Author response for "High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2"

Vanhove, Bernard; Duvaux, Odile; Rousse, Juliette; Royer, Pierre-Joseph; Evanno, Gwénaëlle; Ciron, Carine; Lhériteau, Elsa; Vacher, Laurent; Gervois, Nadine; Oger, Romain; Jacques, Yannick; Conchon, Sophie; Salama, Apolline; Duchi, Roberto; Lagutina, Irina; Perota, Andrea; Delahaut, Philippe; Ledure, Matthieu; Paulus, Melody; So, Ray T.Y.; Mok, Chris K. P.; Bruzzone, Roberto; Bouillet, Marc; Brouard, Sophie; Cozzi, Emanuele; Galli, Cesare; Blanchard, Dominique; Bach, Jean-Marie; Soulillou, Jean‐Paul

doi:10.1002/eji.202049072/v2/response1

2021

DOI: 10.1002/eji.202049072/v2/response1

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Author response for "High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2"

Bernard Vanhove¹,

Odile Duvaux²,

Juliette Rousse³

et al.

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Scientific and technological approaches to improve SCNT efficiency in farm animals and pets

et al. 2021

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The birth of Dolly through somatic cell nuclear transfer (SCNT) was a major scientific breakthrough of the last century. Yet, while significant progress has been achieved across the technics required to reconstruct and in vitro culture nuclear transfer embryos, SCNT outcomes in terms of offspring production rates are still limited. Here we provide a snapshot of the practical application of SCNT in farm animals and pets. Moreover, we suggest a path to improve SCNT through alternative strategies inspired by the physiological reprogramming in male and female gametes in preparation for the totipotency required after fertilization. Almost all papers on SCNT focused on nuclear reprogramming in the somatic cells after nuclear transfer. We believe that this is misleading, and even if it works sometimes, it does so in an uncontrolled way. Physiologically, the oocyte cytoplasm deploys nuclear reprogramming machinery specifically designed to address the male chromosome, the maternal alleles are prepared for totipotency earlier, during oocyte nuclear maturation. Significant advances have been made in remodeling somatic nuclei in vitro through the expression of protamines, thanks to a plethora of data available on spermatozoa epigenetic modifications. Missing are the data on large-scale nuclear reprogramming of the oocyte chromosomes. The main message our article conveys is that the next generation nuclear reprogramming strategies should be guided by insights from in-depth studies on epigenetic modifications in the gametes in preparation for fertilization.

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Scientific and technological approaches to improve SCNT efficiency in farm animals and pets

et al. 2021

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Author response for "High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2"

Cited by 1 publication

References 0 publications

Scientific and technological approaches to improve SCNT efficiency in farm animals and pets

Scientific and technological approaches to improve SCNT efficiency in farm animals and pets

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