Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator

Suresh, K.; Vasudevan, DM

doi:10.1016/0378-8741(94)90099-x

Cited by 91 publications

(35 citation statements)

References 7 publications

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“…Emblica officinalis displays pronounced adaptogenic properties, protecting against free radical damage induced during stress (Rege et al, 1999), and also enhances natural killer cell activity and antibody dependent cytotoxicity in tumour bearing mice, by increasing the life-span 35% beyond that of the control animals (Suresh and Vasudeven, 1994). These, and its …”

Section: Discussionmentioning

confidence: 98%

Radioprotection of Swiss albino mice byEmblica officinalis

et al. 2005

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The fruit pulp of Emblica officinalis (EO) is an important drug used in Indian systems of medicine for several diseases and as a tonic. In view of its multifarious uses, the plant extract (aqueous) was tested for its radioprotective properties against sublethal gamma radiation (9 Gy) in Swiss albino mice. Animals were divided into two groups and irradiated with gamma radiation externally, with or without EO extract, which was given orally at different doses before irradiation. The dose of fruit pulp extract found to be most effective against radiation was 100 mg/kg b.wt. This dose increased the survival time and reduced the mortality rate of mice significantly. Furthermore, body weight loss in EO administered irradiated animals was significantly less in comparison with animals who were given radiation only.

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Section: Discussionmentioning

confidence: 98%

Radioprotection of Swiss albino mice byEmblica officinalis

et al. 2005

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“…It inhibits lipid peroxidation and also acts as scavenger of free radicals. It is rich in active ingredients like tannins, carbohydrates, saponins, ellagic acid, sorbitol and ascorbic acid [17][18][19][20][21][22][23][24][25]. In the present study, an attempt has been made to evaluate the protective role of Triphala on the toxic and carcinogenic damage due to DMH induced ER stress in mouse liver.…”

Section: Introductionmentioning

confidence: 99%

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

Sharma

2011

Ind J Clin Biochem

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The present study was carried out to investigate the protective role of Triphala (a combination in equal proportions by weight of fruit powder of Terminalia belerica, Terminalia chebula and Emblica officinalis) against 1,2-dimethylhydrazinedihydrochloride (DMH) induced Endoplasmic reticulum stress (ER stress) in mouse liver. An oral dose of 3 mg/kg body wt in drinking water for 5 weeks significantly (P \ 0.001) increased the levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum Alkaline phosphatase (ALP) and total bilirubin thus suggesting damage to mouse liver and biliary dysfunction. The DMH administration invariably led to increase in the liver microsomal proteins of molecular weight of about 29 (ERp29) and 53 kDa (ERp53) and decrease in the protein of molecular weight of 36 kDa (ERp36) thereby suggesting the interference of DMH and its metabolites with normal protein biosynthesis and folding, in the reticular membranes of the liver cells thus developing ER stress. Histological studies show necrosis, large sized hepatocytes with increased N:C ratio, aberrant mitotic figures and prominent nucleoli in the liver of DMH treated mice. In animals fed 5% Triphala in diet (w/w) during DMH administration, there was significant decrease in the above changes in the liver suggesting the suppression of DMH induced ER stress in liver. Triphala significantly (P \ 0.05) decreased lipid peroxidation and also the activity of lactate dehydrogenase (LDH) in mouse liver. It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.

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“…According to the manufacturer's statement, this combination has antistress properties and immunomodulation activity resulting in an increased postvaccinal humoral immune response. Active compounds of Magnifera indica, Withania somnifera, Phyllanthus emblica, and Ocimum sanctumas may influence pigs' health and performance due to their antioxidant (6), antibacterial (6), antistress (4,5), anti-inflammatory (6), and immunomodulatory properties (4,20). However, there is a limited research validating their potential benefits for pigs.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary phytogenic product on the performance and immune response of pigs

Pomorska‐Mól

Kwit

Czyzewska

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to determine the effects of supplementation of sows' and weaners' diet with Stresomix, preparation containing extracts from Magnifera indica, Withania somnifera, Phyllanthus emblica, and Ocimum sanctum, on pig performance and immunity under field condition. The hypothesis was that anti-inflammatory, antistress, and immunomodulatory properties of the herbs would enhance production parameters and immune response, according to the manufacturer's claim. The study was performed on 16 sows and 160 piglets. The following parameters were recorded: concentration and proportion of white blood cells and their populations, concentration of serum immunoglobulins, specific humoral postvaccinal response after vaccination against swine influenza and swine erysipelas, and main production parameters. No significant differences among treatment groups were found with regard to concentrations of leukocyte subpopulations and immunoglobulins, as well as all investigated production parameters (P>0.05). In conclusion, the results of the study did not confirm that the investigated polyherbal product, administered at dose recommended by manufacturer, is able to significantly improve the performance and postvaccinal humoral response in clinically healthy pigs under field condition.

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Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a new immunomodulator

Cited by 91 publications

References 7 publications

Radioprotection of Swiss albino mice byEmblica officinalis

Radioprotection of Swiss albino mice byEmblica officinalis

Chemoprotective Role of Triphala Against 1,2-Dimethylhydrazine Dihydrochloride Induced Carcinogenic Damage to Mouse Liver

Effects of dietary phytogenic product on the performance and immune response of pigs

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