Augmented renal clearance and therapeutic monitoring of β-lactams

Udy, Andrew; Waele, Jan J. De; Lipman, Jeffrey

doi:10.1016/j.ijantimicag.2014.12.020

Cited by 27 publications

(19 citation statements)

References 33 publications

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“…Nowadays, the important issues remain regarding the diagnosis of ARC and the unclear impact of ARC on any clinical outcome (Udy et al 2012b). In this study, we have tried to adjust the dosage regimen for some patients, but the effects were not ideal.…”

Section: Discussionmentioning

confidence: 99%

Application of vancomycin in patients with varying renal function, especially those with augmented renal clearance

Chu

Luo

et al. 2016

Pharmaceutical Biology

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Context: Augmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute, and has attracted wide attention in recent years. Objective: This study evaluates the effects of ARC on serum vancomycin concentration in patients administered vancomycin. Materials and methods: This was a retrospective study in patients receiving vancomycin treatment at a dose of 1000 mg in every 12 h and undergoing serum monitoring admitted over a 2-year period (May 2013 to May 2015, in order to estimate the influence of ARC on serum vancomycin concentration. In this study, statistical comparisons were made on the results from patients grouped according to creatinine clearance (CL cr ). Results: One hundred forty-eight patients were enrolled in our study. The results showed that ARC patients were significantly younger, with a significantly lower S cr and higher GFR. The CL cr and steady-state trough concentrations of serum vancomycin exhibited a logarithmic correlation (Rs ¼ À0.699, R 2 ¼ 0.488, p < 0.01) in the patients included in our study. The trough vancomycin concentrations of 62.9% patients in high CL cr group were under 10 lg/mL. Discussion and conclusion: Since ARC was significantly associated with subtherapeutic serum vancomycin concentration, it was necessary to devise adjusted dosage regimens for these patients based on their CL cr .ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Application of vancomycin in patients with varying renal function, especially those with augmented renal clearance

Chu

Luo

et al. 2016

Pharmaceutical Biology

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“…However, in this relatively small heterogeneous cohort, there was no link between low trough concentrations and clinical failure. Further research is required in both the clinical implications of subthreshold concentrations and the ecological consequences for antibiotic resistance [18].…”

Section: Key Pointsmentioning

confidence: 99%

Optimizing dosing of antibiotics in critically ill patients

Parker

Sime

Roberts

2015

Current Opinion in Infectious Diseases

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“…Augmented antibiotic clearance has been identified in fit, healthy adult patients with sepsis, [36][37][38][39] and can be present in neonate and pediatric sepsis patients. However, establishing an adequate definition of a normal range that accounts for age-related variability and maturation in neonate and pediatric patients can be challenging, but should be determined before significant studies into augmented antibiotic clearance are undertaken.…”

Section: Altered Pharmacokinetics In Critically Ill Neonate and Pediamentioning

confidence: 99%

Uncertainty in Antibiotic Dosing in Critically Ill Neonate and Pediatric Patients: Can Microsampling Provide the Answers?

Dorofaeff

Bandini

Lipman

et al. 2016

Clinical Therapeutics

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Augmented renal clearance and therapeutic monitoring of β-lactams

Cited by 27 publications

References 33 publications

Application of vancomycin in patients with varying renal function, especially those with augmented renal clearance

Application of vancomycin in patients with varying renal function, especially those with augmented renal clearance

Optimizing dosing of antibiotics in critically ill patients

Uncertainty in Antibiotic Dosing in Critically Ill Neonate and Pediatric Patients: Can Microsampling Provide the Answers?

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