Autacoids in sputum in cases of bronchial asthma and other respiratory diseases

Histamine in Nasal Secretions

“…Histamine con centrations in nasal mucous in the present study are similar to reported levels in nasal tissue (15.7 ng/g wet weight) [1,2], and blood (19-57.6 ng/ml) [2,23,26], but is higher than that in sputum (0.1-0.49 ng/g wet weight) [24] and plasma or serum (0-2 ng/ml) [2][3][4], Our findings are also in keeping with earlier observations that asymptomatic allergic subjects and normals have similar histamine concentrations in blood [2,17], urine [8,17,19] and nasal tissue [1], Our findings that histamine concentra tions were 4 times higher in nasal secretions from male subjects than from females was unexpected, and is difficult to explain. The histamine content of mucous mem brane [1], blood [9], or urine [5,18] of males is not greater than females.…”

“…Respiratory secretions have been poorly studied. One brief report describes increased concentrations in sputum from symptomatic asthmatics [24]. Nasal secretions have not been studied at all.…”