CMC, depending on their sources and application fields. Thus, a comprehensive and well-organized review is in great demand that can provide an up-to-date and in-depth review on CMC. Herein, this review aims to provide compact information of the synthesis to the advanced applications of this material in various fields. Finally, this article covers the insights of future CMC research that could guide researchers working in this prominent field.

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Section: Bone-tissue Engineeringmentioning

confidence: 99%

Recent Developments of Carboxymethyl Cellulose

et al. 2021

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“…In addition, microfibrillated cellulose remarkably increases the surface area, and its interfibrillar hydrogen bonds facilitate network formation, which is desirable in bone tissue engineering (Ionițȃ et al 2018). Moreover, CMC stimulates adhesion, spreading, and migration of mouse fibroblasts in vitro (Adachi et al 1992;Aoshima and Jo 2013). Also, the presence of CMC decreases osteoclastogenesis by murine bone marrow progenitors (Agis et al 2010), but increases osteoblast differentiation (Qi et al 2018).…”

Section: Tissue Engineeringmentioning

confidence: 99%

Cellulose and its derivatives: towards biomedical applications

et al. 2021

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Cellulose is the most abundant polysaccharide on Earth. It can be obtained from a vast number of sources, e.g. cell walls of wood and plants, some species of bacteria, and algae, as well as tunicates, which are the only known cellulose-containing animals. This inherent abundance naturally paves the way for discovering new applications for this versatile material. This review provides an extensive survey on cellulose and its derivatives, their structural and biochemical properties, with an overview of applications in tissue engineering, wound dressing, and drug delivery systems. Based on the available means of selecting the physical features, dimensions, and shapes, cellulose exists in the morphological forms of fiber, microfibril/nanofibril, and micro/nanocrystalline cellulose. These different cellulosic particle types arise due to the inherent diversity among the source of organic materials or due to the specific conditions of biosynthesis and processing that determine the consequent geometry and dimension of cellulosic particles. These different cellulosic particles, as building blocks, produce materials of different microstructures and properties, which are needed for numerous biomedical applications. Despite having great potential for applications in various fields, the extensive use of cellulose has been mainly limited to industrial use, with less early interest towards the biomedical field. Therefore, this review highlights recent developments in the preparation methods of cellulose and its derivatives that create novel properties benefiting appropriate biomedical applications.

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“…37 It has also been shown that CMC possesses the ability to promote adhesion, spreading, and migration of mouse fibroblasts in vitro. 38 Furthermore, recent insights on the interaction between CMC and osteogenic genes indicated that CMC supports osteogenic differentiation for bone regeneration. 39,40 Bio-inert materials for osteoporosis are eventually removed from the body through secondary surgery.…”

Section: Introductionmentioning

confidence: 99%