2014
DOI: 10.1016/j.jss.2014.05.026
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Augmenter of liver regeneration attenuates inflammatory response in the postischemic mouse liver in vivo

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Cited by 9 publications
(8 citation statements)
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“…In this regard, it is possible that hypothyroidism increases the expression of thyroid TRs α and β in the liver as has been observed in pancreatic islets [20], which could promote the hepatic proliferation [37]. This increment in the hepatocytes proliferation could counteract a possible ischemic liver injury [38].…”
Section: Discussionmentioning
confidence: 95%
“…In this regard, it is possible that hypothyroidism increases the expression of thyroid TRs α and β in the liver as has been observed in pancreatic islets [20], which could promote the hepatic proliferation [37]. This increment in the hepatocytes proliferation could counteract a possible ischemic liver injury [38].…”
Section: Discussionmentioning
confidence: 95%
“…Many studies have demonstrated the anti-apoptosis function of ALR in the liver. A recent study showed that exogenous administration of ALR attenuated the apoptotic, necrotic and inflammatory response to hepatocellular IRI in vivo [18]. In intraperitoneal hepatocyte transplantation rats, ALR can reduce pro-inflammatory cytokines, and apoptotic hepatocytes [19].…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with the experimental studies mentioned above, this effect is likely mediated by lowering the inflammatory response and reducing pro-inflammatory cytokine production [14,15]. Furthermore, recombinant human ALR has been shown to reduce IRI in rat kidneys [16] and livers [17], accompanied by lower serum transaminases, diminished apoptosis and less infiltration of inflammatory cells (neutrophils), but details on how rALR exerts this beneficial effect on hepatic IRI are still missing.…”
Section: Introductionmentioning
confidence: 60%