Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens

Ismail, Ashrafali Mohamed; Cui, Tiange; Dommaraju, Kalpana; Singh, Gurdeep; Dehghan, Shoaleh; Seto, Jason; Shrivastava, Susmita; Fedorova, Nadia; Gupta, Neha; Stockwell, Timothy B.; Halpin, Rebecca; Heim, Albert; Kajon, Adriana E.; Romanowski, Eric G.; Kowalski, Regis P.; Malathi, Jambulingam; Therese, K Lily; Madhavan, H. N.; Zhang, Qiwei; Ferreyra, Leonardo; Jones, Mary Smith McCrory; Rajaiya, Jaya; Dyer, David W.; Chodosh, James; Seto, Donald

doi:10.1038/s41426-018-0200-4

Cited by 13 publications

(6 citation statements)

References 2 publications

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“…Even though genotype-specific primers targeting the hexon gene can be used successfully in the multiplex-PCR method for the detection and genotyping of HAdV in this study and in other studies ( 10 , 19 ), it has a limitation to be used for genotyping of HAdV recombinant strain. Homologous recombination is the main driver of genetic diversity and evolution of HAdV, especially the recombination between the hexon, penton base, and fiber genes ( 5 , 43 ). Conceivably, identification of HAdV genotype based only on the hexon gene sequence may lead to a wrong conclusion of HAdV genotype if it is the recombinant strain.…”

Section: Discussionmentioning

confidence: 99%

Diverse genotypes of human enteric and non-enteric adenoviruses circulating in children hospitalized with acute gastroenteritis in Thailand, from 2018 to 2021

Yodmeeklin,

Kumthip,

Ukarapol

et al. 2023

Microbiol Spectr

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Human adenovirus (HAdV) is a common viral pathogen that causes diarrhea in children worldwide. The aim of this study was to investigate the prevalence and genotype diversity of HAdV strains circulating in children admitted to the hospitals with acute gastroenteritis (AGE) in Chiang Mai, Thailand, from 2018 to 2021. A total of 1,790 stool samples were screened for HAdV by PCR method, and 80 (4.5%) were positive for HAdV. Of these, children under 5 years of age accounted for 90.0% of HAdV-positive cases with the highest infection rate at the age group of 48–60 months old. The infection rate was not significantly different between boys and girls. The HAdV infection was detected sporadically throughout the year without a discrete seasonal pattern. Five species of both enteric and non-enteric HAdVs (A, B, C, E, and F) with 10 different genotypes, including HAdV-F41 (25.0%), HAdV-B3 (17.5%), HAdV-F40 (16.3%), HAdV-C1 (15.0%), HAdV-C5 (7.5%), HAdV-C2 (6.3%), HAdV-B7 (5.0%), HAdV-A12 (3.8%), HAdV-E4 (2.5%), and HAdV-B11 (1.3%), were detected in this study. In conclusion, our study reported the prevalence and seasonality of HAdV infection with a wide variety of HAdV genotypes circulating in children hospitalized with AGE during a period of 2018–2021 in Chiang Mai, Thailand. IMPORTANCE In the present study, the prevalence of human adenovirus (HAdV) infection in children with acute gastroenteritis (AGE) in Chiang Mai, Thailand, from 2018 to 2021 was detected at 4.5%. Diverse species and genotypes of HAdVs (HAdV-A12, HAdV-B3, HAdV-B7, HAdV-B11, HAdV-C1, HAdV-C2, HAdV-C5, HAdV-E4, HAdV-F40, and HAdV-F41) had been identified. The highest infection rate was found in children aged 48–60 months old. The HAdV infection was detected sporadically throughout the year. These findings imply that a wide variety of HAdV genotypes circulate in pediatric patients with AGE in Chiang Mai, Thailand.

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Section: Discussionmentioning

confidence: 99%

Diverse genotypes of human enteric and non-enteric adenoviruses circulating in children hospitalized with acute gastroenteritis in Thailand, from 2018 to 2021

Yodmeeklin,

Kumthip,

Ukarapol

et al. 2023

Microbiol Spectr

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“…Their scalability and cost efficiency facilitated their rapid development and large-scale distribution as vectors for vaccines against SARS-CoV-2 ( Jacob-Dolan and Barouch, 2022 ). They have the advantage of large packaging capacity ( Ismail et al, 2018 ; Asmamaw Mengstie, 2022 ) and third generation vectors allow the delivery of large CRISPR cargo in one viral vector ( Brescia et al, 2020 ; Tasca et al, 2020 ). Because exposure to adenoviruses is common, pre-existing immunity is prevalent in the general population and cross-reactivity among different serotypes is frequently observed ( Lee et al, 2017 ).…”

Section: Considerations To Mitigate Immunogenicity For Clinical Trans...mentioning

confidence: 99%

Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation

Ewaisha

Anderson

2023

Front. Bioeng. Biotechnol.

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CRISPR offers new hope for many patients and promises to transform the way we think of future therapies. Ensuring safety of CRISPR therapeutics is a top priority for clinical translation and specific recommendations have been recently released by the FDA. Rapid progress in the preclinical and clinical development of CRISPR therapeutics leverages years of experience with gene therapy successes and failures. Adverse events due to immunogenicity have been a major setback that has impacted the field of gene therapy. As several in vivo CRISPR clinical trials make progress, the challenge of immunogenicity remains a significant roadblock to the clinical availability and utility of CRISPR therapeutics. In this review, we examine what is currently known about the immunogenicity of CRISPR therapeutics and discuss several considerations to mitigate immunogenicity for the design of safe and clinically translatable CRISPR therapeutics.

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“…Many studies support the hypothesis that homologous recombination plays an important role in the molecular evolution of HAdV 14 . A recent genomic analysis of 32 emerging HAdV pathogens has indicated that HAdV‐B is one of the species with the largest number of recombinant members 15 . Studies on HAdV‐C recombinant viruses have shown that there is a frequent exchange of genetic components between different genotypes 16 .…”

Section: Introductionmentioning

confidence: 96%

“…14 A recent genomic analysis of 32 emerging HAdV pathogens has indicated that HAdV-B is one of the species with the largest number of recombinant members. 15 Studies on HAdV-C recombinant viruses have shown that there is a frequent exchange of genetic components between different genotypes. 16 Novel HAdV resulting from recombination could lead to the outbreak of HAdV.…”

mentioning

confidence: 99%

Genome sequencing reveals molecular epidemiological characteristics and new recombinations of adenovirus in Beijing, China, 2014−2019

Li,

Kang

et al. 2023

Journal of Medical Virology

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To investigate the molecular epidemiological characteristics and genetic variations of human adenovirus (HAdV) in acute respiratory tract infections in Beijing. Whole‐genome sequencing and phylogenetic analyses were performed for 83 strains of HAdV with different types in Beijing from 2014 to 2019. The clinical characteristics of HAdV infection were analyzed statistically. HAdV‐B was divided into four genotypes, including B3 (n = 11), B7 (n = 13), B14 (n = 4), and B55 (n = 2). HAdV‐C was divided into three genotypes, including C1 (n = 14), C2 (n = 13), and C5 (n = 10). In HAdV‐C, nine recombinant adenovirus strains were identified in type 1, and seven recombinant strains were found in type 2. In type 1, we found three newly emerged intraspecific recombinant strains (A47, A48, and A52) collected in 2017, 2018, and 2019, respectively. In addition, the previously reported recombinant strains of HAdV‐C1 showed more severe disease than other strains of HAdV‐C, causing severe community‐acquired pneumonia in both the elderly and children. Continuous population‐wide molecular epidemiological surveillance of HAdV is essential for the prevention and control of respiratory infectious diseases.

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Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens

Cited by 13 publications

References 2 publications

Diverse genotypes of human enteric and non-enteric adenoviruses circulating in children hospitalized with acute gastroenteritis in Thailand, from 2018 to 2021

Diverse genotypes of human enteric and non-enteric adenoviruses circulating in children hospitalized with acute gastroenteritis in Thailand, from 2018 to 2021

Immunogenicity of CRISPR therapeutics—Critical considerations for clinical translation

Genome sequencing reveals molecular epidemiological characteristics and new recombinations of adenovirus in Beijing, China, 2014−2019

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