Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia

Iaccarino, Hannah F.; Singer, Annabelle C.; Martorell, Anthony J; Rudenko, Andrii; Gillingham, Tyler Z.; Mathys, Hansruedi; Seo, Jinsoo; Kritskiy, Oleg; Abdurrob, Fatema; Adaikkan, Chinnakkaruppan; Canter, Rebecca G.; Rueda, Richard; Brown, Emery N.; Boyden, Edward S.; Tsai, Li‐Huei

doi:10.1038/s41586-018-0351-4

Cited by 22 publications

(12 citation statements)

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“…Inclusively, this work shows that beta and alpha neural oscillations can be phase aligned using musical rhythms ( Fujioka et al, 2009 , 2012 , 2015 ; Comstock et al, 2021 ; Ross et al, 2022 ), which is consistent with the literature on sensory phase entrainment more broadly ( Snyder and Large, 2005 ; Cardin et al, 2009 ; Arnal and Giraud, 2012 ; Santarnecchi et al, 2016 ; Iaccarino et al, 2018 ; Comstock et al, 2021 ; National Library of Medicine., 2021a , b ; Ross et al, 2022 ). This growing literature shows that musical rhythms reliably induce phase synchronization ( Snyder and Large, 2005 ; Fujioka et al, 2009 , 2012 , 2015 ; Iversen et al, 2009 ; Saleh et al, 2010 ; Varlet et al, 2020 ; Comstock et al, 2021 ; Ross et al, 2022 ) that is tempo dependent ( Fujioka et al, 2012 ), can be caused by either heard or imagined stimuli ( Snyder and Large, 2005 ; Iversen et al, 2009 ), and modulates network coherence ( Fujioka et al, 2012 ).…”

Section: Sensorimotor Engagement When There Is No Motor Tasksupporting

confidence: 90%

“…This perspective of time perception has numerous implications for topics of development, brain health, and motor rehabilitation. Atypical oscillatory activity is associated with cognitive deficits ( Cardin et al, 2009 ; Santarnecchi et al, 2016 ) and disease ( Koenig et al, 2005 ; Iaccarino et al, 2018 ; Benwell et al, 2020 ), including in fluid intelligence ( Santarnecchi et al, 2016 ) and attention ( Cardin et al, 2009 ), type 2 diabetes ( Benwell et al, 2020 ), mild cognitive impairment ( Koenig et al, 2005 ), and Alzheimer’s disease ( Koenig et al, 2005 ; Iaccarino et al, 2018 ; Benwell et al, 2020 ). Modulation of these atypical oscillations is being explored for therapeutic effects using optogenetics ( Cardin et al, 2009 ), tACS ( Santarnecchi et al, 2016 ), and sensory stimuli in the gamma band ( Cardin et al, 2009 ; National Library of Medicine., 2021a , b ).…”

Section: Discussionmentioning

confidence: 99%

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Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction

Ross

Balasubramaniam

2022

Front. Integr. Neurosci.

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Neural mechanisms supporting time perception in continuously changing sensory environments may be relevant to a broader understanding of how the human brain utilizes time in cognition and action. In this review, we describe current theories of sensorimotor engagement in the support of subsecond timing. We focus on musical timing due to the extensive literature surrounding movement with and perception of musical rhythms. First, we define commonly used but ambiguous concepts including neural entrainment, simulation, and prediction in the context of musical timing. Next, we summarize the literature on sensorimotor timing during perception and performance and describe current theories of sensorimotor engagement in the support of subsecond timing. We review the evidence supporting that sensorimotor engagement is critical in accurate time perception. Finally, potential clinical implications for a sensorimotor perspective of timing are highlighted.

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Section: Sensorimotor Engagement When There Is No Motor Tasksupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction

Ross

Balasubramaniam

2022

Front. Integr. Neurosci.

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“…In conclusion, the still new and evolving field of 2-P all-optical physiology opens up tremendous prospects, also in the field of preclinical research aiming for network-based therapies [19,36], but, we suggest a careful and holistic approach including a pipeline for further exploratory research as devised here in order to maximize translational power. Fig.…”

Section: Discussionmentioning

confidence: 92%

Navigating the translational roadblock: Towards highly specific and effective all-optical interrogations of neural circuits

Arnoux

Doering

et al. 2020

Preprint

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contributing first authors One Sentence Summary: We maximize translational relevance of 2-P all-optical physiology by increasing specificity, minimizing artifacts and optimizing stimulation efficacy. Abstract:Two-photon (2-P) all-optical approaches combine in vivo 2-P calcium imaging and 2-P optogenetic modulations and have the potential to build a framework for network-based therapies, e.g. for rebalancing maladaptive activity patterns in preclinical models of neurological disorders. Here, our goal was to tailor these approaches for this purpose: Firstly, we combined in vivo juxtacellular recordings and GCaMP6f-based 2-P calcium imaging in layer II/III of mouse visual cortex to tune our detection algorithm towards a 100 % specific identification of APrelated calcium transients. False-positive-free detection was achieved at a sensitivity of approximately 73 %. To further increase specificity, secondly, we minimized photostimulation artifacts as a potential source for false-positives by using extended-wavelength-spectrum laser sources for optogenetic stimulation of the excitatory opsin C1V1. We achieved artifact-free all-optical experiments performing photostimulations at 1100 nm or higher and simultaneous calcium imaging at 920 nm in mouse visual cortex in vivo. Thirdly, we determined the spectral range for maximizing efficacy of optogenetic control by performing 2-P photostimulations of individual neurons with wavelengths up to 1300 nm. The rate of evoked transients in GCaMP6f/C1V1-coexpressing cortical neurons peaked already at 1100 nm. By refining spike detection and defining 1100 nm as the optimal wavelength for artifact-free and effective stimulations of C1V1 in GCaMP-based all-optical interrogations, we increased the translational value of these approaches, e.g. for the use in preclinical applications of network-based therapies.

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“…The likelihood of exacerbating tau hyper-phosphorylation [217, 218], as well as disrupting bacterial clearance by peripheral immune system with systemic suppression of CX3CR1 signaling [219], suggest the importance of searching for approaches to target CX3CR1 signaling specifically in plaque-associated microglia and to minimize potential systemic side effects [220]. Intriguingly, recent reports described that LED-based light flicker stimuli at 40 Hz could promote microglial recruitment, thereby reducing brain amyloid levels in AD transgenic mouse models [221–223].…”

Section: Mechanism-based Approachesmentioning

confidence: 99%

Advances in developing novel therapeutic strategies for Alzheimer’s disease

Cao

Hou

Jing

et al. 2018

Mol Neurodegeneration

217

142

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Alzheimer’s Disease (AD), the most prevalent neurodegenerative disease of aging, affects one in eight older Americans. Nearly all drug treatments tested for AD today have failed to show any efficacy. There is a great need for therapies to prevent and/or slow the progression of AD. The major challenge in AD drug development is lack of clarity about the mechanisms underlying AD pathogenesis and pathophysiology. Several studies support the notion that AD is a multifactorial disease. While there is abundant evidence that amyloid plays a role in AD pathogenesis, other mechanisms have been implicated in AD such as tangle formation and spread, dysregulated protein degradation pathways, neuroinflammation, and loss of support by neurotrophic factors. Therefore, current paradigms of AD drug design have been shifted from single target approach (primarily amyloid-centric) to developing drugs targeted at multiple disease aspects, and from treating AD at later stages of disease progression to focusing on preventive strategies at early stages of disease development. Here, we summarize current strategies and new trends of AD drug development, including pre-clinical and clinical trials that target different aspects of disease (mechanism-based versus non-mechanism based, e.g. symptomatic treatments, lifestyle modifications and risk factor management).

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Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia

Abstract: Change history: In this Article, Extended Data Fig. 8 and Extended Data Table 1 contained errors, which have been corrected online.

Cited by 22 publications

References 0 publications

Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction

Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction

Navigating the translational roadblock: Towards highly specific and effective all-optical interrogations of neural circuits

Advances in developing novel therapeutic strategies for Alzheimer’s disease

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