Augmentation of suture anchors with magnesium phosphate cement – Simple technique with striking effect

Heilig, Philipp; Jordan, Martin; Paul, Mila M.; Kupczyk, Eva; Meffert, Rainer H.; Gbureck, Uwe; Hoelscher-Doht, Stefanie

doi:10.1016/j.jmbbm.2022.105096

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…Furthermore, it has been shown for IP 6-modified MPCs that the resistance of bone anchors implanted in bone to tensile loading can be increased by the addition of such IP 6 MPCs. The underlying mechanism was postulated to be the improved distribution of acting forces in the adjacent bone [ 30 ]. The drillability of cements can be a decisive advantage for bone cements in different fracture patterns.…”

Section: Discussionmentioning

confidence: 99%

Degradation and Bone-Contact Biocompatibility of Two Drillable Magnesium Phosphate Bone Cements in an In Vivo Rabbit Bone Defect Model

Ewald,

Fuchs,

Boegelein

et al. 2023

Materials

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The use of bone-cement-enforced osteosynthesis is a growing topic in trauma surgery. In this context, drillability is a desirable feature for cements that can improve fracture stability, which most of the available cement systems lack. Therefore, in this study, we evaluated a resorbable and drillable magnesium-phosphate (MgP)-based cement paste considering degradation behavior and biocompatibility in vivo. Two different magnesium-phosphate-based cement (MPC) pastes with different amounts of phytic acid (IP 6) as setting retarder (MPC 22.5 and MPC 25) were implanted in an orthotopic defect model of the lateral femoral condyle of New Zealand white rabbits for 6 weeks. After explantation, their resorption behavior and material characteristics were evaluated by means of X-ray diffraction (XRD), porosimetry measurement, histological staining, peripheral quantitative computed tomography (pQCT), cone-beam computed tomography (CBCT) and biomechanical load-to-failure tests. Both cement pastes displayed comparable results in mechanical strength and resorption kinetics. Bone-contact biocompatibility was excellent without any signs of inflammation. Initial resorption and bone remodeling could be observed. MPC pastes with IP 6 as setting retardant have the potential to be a valuable alternative in distinct fracture patterns. Drillability, promising resorption potential and high mechanical strength confirm their suitability for use in clinical routine.

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Section: Discussionmentioning

confidence: 99%

Degradation and Bone-Contact Biocompatibility of Two Drillable Magnesium Phosphate Bone Cements in an In Vivo Rabbit Bone Defect Model

Ewald,

Fuchs,

Boegelein

et al. 2023

Materials

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“…Phytic acid (inositol polyphosphate) was used as an innovative binding phase to prepare MPCs [ 147 , 161 , 162 , 163 ]: this molecule contains six phosphate groups, which could react with MgO-TMP, forming NEW as a cement binding phase. It was observed that the increase in phytic acid concentration resulted in an enhancement in the setting time of the cement from 11 to 16 min, representing a timeframe of interest in the bone cement field [ 147 ].…”

Section: Modifications Of Mpcsmentioning

confidence: 99%

An Overview of Magnesium-Phosphate-Based Cements as Bone Repair Materials

Gelli,

Ridi

2023

JFB

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In the search for effective biomaterials for bone repair, magnesium phosphate cements (MPCs) are nowadays gaining importance as bone void fillers thanks to their many attractive features that overcome some of the limitations of the well-investigated calcium-phosphate-based cements. The goal of this review was to highlight the main properties and applications of MPCs in the orthopedic field, focusing on the different types of formulations that have been described in the literature, their main features, and the in vivo and in vitro response towards them. The presented results will be useful to showcase the potential of MPCs in the orthopedic field and will suggest novel strategies to further boost their clinical application.

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“…[ 42 , 43 ] It has high bonding strength and can directly bond small fracture fragments. Heilig et al[ 44 ] found that MPC can effectively resist tensile loads and can significantly increase the pull-out strength of wire-based bone anchors. The evaluation results of cytotoxicity, skin sensitization, subcutaneous irritation and acute toxicity show that MPC is nontoxic, and toxicological experiments show that MPC does not cause deoxyribonucleic acid (DNA) damage and gene mutation, and it is safe.…”

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confidence: 99%

Application and modification of bone cement in vertebroplasty: A literature review

et al. 2022

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Vertebral compression fractures are more common in the elderly, particularly in postmenopausal women. Most of these people are accompanied by osteoporosis, which can easily lead to spinal deformities and fractures. Once a fracture occurs, the patient would have severe pain response, limited spinal movement, and need to stay in bed for a long time, resulting in a significant decrease in their quality of life. Percutaneous vertebroplasty (PVP) is a minimally invasive spinal surgery that injects bone cement into the diseased vertebrae for therapeutic purposes. It can quickly relieve pain and stabilize the spine. It is widely used in the treatment of vertebral compression fractures and is currently an ideal treatment method. There are many materials of bone cement used in clinical treatment, and each material has unique characteristics. Many scholars would modify the bone cement according to the advantages and disadvantages to make it more suitable for clinical use. In this review, we discuss the clinical application and modification of bone cement.

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Augmentation of suture anchors with magnesium phosphate cement – Simple technique with striking effect

Cited by 9 publications

References 44 publications

Degradation and Bone-Contact Biocompatibility of Two Drillable Magnesium Phosphate Bone Cements in an In Vivo Rabbit Bone Defect Model

Degradation and Bone-Contact Biocompatibility of Two Drillable Magnesium Phosphate Bone Cements in an In Vivo Rabbit Bone Defect Model

An Overview of Magnesium-Phosphate-Based Cements as Bone Repair Materials

Application and modification of bone cement in vertebroplasty: A literature review

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