Autism and the Gut

Gilger, Mark A.; Redel, Carol A.

doi:10.1542/peds.2009-0741

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…Since 5-HT 4 -Rs play a major role in the development and physiology of the gut (Schworer and Ramadori, 1998;Mader et al, 2006;Liu et al, 2009) and they are also expressed in blood platelets (Amisten et al, 2008;Serebruany et al, 2009), 5-HT 4 -R abnormalities are also likely to lead to gastrointestinal and blood pathology. The comorbidity of ASDs and gastrointestinal problems has been often reported (Gilger and Redel, 2009), and the Since linear regression is likely to have more statistical power than ANOVA when the independent variable can be measured on a continuous scale (Lazic, 2008), the results of both analyses are given in the table.…”

Section: Discussionmentioning

confidence: 99%

Transient expression of serotonin 5‐HT₄ receptors in the mouse developing thalamocortical projections

Slaten

Hernandez

Albay

et al. 2010

Developmental Neurobiology

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The serotonin 5-HT(4) receptor (5-HT(4)-R) is an unusually complex G-protein coupled receptor that is likely to play important roles in brain development and that may underlie the comorbidity of central and peripheral abnormalities in some developmental disorders. We studied the expression of 5-HT(4)-Rs in the developing mouse forebrain at embryonic days 13, 15, 17, and at postnatal days 3 and 14 by using immunohistochemistry, tract tracing, and quantitative RT-PCR. The developing thalamocortical projections transiently expressed 5-HT(4)-Rs in the embryonic brain and the 5-HT(4)-R expression in the forebrain changed from axonal to somatic around birth. From embryonic days 13-17, the forebrain mRNA levels of the 5-HT(4(a))-R and 5-HT(4(b))-R splice variants increased nine- and fivefold, respectively, whereas the levels of the 5-HT(4(e))-R and 5-HT(4(f))-R variants remained relatively low throughout the studied period of embryonic development. These results suggest that during development 5-HT(4)-R expression undergoes a dynamic regulation and that this regulation may be important for the normal development of sensory and limbic processing.

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Section: Discussionmentioning

confidence: 99%

Transient expression of serotonin 5‐HT₄ receptors in the mouse developing thalamocortical projections

Slaten

Hernandez

Albay

et al. 2010

Developmental Neurobiology

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“…Gut-microbiome directed therapies, including fecal transplantation, may eventually translate into clinical improvement [105]. However, there is considerable controversies concerning published findings and future mechanistic research is certainly implicated [106][107][108][109].…”

Section: Critical Appraisalmentioning

confidence: 99%

Treating Autism Spectrum Disorder with Gluten-Free and Casein-Free Diet: The Underlying Microbiota-Gut-Brain Axis Mechanisms

Cieślińska

Kostyra

Savelkoul

2017

CIIT

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There is a rising interest in the use of dietary interventions to ameliorate prevalent brain diseases, including Autism Spectrum Disorder (ASD). Nowadays, the existence of communication between gut and brain is well accepted and thus diet can influence brain functioning. A well-known nutrition based intervention for ASD is the gluten-free and casein-free diet. However, only some of the patients experience a relief in symptoms and thus efficacy seems to be limited to certain phenotypes. However, not much is known about the mechanism of action through which this diet might work, or about interpersonal differences that could lead to variation in response to the diet. Current evidence for efficacy of the GFCF diet is poor. Large scale, good quality randomized controlled trials are needed. Genetic and environmentally induced interpersonal differences were found in intestinal membrane permeability and blood brain barrier integrity as well as in activity of peptidase enzymes. These differences probably affect responsiveness to the diet. In addition, age and duration of the dietary intervention play a role in the efficacy of the gluten-free and casein-free diet. This is the reason why all these factors need to be taken into account to give appropriate advice about whether or not to follow this diet.have extensive effects in the rest of the body through the Microbiota-Gut-Brain axis (MGB axis).Citation:

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“…Further research examining the potential role of the gut microbiome in autism has suggested that children with autism spectrum disorders have alterations in the composition and metabolism of their gut microbiota (De Angelis et al, 2013; Martirosian et al, 2011; Parracho et al, 2005; Song et al, 2004). It is important to note, however, that the causal role of the gut microbiota in autism spectrum disorders is unclear as these disorders are also associated with high levels of food selectivity, which may have an impact on the composition of the gut microbiome (Erickson et al, 2005; Gilger & Redel, 2009). A few small studies have provided preliminary support for the potential role of probiotics in alleviating both gastrointestinal symptoms as well as symptoms associated with autism spectrum disorders.…”

Section: Probiotics and Stress Reactivitymentioning

confidence: 99%

The gut microbiome: Potential innovations for the understanding and treatment of psychopathology.

Nowakowski

McCabe

Rowa

et al. 2016

Canadian Psychology / Psychologie canadienne

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The past decade has seen an increase in research examining the potential role of the microbiota-gut-brain axis in psychopathology. The microbiota-gut-brain axis involves bidirectional communication between the gut and the central nervous system. Although it is well-established that the central nervous system plays a role in the functioning of the gut, there is growing evidence that the gut also has an influence on the central nervous system. Studies using animal models have suggested that the microbiota-gut-brain axis may play a role in modulating the brain and behavior. The present article provides an overview of the preclinical evidence for the role of the microbiota-gut-brain axis in psychopathology and discusses the potential clinical implications for how we understand and treat psychiatric disorders. Moreover, future directions for research are identified.

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Autism and the Gut

Cited by 9 publications

References 23 publications

Transient expression of serotonin 5‐HT₄ receptors in the mouse developing thalamocortical projections

Transient expression of serotonin 5‐HT₄ receptors in the mouse developing thalamocortical projections

Treating Autism Spectrum Disorder with Gluten-Free and Casein-Free Diet: The Underlying Microbiota-Gut-Brain Axis Mechanisms

The gut microbiome: Potential innovations for the understanding and treatment of psychopathology.

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Autism and the Gut

Cited by 9 publications

References 23 publications

Transient expression of serotonin 5‐HT4 receptors in the mouse developing thalamocortical projections

Transient expression of serotonin 5‐HT4 receptors in the mouse developing thalamocortical projections

Treating Autism Spectrum Disorder with Gluten-Free and Casein-Free Diet: The Underlying Microbiota-Gut-Brain Axis Mechanisms

The gut microbiome: Potential innovations for the understanding and treatment of psychopathology.

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Product

Resources

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Transient expression of serotonin 5‐HT₄ receptors in the mouse developing thalamocortical projections

Transient expression of serotonin 5‐HT₄ receptors in the mouse developing thalamocortical projections