Radioprotection of Swiss albino mice byEmblica officinalis

Singh, Inder; Sharma, Abhilasha; Nunia, Vandana; Goyal, Pradeep

doi:10.1002/ptr.1600

Cited by 50 publications

(28 citation statements)

References 6 publications

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“…Recently, and using different methods of assay, there has been an increasing number of reports showing that extracts from plants such as Adhatoda vasica Nees , Amaranthus paniculatus (Krishna & Kumar 2005, Mahargual et al 2005, Centella asiatica , Dioscorea alata L. (Wang et al 2004), Emblica officinalis (Singh et al 2005), Hemidesmus indicus (Shetty et al 2005), Mentha piperita L. (Samarth et al 2004), Piper betel (Bhattacharya et al 2005) Piper longum (Sunila & Kuttan 2005), Rhodiola imbricata Edgew (Arora et al 2005b), Saccharum officinarum L. (Amer et al 2005), Syzygium Cumini (Jagetia et al 2005), Terminalia chebula (Naik et al 2004, Gandhi & Nair 2005 and Tinospora cordifolia (Goel et al 2004) contain biocompounds which are able to be radioprotectors.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the SOS Chromotest in the study of medicinal plants as radioprotectors

Fuentes

Alonso

Cuétara³

et al. 2006

International Journal of Radiation Biology

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Section: Discussionmentioning

confidence: 99%

Usefulness of the SOS Chromotest in the study of medicinal plants as radioprotectors

Fuentes

Alonso

Cuétara³

et al. 2006

International Journal of Radiation Biology

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“…[59] Additionally, the radioprotective effect of EOE was demonstrated from different studies in mice. [60][61][62][63] Analgesic, Antipyretic and Antiinflammatory It has been extensively shown that many plant-derived compounds present substantial anti-inflammatory effects. Hence, they signify prospective molecules for the development of new drugs, particularly designed for the treatment and/or control of chronic inflammatory states such as rheumatism, asthma, inflammatory bowel diseases, atherosclerosis, etc.…”

Section: Metabolic Syndromementioning

confidence: 99%

Emblica officinalis(Amla): A review of potential therapeutic applications

Bhandari¹,

Kamdod²

2012

Int J Green Pharm

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PHYTOCHEMISTRYE. officinalis is one of the most extensively studied plants and reports suggest that it contains tannins, alkaloids, and phenolic compounds. It has been reported that fruits of E. officinalis contains higher amount of vitamin C and considerably higher concentrations of most minerals, protein and amino acids like glutamic acid, proline, aspartic acid, alanine, cystine and lysine. vitamin C levels are more than those in oranges, tangerines, or lemons. Fresh pericarp of E. officinalis contains higher amount of hydrolysable tannins like emblicanin A and B, punigluconin, pedunculagin. Activity-directed fractionation and purification process identified phytochemicals present in E. officinalis. They have identified gallic acid, methyl gallate, corilagin, furosin and geraniin in E. officinalis by a chromatographic and spectroscopic method. Phytochemical investigations revealed that E. officinalis contains higher amount of flavonoid like quercetin. Fruits were also analyzed for their alkaloidal Emblica officinalis Gaertn. or Phyllanthus emblica Linn, commonly known as Indian gooseberry or Amla, is perhaps the most important medicinal plant in the Indian traditional system of medicine, the Ayurveda. Several parts of the plant are used to treat a variety of diseases, but the most important is the fruit. Many ailments are treated by the fruit which is used either alone or in combination with other plants. These include common cold and fever; as a diuretic, laxative, liver tonic, refrigerant, stomachic, restorative, alterative, antipyretic, anti-inflammatory, hair tonic; to prevent peptic ulcer and dyspepsia, and as a digestive. E. officinalis possesses antipyretic, analgesic, antitussive, antiatherogenic, adaptogenic, cardioprotective, gastroprotective, antianemic, antihypercholesterolemic, wound healing, antidiarrheal, antiatherosclerotic, hepatoprotective, nephroprotective, and neuroprotective properties as demonstrated in numerous preclinical studies. Furthermore, experimental studies have reported that E. officinalis and some of its phytochemicals also exhibit anticarcinogenic properties. E. officinalis is also reported to possess radiomodulatory, chemomodulatory, chemopreventive, free radical scavenging, antioxidant, anti-inflammatory, antimutagenic and immunomodulatory activities. These properties are efficacious in the treatment and prevention of cancer. This review summarizes the results related to these properties and also emphasizes the aspects that warrant future research establishing its activity and utility as a cancer preventive and therapeutic drug in humans.

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“…One study reported that alcoholic root extract of Rubia cardifolia provides significant protection against radiation induced lipid peroxidation, haemopoietic injury and genotoxicity 33 . Similarly extracts of Phodophyllum, Emblica officinalis, Tinospora cordifolia and Ginger have shown protection of radiation induced damage to GI and embryonic nervous system and micronuclei formation and oxidative stress in mice respectively [34][35][36] . The protective effects of many compounds against radiation-induced gastrointestinal injuries have been investigated 37 .…”

Section: Radioprotective Natural Productmentioning

confidence: 99%

Radiation Induced Gastrointestinal Damage and Protection: Nigella Sativa Seed Extract and Thymoquinone

et al. 2017

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Ionising radiation therapy is a common treatment for different types of cancers. The side effects associated with radiation includes destruction of normal cells, especially the dividing cells. The cells in the gastrointestinal (GI) tract and bone marrow are the primary targets. The GI damage is reflected by early histological changes, functional alterations and symptoms of nausea, vomiting and diarrhea. This has been designated as the radiation syndrome. Many synthetic drugs have been used to treat GI disorders but a definite cure has not been discovered so far and these available medications also cause several side effects. The herbal extracts are being tested for long time as preventive food supplement/drug in this disease. The radio protective effects of Nigella sativa (black cumin, (Ranunculacea) is already reported but its mechanism of action is not well established. Here in this review this aspect has been explored with special reference to various in vitro and in vivo models.Keyword: Nigella sativa; Thymoquinone; Radioprotector; Herbal; Radiation Defence Life Science Journal, Vol. 2, No. 3, July 2017, pp. 264-269, DOI : 10.14429 REVIEW PAPER265 PANDAY, et al.: DEf. LIfE SCI. J., VOL. 2, NO. 3, JuLY 2017, DOI : 10.14429/dlsj.2.11665 cancers of the skin, cervix, prostate, lungs, thyroid and brain), and may be the only treatment needed to cure the cancer 7 . Nevertheless, radiation therapy remains dose limited by the tolerance of surrounding normal tissues.The gastrointestinal tract (GIT) not only is a major doselimiting organ during abdominal, pelvic, and retroperitoneal radiation therapy 8 but is also one of organs for the outcome of accidental whole-body radiation exposure. An exposure to the dose of 5 Gy -8 Gy, may result to death within few weeks. However low dose in the range of 2 Gy -5 Gy, may result to delayed symptoms especially to the hematopoietic system, resulting immunosuppression and rapid manifestation of infections. The GI damage is another cause of death depending on the dose and severity of damage, including intestinal crypt cell death. Therefore, interventions that reduce gastrointestinal radiation injury are urgently needed. Radiation enteritis is a challenging clinical problem in patients receiving ionising radiation 9 . Clinically, irradiation can result in several deleterious gastro-intestinal symptoms such as bleeding, anorexia, nausea, vomiting and diarrhea i.e. gastrointestinal radiation syndrome 10,11 . The high sensitivity of the GIT to ionising radiation (and other cytotoxic insults) is a dose limiting issue in some radio-and chemotherapy practices. The duodenum is the most radiosensitive region of the digestive tract, followed by jejunum, ileum, esophagus, stomach, colon, and rectum, in order of radiosensetivity 12,13 .The mucosal cells are characterised by rapid proliferation rate and relatively high degree of radiosensetivity. In both animal models and patients, small intestinal and whole gut transit was markedly accelerated within hours after irradiation 14,15 . ...

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Radioprotection of Swiss albino mice byEmblica officinalis

Cited by 50 publications

References 6 publications

Usefulness of the SOS Chromotest in the study of medicinal plants as radioprotectors

Usefulness of the SOS Chromotest in the study of medicinal plants as radioprotectors

Emblica officinalis(Amla): A review of potential therapeutic applications

Radiation Induced Gastrointestinal Damage and Protection: Nigella Sativa Seed Extract and Thymoquinone

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