Histamine in Nasal Secretions

Pa, Eggleston; Hendley, J. Owen; Jm, Gwaltney; Aw, Eggleston; Bs, Leavell

doi:10.1159/000232103

Cited by 36 publications

(10 citation statements)

References 16 publications

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“…Prior to provocation, five lavages were performed at 4-rain intervals. As previously observed by us (Miadonna et al 1987) and others (Eggleston et al 1978), high histamine levels can be detected in the first nasal lavages from some symptomfree subjects who have not been exposed to allergens. Therefore, five preliminary lavages were performed to obtain low and uniform prechallenge mediator levels.…”

Section: Nasal Stimulation Nasal Lavage Procedures and Symptom Registsupporting

confidence: 79%

Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106)

Miadonna

Cottini

Candiani

et al. 1994

Eur J Clin Pharmacol

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The aim of this study was to evaluate the effects of the new anti-allergic drug, N-acetyl-aspartyl-glutamate (ZY15106), on allergen-induced nasal symptoms and mediator release. Fifteen outpatients suffering from seasonal allergic rhinitis due to grass pollen were included in the study. A nasal antigen challenge followed by evaluation of symptoms was performed in basal conditions. Ten of the 15 patients underwent sequential nasal lavages in order to evaluate allergen-induced mediator release. The study was performed in winter, when the patients were symptom free, and was a randomized single-blind crossover trial of a 6% solution of ZY15106 (daily dosage: 48 mg) versus placebo (lactose). The drug and the placebo were administered intranasally q.i.d. for 1 week, with a 2-week interval between the two treatments. Treatment with ZY15106, but not with placebo, caused a significant reduction in nasal obstruction in the first 30 min after challenge and at 60 min and itching in the first 10 min after challenge, but did not reduce sneezing and rhinorrhoea. Moreover, ZY15106 significantly reduced the histamine release in 5 min postchallenge lavage (4.5 ng.ml-1 after placebo administration vs 2.5 ng.ml-1, after treatment with ZY15106). A reduction in immunoreactive LTC4 release in the 5 and 10 min post-challenge lavages was observed after ZY15106 administration (placebo vs active treatment: at 5 min 2.9 ng.ml-1 vs 1.4 ng.ml-1; at 10 min: 2.25 ng.ml-1 vs 0.9 ng.ml-1).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Nasal Stimulation Nasal Lavage Procedures and Symptom Registsupporting

confidence: 79%

Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106)

Miadonna

Cottini

Candiani

et al. 1994

Eur J Clin Pharmacol

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“…Eggleston et al [1978] found histamine concentrations in nasal secre tions ranging from 0 to 1,419 ng/ml (mean 91 ng/ml), and were also able to show that the concentration of histamine varies widely from day to day in the same subject, and that essentially there was no difference between normal and atopic individuals. Thus it ap pears that normal nasal mucosa produces some free histamine.…”

Section: Discussionmentioning

confidence: 77%

Clinical Symptoms, Free Histamine and IgE in Patients with Nasal Polyposis

Drake-Lee

Mclaughlan

1982

Int Arch Allergy Immunol

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29 adult patients with nasal polyps were studied. The clinical symptoms and atopic profile were compared with both the level of histamine and IgE found in polyp fluid. The high concentration of free histamine found in polyp fluid was probably pathological, and local IgE was present in greater amounts than expected by simple diffusion. There was no evidence that clinical hypersensitivity is associated with higher concentrations of IgE and histamine in polyp fluid; it is possible that mechanisms other than an IgE-mediated response could cause degranulation of mast cells in nasal polyps.

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“…The rationale for several baseline lavages is to decrease the levels of mediators before challenge in order to detect the changes in mediator concentrations induced by the challenge more efficiently. It is well known that there is a significant concentration of histamine in the nose at rest, even in healthy subjects [37]. However, we were interested in other substances, such as substance P and tryptase, the concentrations of which are known to be low in nasal lavage fluid [10,38].…”

Section: Discussionmentioning

confidence: 99%