Aureobasidium pullulans infection: Fungemia in an infant and a review of human cases

Aureobasidium pullulans infection in a patient with chronic lymphocytic leukemia

“…Among the species of fungi belonging to Aureobasidium, A. pullulans is the species most commonly recognized as an etiologic agent of human disease 2,8 . Despite its limited pathogenicity, cutaneous and subcutaneous infections (i.e., phaeohyphomycoses and cromoblastomycoses), peritonitis in patients undergoing peritoneal dialysis, pulmonary mycosis, splenic and mandibular abscess, meningitis, eye infections (i.e., episcleritis and keratitis), tonsil infections, and disseminated infections have been described in the literature [1][2][3][4][5][6][8][9][10][11] . Several conditions can predispose patients to infection by fungal saprophytes, including immunosuppression, which can be due to cancer chemotherapy or organ transplantation, the broad and extensive spectrum of antimicrobial therapy, and the disruption of natural barriers, which occurs during major surgery or trauma 2,5,12 .…”

“…Multiple samples isolated from normally sterile sites that exhibit tissue invasion and signs of infection are critical for these diagnoses because growth in blood cultures is uncommon 2,3,9 . The macroscopic aspect and microscopic analysis of colonies, in combination with molecular techniques, are methods for the identifi cation of the fungus responsible for the infection 12 .…”

“…Its pathogenic ability in humans is becoming recognized, especially in situations of immunosuppression. However, its pathogenic mechanism remains unknown [2][3][4][5][6] .…”

Chronic fungal meningitis caused by Aureobasidium proteae

“…Aureobasidium species are molds known to cause fungemia, eye and skin infections (Hawkes et al, 2005). The only member of the species reported to cause meningitis is Aureobasidium mansoni (Krcméry et al, 1994;Huttova et al, 1998) We present a case of chronic meningitis caused by Aureobasidium protae.…”

Mycotoxin Decontamination Aspects in Food, Feed and Renewables Using Fermentation Processes

“…The use as a biocontrol agent was also assessed as a reduction of OTA in grapes and wine was reported. However, the fungus appears to be involved in human disease and this issue needs to be resolved before more general use can be recommended [101].…”