Auricular Keloids

Bran, Gregor; Brom, Jörn; Hörmann, K.; Stuck, Boris A.

doi:10.1001/archfaci.2011.57

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Current treatment approaches include topical anti-scarring application, surgical excision, cryotherapy, pressure dressing, laser therapy, intralesional corticosteroid injections, and antimetabolites. [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] The aim of this review is to briefly describe cutaneous wound healing processes and the participating immune cells, then provide a comprehensive overview of the immune and associated molecular targets involved in raised dermal scarring conditions.…”

Section: Introductionmentioning

confidence: 99%

“…The high recurrence rate that often occurs post‐conventional therapies is a clinical challege and a major cause to intensify research for identifying better therapies with minimal side effects and reduced recurrence rates. Current treatment approaches include topical anti‐scarring application, surgical excision, cryotherapy, pressure dressing, laser therapy, intralesional corticosteroid injections, and antimetabolites 32–48 …”

Section: Introductionmentioning

confidence: 99%

“…Current treatment approaches include topical anti‐scarring application, surgical excision, cryotherapy, pressure dressing, laser therapy, intralesional corticosteroid injections, and antimetabolites. 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 …”

Section: Introductionmentioning

confidence: 99%

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Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars

Kidzeru

Lebeko

Sharma

et al. 2023

Experimental Dermatology

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Raised dermal scars including hypertrophic, and keloid scars as well as scalp‐associated fibrosing Folliculitis Keloidalis Nuchae (FKN) are a group of fibrotic raised dermal lesions that mostly occur following cutaneous injury. They are characterized by increased extracellular matrix (ECM) deposition, primarily excessive collagen type 1 production by hyperproliferative fibroblasts. The extent of ECM deposition is thought to be proportional to the severity of local skin inflammation leading to excessive fibrosis of the dermis. Due to a lack of suitable study models, therapy for raised dermal scars remains ill‐defined. Immune cells and their associated markers have been strongly associated with dermal fibrosis. Therefore, modulation of the immune system and use of anti‐inflammatory cytokines are of potential interest in the management of dermal fibrosis. In this review, we will discuss the importance of immune factors in the pathogenesis of raised dermal scarring. The aim here is to provide an up‐to‐date comprehensive review of the literature, from PubMed, Scopus, and other relevant search engines in order to describe the known immunological factors associated with raised dermal scarring. The importance of immune cells including mast cells, macrophages, lymphocytes, and relevant molecules such as cytokines, chemokines, and growth factors, antibodies, transcription factors, and other immune‐associated molecules as well as tissue lymphoid aggregates identified within raised dermal scars will be presented. A growing body of evidence points to a shift from proinflammatory Th1 response to regulatory/anti‐inflammatory Th2 response being associated with the development of fibrogenesis in raised dermal scarring. In summary, a better understanding of immune cells and associated molecular markers in dermal fibrosis will likely enable future development of potential immune‐modulated therapeutic, diagnostic, and theranostic targets in raised dermal scarring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars

Kidzeru

Lebeko

Sharma

et al. 2023

Experimental Dermatology

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“…Using a variety of different auricular pressure devices, auricular keloid response rates of 90% to 100% are reported in the literature. 6,8,[13][14][15][16] The success of pressure therapy as an adjuvant to surgery and steroid injections relies on high-precise pressure adjustments and patient compliance. Patient compliance requires a light, strong, aesthetically acceptable and comfortable device that even for the youngest patients is easy to attach to the auricle.…”

Section: Discussionmentioning

confidence: 99%

“…Our treatment protocol is adapted from Bran and colleagues 6 , and it combined intramarginal auricular keloid resection under magnification, with a sequence of 40 mg/ mL triamcinolone acetonide injections and a custom-made acrylate pressure device (Figure 1). Keloids were removed and debulked with an intralesional, bevelled excision under magnification.…”

Section: Triple Therapy Protocolmentioning

confidence: 99%

Triple Therapy Protocol for Primary and Secondary Auricular Keloids: A Prospective Outcome Evaluation

et al. 2023

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BACKGROUND Ear keloid lesions present a significant challenge to the aesthetic surgeon. Keloids are known to recur and can cause severe cosmetic, functional, and psychological impairments. Several adjuvants to surgical removal have been promoted, with varying recurrence rates. OBJECTIVE To evaluate the effectiveness of triple therapy to treat secondary (and large primary) auricular keloids. MATERIALS AND METHODS Patients with secondary or large primary auricular keloids undergoing triple therapy were prospectively studied. Keloids were excised intramarginally under magnification and repeated triamcinolone acetonide 40 mg/mL injections were administered, followed by the application of a custom-made acrylate pressure device. Recurrent keloid formation and adverse events were monitored during a minimum of 6 months of follow-up. RESULTS Sixteen auricular keloid lesions (3 large primary and 13 secondary) were subjected to the proposed technique with a mean follow-up of 28 months. All cases that adhered to the protocol were free of keloid after triple therapy. Side effects were limited to 1 case of lobular atrophy and slight hypopigmentation. All patients were satisfied with the results. CONCLUSION The triple therapy protocol is highly effective in primary and secondary auricular keloid as long as patients remain compliant.

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Clinical Outcome and Quality of Life After a Multimodal Therapy Approach to Ear Keloids

Walliczek

Engel

Weiß

et al. 2015

JAMA Facial Plast Surg

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IMPORTANCE Keloids are fibroproliferative scars that can cause a huge psychological burden and severe problems for patients, such as depression. Many treatment options exist; however, recurrence rates, especially with monotherapy, remain high.OBJECTIVE To investigate the recurrence rate and changes in quality of life after multimodal therapy. DESIGN, SETTING, AND PARTICIPANTSA total of 33 patients with 42 auricle keloids (24 female and 9 male patients; mean [SD] age, 27 [17] years) were enrolled in a prospective cohort study and underwent intramarginal keloid excision and multimodal therapy. Patients were observed postoperatively in the outpatient

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Auricular Keloids

Cited by 12 publications

References 15 publications

Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars

Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars

Triple Therapy Protocol for Primary and Secondary Auricular Keloids: A Prospective Outcome Evaluation

Clinical Outcome and Quality of Life After a Multimodal Therapy Approach to Ear Keloids

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