Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Abstract

In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been added to the list, and the author contributions section has been updated to include Alexander J. Lazar's contribution to the study. The error has been corrected in the print, PDF and HTML versions of the manuscript.

Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients

“…Endoscopic evaluation showed marked improvement, indicated by a reduction in CD+ T cells and concomitant increase in CD4+ FOXp3+.Patient 2: Partial improvement with persistent ulcers and recurrent abdominal pain. Complete resolution after second FMT.In both patients, the number of OTUs increased following FMT, with principal coordinates analyses of unweighted UniFrac distances demonstrating the microbiome composition was similar to those of the donor.Wang et al [45]InfectionRetrospective clinical study; N = 10Data was retrospectively analysed from consecutive adult patients diagnosed with hematological malignancy who received FMT during allo-SCT for multi-drug resistant bacteria colonization.All patients were on immunosuppressive medication.Healthy related or unrelated donors aged between 18 and 65 with no digestive disorders within 3 months of donation, no chronic disease or treatments, no antibiotics in the past 3 months. Donors were also excluded if they lived in the tropics, or had been hospitalised abroad for >24 h in the year leading up to donation.…”

“…Additionally, modulation of the gut microbiota via FMT from patients has been shown to alter antitumor immunity and response to immunotherapy in gnotobiotic mice (Table 2) [44]. These findings have now prompted investigation of FMT as a therapeutic option for refractory immunotherapy-induced colitis [45].…”

“…In 2018, the first case series of immune checkpoint inhibitor-associated colitis successfully treated with FMT was published [45]. Data, from the treatment of two individuals, highlight the ability of donor FMT (50 g, delivered by colonoscopy) to restore microbial diversity and induce complete resolution of clinical symptoms.…”

Case Report: Anti-TNF Treatment Failure in a Patient With Immune Checkpoint Inhibitor-Induced Severe Colitis

“…In this instance, for patients with IBD, tofacitinib, ustekinumab, and calcineurin inhibitors could be appropriate remedial measures, but their safety and efficacy are unclear for patients with ICI-related colitis. In addition, fecal microbiota transplant (FMT) has recently been used for ICI-related colitis, and data from a case series of two patients treated with FMT appear encouraging ( 25 ). However, it is very early work, and more data are required in this area before this can be recommended.…”

“…Recent evidence reported a low density of Foxp3 + CD4 + T cells (Treg) in the inflamed colonic mucosa of patients with ICI-associated colitis. Following treatment, there was a substantial increase in Foxp3 + CD4 + T cells in these patients ( 14 ). Thus, T-cell subtypes like Foxp3 + CD4 + T cells and related cytokines like IL-17A and TNF may be potential prognostic factors for ICI-associated colitis.…”