Author Correction: Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha

Nomura, Ryota; Inaba, Hiroaki; Yasuda, Hidemi; Shirai, Mitsuyuki; Kato, Yukio; Murakami, Masaru; Iwashita, Naoki; Shirahata, So; Yoshida, Sho; Matayoshi, Saaya; Yasuda, Junya; Arai, Nobuaki; Asai, Fumitoshi; Matsumoto‐Nakano, Michiyo; Nakano, Kazuhiko

doi:10.1038/s41598-020-63861-4

Cited by 4 publications

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“…It has been reported that P. gulae is susceptible to clindamycin, which has been approved for the treatment of periodontal disease in dogs ( 14 , 15 ). Recently, our group showed that combination therapy using clindamycin and IFN-α treatment can improve periodontal condition and reduce P. gulae in dogs ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, type C induces even higher systemic inflammation than the other genotypes ( 11 , 12 ). Indeed, type C is considered to be the most virulent of the genotypes, as it is predominant in the oral cavities of dogs with severe periodontitis ( 12 , 13 ). However, previous studies only demonstrated fimA Type C may be found more frequently in severe disease samples and have the ability to cause more inflammation than other types in a mouse model, this does not prove causation of periodontitis in dogs.…”

Section: Introductionmentioning

confidence: 99%

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Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Shirahata

Iwashita²,

Sasaki³

et al. 2023

Front. Vet. Sci.

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Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed to elucidate the association between fimA type of P. gulae with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by P. gulae fimA type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in P. gulae-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in P. gulae fimA type C-dominant dogs was significantly lower than that of P. gulae-negative dogs, suggesting there is a significant association between fimA type of P. gulae and the number of permanent teeth resulting from the development of periodontal disease.

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Section: Discussionmentioning

confidence: 99%