Author Correction: Gut-derived butyrate suppresses ocular surface inflammation

Schaefer, Laura; Hernandez, Humberto; Coats, Rosalind A; Yu, Zhiyuan; Pflugfelder, Stephen C.; Britton, Robert A.; Paiva, Cintia S. de

doi:10.1038/s41598-022-10856-y

Cited by 4 publications

(3 citation statements)

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“…PBA has been shown to reduce TNF- α transcript levels after LPS treatment in murine corneal cells but not human corneal cells. 29 Accordingly, we stimulated HCE cells with the bacterial endotoxin lipopolysaccharide (LPS) and found that it significantly increased the expression of TNF-α, IL-1β, IFN-α, and IFN-β ( Figures 4 A–4D). As with its efficacy in antagonizing TG and poly(I:C), PBA treatment reduced the cytokine transcripts produced post LPS addition ( Figures 4 A–4D).…”

Section: Resultsmentioning

confidence: 99%

Topical phenylbutyrate antagonizes NF-κB signaling and resolves corneal inflammation

Koganti¹,

Yadavalli²,

Sutar³

et al. 2022

iScience

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Section: Resultsmentioning

confidence: 99%

Topical phenylbutyrate antagonizes NF-κB signaling and resolves corneal inflammation

Koganti¹,

Yadavalli²,

Sutar³

et al. 2022

iScience

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“…Cultures from Slc5a8 knockout mice showed no response to pre-treatment with phenylbutyrate. Furthermore, the anti-inflammatory effect of butyrate in vivo was shown to partially require SLC5A8 (100).…”

Section: Short-chain Fatty Acidsmentioning

confidence: 96%

“…One study hypothesized butyrate produced in the gut also has a direct effect on the differentiation or maintenance of conjunctival goblet cells, lending to its role in dry eye disease (128). In a pharmacologic study, butyrate was shown to modulate the inflammatory responses at the ocular surface and, when delivered intragastrically, attenuated ocular surface disease in a dry eye disease mouse model through SCFA transporter SLC5A8 (100). In-vitro experiments showed the reduction of Tumor Necrosis Factor alpha (TNF alpha) expression in corneal epithelial cultures when pre-treated with phenylbutyrate.…”

Section: Short-chain Fatty Acidsmentioning

confidence: 99%

Unveiling the gut-eye axis: how microbial metabolites influence ocular health and disease

Nguyen,

Rudd Zhong Manis,

Ronczkowski

et al. 2024

Front. Med.

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The intricate interplay between the gut microbiota and ocular health has surpassed conventional medical beliefs, fundamentally reshaping our understanding of organ interconnectivity. This review investigates into the intricate relationship between gut microbiota-derived metabolites and their consequential impact on ocular health and disease pathogenesis. By examining the role of specific metabolites, such as short-chain fatty acids (SCFAs) like butyrate and bile acids (BAs), herein we elucidate their significant contributions to ocular pathologies, thought-provoking the traditional belief of organ sterility, particularly in the field of ophthalmology. Highlighting the dynamic nature of the gut microbiota and its profound influence on ocular health, this review underlines the necessity of comprehending the complex workings of the gut-eye axis, an emerging field of science ready for further exploration and scrutiny. While acknowledging the therapeutic promise in manipulating the gut microbiome and its metabolites, the available literature advocates for a targeted, precise approach. Instead of broad interventions, it emphasizes the potential of exploiting specific microbiome-related metabolites as a focused strategy. This targeted approach compared to a precision tool rather than a broad-spectrum solution, aims to explore the therapeutic applications of microbiome-related metabolites in the context of various retinal diseases. By proposing a nuanced strategy targeted at specific microbial metabolites, this review suggests that addressing specific deficiencies or imbalances through microbiome-related metabolites might yield expedited and pronounced outcomes in systemic health, extending to the eye. This focused strategy holds the potential in bypassing the irregularity associated with manipulating microbes themselves, paving a more efficient pathway toward desired outcomes in optimizing gut health and its implications for retinal diseases.

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