Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)

Surwade, Priyanka; Ghildyal, Christopher; Weikel, Chase; Luxton, Todd P.; Peloquin, Derek M.; Fan, Xuetong; Shah, Vishal

doi:10.1038/s41429-018-0111-6

Cited by 46 publications

(25 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides AuNPs, other nanomaterials conjugated with AMPs such as AgNPs [ 259–267 ] and magnetic nanoparticles [ 268,269 ] were also reported on improving the antimicrobial activity. For instance, Yuan et al.…”

Section: Other Applications Of Peptide–gold Hybrid Nanomaterialsmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

View full text Add to dashboard Cite

Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide–AuNP‐based bio‐nano‐technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide–gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide–gold nanomaterials with functional properties are discussed along with future challenges and opportunities.

show abstract

Section: Other Applications Of Peptide–gold Hybrid Nanomaterialsmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Kontrol positif yang digunakan adalah ampisilin, yang merupakan antibiotik golongan penisilin I yang digunakan untuk mengatasi infeksi bakteri Gram positif dan Gram negatif. Hasil penelitian terdahulu menyebutkan bahwa ampisilin dapat menghambat pertumbuhan bakteri S. aureus dengan diameter zona bening sebesar 14 mm (Surwade et al, 2018). Menurut Nworu dan Esimone (2006), mekanisme kerja ampisilin adalah menghambat sintesis dinding sel bakteri dan enzim transpeptidase, sehingga tidak terjadi biosintesis sel.…”

Section: Aktivitas Antibakteriunclassified

IDENTIFIKASI SENYAWA AKTIF EKSTRAK DAUN CENGKEH (Syzygium aromaticum) SEBAGAI INHIBITOR Streptococcus mutans

Suhendar

Sogandi

2019

Al-Kauniyah J. Biol.

View full text Add to dashboard Cite

AbstrakKaries gigi adalah penyakit yang umum dialami oleh masyarakat yang terjadi karena buruknya kebersihan mulut. Kebiasaan masyarakat yang kurang menjaga kebersihan mulut mengakibatkan terbentuknya plak. Plak pada gigi terbentuk karena aktivitas dari berbagai macam mikroorganisme di mulut. Mikroorganisme yang diketahui terlibat dalam pembentukan karies gigi adalah Streptococcus mutans. Salah satu bahan alternatif sebagai antibakteri adalah daun cengkeh. Penelitian ini bertujuan untuk mengidentifikasi senyawa bioaktif daun cengkeh dan mengetahui mekanisme aksinya dalam menghambat pertumbuhan Streptococcus mutans. Daun cengkeh (Syzygium aromaticum) yang digunakan dalam penelitian ini dimaserasi menggunakan metanol 96%. Pengujian aktivitas antibakteri dilakukan dengan metode difusi agar, senyawa bioaktif diidentifikasi menggunakan gas chromatography mass spectrometry dan perubahan membran sel bakteri diamati dengan scanning electron microscopy. Hasil penelitian menunjukkan ekstrak metanol daun cengkeh memiliki aktivitas penghambatan terhadap pertumbuhan bakteri Streptococcus mutans dengan zona hambat sebesar ±32 mm serta nilai konsentrasi hambat minimum (KHM) 20% ekstrak. Mekanisme aksi penghambatan ekstrak daun cengkeh terhadap pertumbuhan bakteri diduga dengan membuat lubang pada membran sel bakteri. Hasil penelitian ini juga menunjukkan bahwa daun cengkeh memiliki kandungan senyawa bioaktif 3-allyl-6-methoxyphenol-eugenol, caryophyllene 1,4,7,-cycloundecatriene, 1,5,9,9-tetramethyl, phenol, 2-methoxy-4-(2-propenyl), dan eugenol acetate yang dapat menjadi kandidat penghasil senyawa aktif untuk mengatasi karies gigi.Abstract Dental caries is a common disease experienced by people who do not maintain oral hygiene. Habits of not maintain oral hygiene result in the formation of plaque. The microorganism known to be involved in the formation of dental caries is Streptococcus mutans. Plants that have antibacterial properties, such as clove (Syzygium aromaticum) leaf, can be an alternative for carrying this problem. This study aims to identify the bioactive compounds of clove leaves and to determine the mechanism of its action in inhibiting the growth of Streptococcus mutans. Clove leaves were macerated using 96% methanol for the extraction. Antibacterial activity was examined by agar diffusion method, bioactive compounds were identified using gas chromatography mass spectrometry, and bacterial cell membrane changes were observed by an image captured using scanning electron microscopy. The results showed that the methanol extract of clove leaf had inhibitory activity on Streptococcus mutans growth, with inhibitory zones of ±32 mm and the minimum inhibitory concentration (MIC) of 20% extract. It was suspected that the mechanism of inhibitory action is by making pores in the bacterial cell membrane. The results also showed that the clove leaves contain bioactive compounds of 3-allyl-6-methoxyphenol-eugenol, caryophyllene, 1,4,7, -cycloundecatriene, 1,5,9,9-tetramethyl, phenol, 2 -methoxy-4- (2-propenyl), and eugenol acetate which can be candidates for producing active compounds to overcome dental caries.

show abstract

“…Since the beginning of the 2000s, silver nanoparticles (Ag-NPs) have been used in various applications from pharmaceutics [ 1 , 2 , 3 , 4 ] to textiles [ 5 , 6 , 7 ] and from hygiene products [ 8 ] and packing materials [ 9 ] to daily food supplements [ 10 , 11 , 12 , 13 , 14 ]. Undoubtedly, Ag possesses unique antiseptic properties that have been known since antiquity [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain

Antsiferova

Kopaeva

Kochkin

et al. 2021

Toxics

View full text Add to dashboard Cite

The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.

show abstract

Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)

Cited by 46 publications

References 24 publications

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

IDENTIFIKASI SENYAWA AKTIF EKSTRAK DAUN CENGKEH (Syzygium aromaticum) SEBAGAI INHIBITOR Streptococcus mutans

Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain

Contact Info

Product

Resources

About