Augmentation of Chorionic Gonadotrophin by Polyvinylpyrrolidone

On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry.

“…3 for comparison, although it is noted that strict interpretation of these comparative data is not advisable because of species differences. Experiments involving intravenous injection of penicillin G in rats (9) showed an elimination curve parallel to that for the rat data shown in Fig. 3.…”

Possible Advantages of Highly Purified Penicillin in Avoiding Penicilloyl‐specific Sensitization and Allergic Reactions*

“…Pa&sive transfer tests were performed on 20 youngish, non-allergic human recipients in a good general conditLoii. Procedure, precautions, and reading of the reactions have been described in previous papers (33,34,35). The recipients were sensitized passively to the penicilloyl radical or to penicilloate in pretnarked fields on the back by intracutaneous injections of 0.1 xa\ reagin-cmitatnlng serum.…”

“…Thus, 35-75 per cent of penicillin allergies show positive cutaneous reaction to penicilloyl-polylysine (31, SS^ 44i 40. 10)• More rarely a positive cutaneous reaction to penicillin (12,14,56) and to penicillin as well as penicilloate (53) may be obtained, Corresponding findings are made in searching for skin-sensitizing antibodies-reagins-in the serum of penicillin allergies (34). In such investigations too penicilloyl-specific reactions show the highest incidence.…”

“…That reactions to these 3 chemical compounds-penicillin, the penicilloyl radical, and penicilloate-occur in human penicillin allergy has been demonstrated by cutaneous tests on penicillin allergies (37) and by studying skin-sensitizing antibodies -reagins-in the serum of penicillin allergies (37,34). Cross absorption experiments in passive transfer tests using the 3 compounds have shown with certainty that there is a question of 3 specific antigens, and within wide concentration ranges there have been no definite signs of cross allergy between the 3 antigens or of a mutual inhibition of the induction of positive reactions (35).…”

“…It has not been elucidated, however, whether sufficient peni-ciUoate forms in vivo during penicillin therapy to elicit an allergic reaction. High penicilloate concentrations are required to elicit penicilloate-specific passive transfer tests (34).…”