Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106)

Abstract

The aim of this study was to evaluate the effects of the new anti-allergic drug, N-acetyl-aspartyl-glutamate (ZY15106), on allergen-induced nasal symptoms and mediator release. Fifteen outpatients suffering from seasonal allergic rhinitis due to grass pollen were included in the study. A nasal antigen challenge followed by evaluation of symptoms was performed in basal conditions. Ten of the 15 patients underwent sequential nasal lavages in order to evaluate allergen-induced mediator release. The study was performed in winter, when the patients were symptom free, and was a randomized single-blind crossover trial of a 6% solution of ZY15106 (daily dosage: 48 mg) versus placebo (lactose). The drug and the placebo were administered intranasally q.i.d. for 1 week, with a 2-week interval between the two treatments. Treatment with ZY15106, but not with placebo, caused a significant reduction in nasal obstruction in the first 30 min after challenge and at 60 min and itching in the first 10 min after challenge, but did not reduce sneezing and rhinorrhoea. Moreover, ZY15106 significantly reduced the histamine release in 5 min postchallenge lavage (4.5 ng.ml-1 after placebo administration vs 2.5 ng.ml-1, after treatment with ZY15106). A reduction in immunoreactive LTC4 release in the 5 and 10 min post-challenge lavages was observed after ZY15106 administration (placebo vs active treatment: at 5 min 2.9 ng.ml-1 vs 1.4 ng.ml-1; at 10 min: 2.25 ng.ml-1 vs 0.9 ng.ml-1).(ABSTRACT TRUNCATED AT 250 WORDS)

Treatment of common ocular allergic disorders; a comparison of lodoxamide and NAAGA

“…Previous publications have reported superiority of topical lodoxamide over cromolyn sodium in the treatment of allergic conjunctivitis7 and comparable efficacy of NAAGA and cromolyn sodium in this disease 14. The results of the present study confirmed the efficacy of lodoxamide and NAAGA.…”

“…NAAGA is a naturally occurring dipeptide in mammalian brain 11. A mast cell degranulation inhibitor, which also inhibits complement activation and leukotriene release,12 it had been shown to be similar in efficacy to cromolyn sodium in the symptomatic treatment of seasonal allergic rhinitis13 and to modulate allergen induced nasal symptoms and mediator release 14. Although it has been reported to be ineffective in giant papillary conjunctivitis,15 a study in allergic conjunctivitis showed it be as effective as cromolyn sodium 16…”