Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies

Jena, Atala Bihari; Kanungo, Namrata; Nayak, Vinayak; Chainy, G.B.N.; Dandapat, Jagneshwar

doi:10.1038/s41598-021-88218-3

Cited by 10 publications

(3 citation statements)

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“…A molecular docking study of 18 plant constituents to SARS-CoV-2 proteins showed that EGCG bound with higher affinity than the antiviral drugs chloroquine and remdesivir to all tested SARS-CoV-2 protein targets, including Mpro, S protein, S2 subunit of the S protein, RBD-ACE2 complex and NSP15 endoribonuclease [ 67 ]. The previous study was in agreement with another molecular docking study which showed high binding affinity of EGCG and catechin to SARS-CoV-2 proteins such as Mpro, RNA-dependent RNA polymerase, PLpro, RBD of S protein, NSP6, N protein, ACE2 receptor and ACE2 receptor bound to RBD [ 68 , 69 , 70 , 71 ]. The binding of EGCG to SARS-CoV-2-S protein was further confirmed by a molecular docking study which showed high-affinity binding to S protein [ 72 ], and another study which showed high-affinity binding not only to the S protein of the wild-type strain but to the UK mutant strain S protein [ 73 ].…”

Section: Anti-sars-cov-2 Activity Of Catechinssupporting

confidence: 89%

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury

Diniz¹,

Elshabrawy

Souza

et al. 2021

Molecules

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Data obtained from several intensive care units around the world have provided substantial evidence of the strong association between impairment of the renal function and in-hospital deaths of critically ill COVID-19 patients, especially those with comorbidities and requiring renal replacement therapy (RRT). Acute kidney injury (AKI) is a common renal disorder of various etiologies characterized by a sudden and sustained decrease of renal function. Studies have shown that 5–46% of COVID-19 patients develop AKI during hospital stay, and the mortality of those patients may reach up to 100% depending on various factors, such as organ failures and RRT requirement. Catechins are natural products that have multiple pharmacological activities, including anti-coronavirus and reno-protective activities against kidney injury induced by nephrotoxic agents, obstructive nephropathies and AKI accompanying metabolic and cardiovascular disorders. Therefore, in this review, we discuss the anti-SARS-CoV-2 and reno-protective effects of catechins from a mechanistic perspective. We believe that catechins may serve as promising therapeutics in COVID-19-associated AKI due to their well-recognized anti-SARS-CoV-2, and antioxidant and anti-inflammatory properties that mediate their reno-protective activities.

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Section: Anti-sars-cov-2 Activity Of Catechinssupporting

confidence: 89%

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury

Diniz¹,

Elshabrawy

Souza

et al. 2021

Molecules

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“…Curcumin derived from the rhizome of turmeric (Curcuma longa) has high binding affinity for SARS-CoV-2 spike protein, host cell ACE2 receptor, and RBD/ACE2 complex [99], suggesting that curcumin may inhibit the cellular entry of SARS-CoV-2. Curcumin also shows virucidal effects independently of SARS-CoV-2 variants and inhibitory effects on the release of pro-inflammatory cytokine IL-1b, IL-6, and IL-8 [100].…”

Section: Treatment With Curcumin and Outcomementioning

confidence: 99%

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Tsuchiya¹

2023

Preprint

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Since the worldwide spread of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), treating taste and saliva secretory disorders associated with coronavirus disease 2019 (COVID-19) has become one of the most critical issues in the COVID-19 era. The aim of the present study was to update information on treatments being applicable to such oral symptoms and discuss their pathogenic mechanisms. Promising treatments include different types of methods using tetracycline, corticosteroid, zinc, stellate ganglion block, phytochemical curcumin, traditional herbal medicine, nutraceutical vitamin D, photobiomodulation, antiviral drug, malic acid sialagogue, chewing gum, acupuncture, and/or moxibustion. At present, however, fully validated treatments are still lacking for COVID-19-associated ageusia/dysgeusia/hypogeusia and xerostomia/dry mouth/hyposalivation. An appropriately selected treatment and oral healthcare should be provided to COVID-19 patients and survivors suffering from taste and saliva secretory disorders. Understanding of currently available treatment options is required for dental profes-sionals because they not only experience patients who were infected with SARS-CoV-2 or recov-ered from COVID-19 but first become aware of their abnormal taste and salivary secretion. By doing so, dentists and dental hygienists can play a crucial role in managing COVID-19-associated oral symptoms and contribute to improving the oral health-related quality of life of the relevant dental patients.

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“…Human pathogenic coronavirus, including severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, it binds to the angiotensinogen-converting enzyme 2 (ACE2), a recently discovered mono-carboxypeptidase and the first ACE homolog, and then enters the cell ( 1 ). SARS-CoV S1 contains a receptor-binding domain (RBD) that explicitly recognizes ACE2 as its receptor ( 2 ), and tea polyphenols (TPs) have been found to bind to RBD to inhibit virus invasion ( 3 ). Numerous studies have demonstrated TPs to prevent obesity, diabetes, cardiovascular disease, cancer, and antiviral activity and fight diseases caused by oxidative stress and inflammation ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Potential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung Axis

Liu

et al. 2022

Front. Nutr.

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Coronavirus disease 2019 (COVID-19) disrupts the intestinal micro-ecological balance, and patients often develop the intestinal disease. The gut is the largest immune organ in the human body; intestinal microbes can affect the immune function of the lungs through the gut-lung axis. It has been reported that tea polyphenols (TPs) have antiviral and prebiotic activity. In this review, we discussed TPs reduced lung-related diseases through gut-lung axis by inhibiting dysbiosis. In addition, we also highlighted the preventive and therapeutic effects of TPs on COVID-19 complications, further demonstrating the importance of research on TPs for the prevention and treatment of COVID-19 in humans. Based on this understanding, we recommend using TPs to regulate the gut microbiota to prevent or alleviate COVID-19 through the gut-lung axis.

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Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 10 publications

References 0 publications

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Potential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung Axis

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