Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds
Abstract:Docetaxel (DTX) is the treatment of choice for metastatic castration-resistant prostate cancer. However, developing drug resistance is a significant challenge for achieving effective therapy. This study evaluated the anticancer and synergistic effects on DTX of four natural compounds (calebin A, 3′-hydroxypterostilbene, hispolon, and tetrahydrocurcumin) using PC-3 androgen-resistant human prostate cancer cells. We utilized the CellTiter-Glo® luminescent cell viability assay and human PC-3 androgen-independent … Show more
“…183 The combination of THC with docetaxel could augment the toxicity of docetaxel to androgen-resistant PC-3 prostate cancer cells and reduced the docetaxel effective concentration. 184 Combined administration has great potential to improve efficacy, especially in the treatment of tumor resistance. Therefore, the combination of THC and different drugs might provide a new way of administration for clinical therapy.…”
Section: The Combination Of Thc With Other Drugsmentioning
Tetrahydrocurcumin showed potential biological activities in neurologic, cardiovascular, respiratory, liver, metabolic, renal, skin and inflammatory diseases as well as cancer.
“…183 The combination of THC with docetaxel could augment the toxicity of docetaxel to androgen-resistant PC-3 prostate cancer cells and reduced the docetaxel effective concentration. 184 Combined administration has great potential to improve efficacy, especially in the treatment of tumor resistance. Therefore, the combination of THC and different drugs might provide a new way of administration for clinical therapy.…”
Section: The Combination Of Thc With Other Drugsmentioning
Tetrahydrocurcumin showed potential biological activities in neurologic, cardiovascular, respiratory, liver, metabolic, renal, skin and inflammatory diseases as well as cancer.
“…Natural products are a rich source of bioactive molecules endowed by a great variety of chemical scaffolds. Natural compounds are often used in traditional medicine and used to build semisynthetic molecules with improved biological properties [44][45][46]. In this context, Shuvalov and collaborators reviewed the information about plants and mushrooms, as well as their active compounds with antitumor properties.…”
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