Auspicious water treatment approach. Oxidative degradation of fluconazole and voriconazole antibiotics by CrO3 in different acidic environments: Kinetics, mechanistic and thermodynamic modelling

Fawzy, Ahmed; Alqarni, Nada; El-Gammal, B.; Toghan, Arafat; Hassan, Nasser A.; Algarni, Zaina

doi:10.1016/j.jscs.2021.101396

Cited by 9 publications

(9 citation statements)

References 49 publications

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“…Pharmaceuticals are emerging environmental contaminants, which are extensively used for human and veterinary medicine [ 1 ]. Antibiotics represents about 70% of all the consumed pharmaceuticals that are used for human and animal medicines, usually as a therapy or curative to enhance life expectancy.…”

Section: Introductionmentioning

confidence: 99%

“…The rest (active substances) are ejected from the body (in the urine and feces) into the environment and wastewater treatment plants without complete metabolization. Thus, the wastewater treatment plants and hospitals, amongst others, are the main sources through which these contaminants are released into the environment [ 1 ]. Due to the hydrophobicity and lipophilic nature of ABs and their residues, their elimination from wastewater becomes difficult.…”

Section: Introductionmentioning

confidence: 99%

“…The appearance of antibiotics in the environment has been linked to an increase in the number of resistant bacteria. The rapid growth of drug-resistant infections is alarming, it is estimated that by 2050 this will lead to 70,000 deaths per year [ 1 , 3 ]. This has economic consequences, therefore, proactive actions including engineered technology and waste management should be improved [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Studies on antibiotics have drawn much attention due to the high detection frequency of antibiotics in the environment [ 1 , 3 , 4 , 5 ]. The detection of antibiotics in the environment is found to be in the range of ng/L and µg/L, and even mg/L [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology

et al. 2022

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The inappropriate use and indiscriminate disposal of antibiotics has become a menace worldwide. The incomplete removal of these contaminants from wastewater treatment plants has also contributed to this. This study presents the biodegradation of two veterinary antibiotics; ciprofloxacin (CIP) and enrofloxacin (ENRO). Kinetics models were explored to understand the dynamics of biodegradation in an anaerobic digestion process. This was carried out in batch reactors under various operating conditions: pH, organic loading rate (OLR), and antibiotic concentration. The influence of the parameters was investigated using a response surface methodology (RSM) based on the Box–Behnken experimental design of 15 runs. The data obtained were fitted on a polynomial function model. OLR and pH exhibited a synergistic and antagonistic effect in the response models developed, with a high correlation regression coefficient (R2; 0.9834–0.9875) close to 1 at a 95% confidence level. The optimum conditions obtained from the RSM numerical optimization were pH (6), OLR (2 kgCOD·m−3·days−1), and an antibiotic concentration of 75%, which gave the removal of CIP, ENRO, and COD, respectively, as 80%, 83%, and 73% at a desirability function of 85%. The kinetics study shows that the biodegradation of antibiotics was well fitted on a first-order model (R2; 0.9885–0.9978) with rate constants ranging from 0.0695 to 0.96 days−1.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology

et al. 2022

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“…Nonetheless, we can also find it in household products such as soap, shampoo, dermal creams, shower gels, and toothpaste [2] . In addition, FCZ is widely used as fungicide in agriculture and biocide in a variety of products [3] . FCZ enters the ecosystems from human and animal excreta after its metabolization, wastewater treatment plants, wastes coming from pharmaceutical industries, medical centers, households, and hospitals [4] .…”

Section: Introductionmentioning

confidence: 99%

Environmentally relevant concentrations of fluconazole alter the embryonic development, oxidative status, and gene expression of NRF1, NRF2, WNT3A, WNT8A, NRD1, and NRD2 of Danio rerio embryos

Escobar-Huerfano¹,

Elizalde-Velázquez²,

Gómez-Oliván³

et al. 2022

WECN

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Up to date, there is little information published concerning fluconazole (FCZ) toxicity at environmentally relevant concentrations. Bearing in mind the above background of FCZ, we aimed to evaluate the embryotoxic effects environmentally relevant concentrations of FCZ (800-1000 ng/L) may induce in Danio rerio. Moreover, we also wanted to prove whether these FCZ concentrations could generate oxidative stress and alter the expression of several genes related to the antioxidant mechanisms, sterol and retinol biosynthesis, and embryogenesis. Our findings demonstrate that FCZ, at all concentrations, induced pericardial edema, yolk sac deformation, scoliosis, and tail malformation in embryos. Moreover, we also demonstrated this drug altered the redox equilibrium of fish, promoting the production of lipoperoxidation level, hydroperoxide content, and protein carbonyl content in a concentration-dependent manner. Concerning gene expression, FCZ downregulated wingless-type MMTV integration site family member 3a (WNT3A), wingless-type MMTV integration site family member 8a (WNT8A), N-arginine dibasic convertase 1 (NRD1), and N-arginine dibasic convertase 2 (NRD2) and upregulated cytochrome P450 family 26 subfamily a member 1 (CYP26A1), cytochrome P450 family 26 subfamily a member 1B (CYP261B), nuclear respiratory factor 1 (NRF1), and nuclear respiratory factor 2 (NRF2) in D. rerio larvae. Collectively, our results point out that FCZ, at low concentrations, may alter the embryogenesis, oxidative status, and expression of several genes in D. rerio embryos via an impairment in sterol and retinol biosynthesis. Thus, our results provide some of the first evidence that FCZ, even at environmentally relevant concentrations, is harmful to aquatic species.

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Scalable fabrication and characterization of Y2O3@g-C3N4 nanocomposite for the enhancement of photocatalytic removal of Congo red dye under visible light

Modwi

Mustafa

Toghan

et al. 2023

J Mater Sci: Mater Electron

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Auspicious water treatment approach. Oxidative degradation of fluconazole and voriconazole antibiotics by CrO3 in different acidic environments: Kinetics, mechanistic and thermodynamic modelling

Cited by 9 publications

References 49 publications

Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology

Evaluating the Biodegradation of Veterinary Antibiotics Using Kinetics Model and Response Surface Methodology

Environmentally relevant concentrations of fluconazole alter the embryonic development, oxidative status, and gene expression of NRF1, NRF2, WNT3A, WNT8A, NRD1, and NRD2 of Danio rerio embryos

Scalable fabrication and characterization of Y2O3@g-C3N4 nanocomposite for the enhancement of photocatalytic removal of Congo red dye under visible light

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