Autism Diagnostic Interview

Couteur, Ann Le; Rutter, Michael; Lord, Catherine; Rios, Patricia; Robertson, Sarah; Holdgrafer, M; McLennan, John D.

doi:10.1037/t49977-000

Cited by 136 publications

(155 citation statements)

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“…All subjects were assessed to confirm diagnostic group and parents completed standardized interviews and questionnaires about their children’s past history and present behavior and functioning. Diagnosis of ASD was confirmed in all subjects by the Autism Diagnostic Interview-Revised (ADI-R) (Le Couteur et al, 1993) and the Autism Diagnostic Observation Schedules (ADOS) (Lord et al, 2003). Details have been described previously (Hertz-Picciotto et al, 2006) in which children that met full criteria for autism on both the ADI-R and ADOS were classified as autism (AU), and children that came within two points of meeting criteria for autism on the communications or social domains of the ADI-R and met criteria on ADOS were classified as ASD.…”

Section: Methodsmentioning

confidence: 99%

Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development

Chaidez

Hansen

Hertz‐Picciotto

2013

J Autism Dev Disord

424

328

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SCIENTIFIC ABSTRACT Objectives To compare GI problems among children with: 1) autism spectrum disorder (ASD), 2) developmental delay (DD) and 3) typical development (TD). Methods In 960 children from the CHildhood Autism Risks from Genetics and the Environment (CHARGE) study, we assessed GI symptom frequency. We examined scores on five Aberrant Behavior Checklist subscales comparing ASD children with high vs. low frequency GI symptoms. Results Compared to TD children, those with ASD (aOR 7.92[4.89–12.85]) and DD (aOR 4.55 [2.51–8.24]) were more likely to have at least one frequent GI symptom. Restricting to ASD children, those with frequent abdominal pain, gaseousness, diarrhea, constipation or pain on stooling scored worse on Irritability, Social Withdrawal, Stereotypy, and Hyperactivity compared with children having no frequent GI symptoms. Conclusions Frequent GI problems affect young children with ASD and DD more commonly than those with TD. Maladaptive behaviors correlate with GI problems, suggesting these comorbidities require attention.

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Section: Methodsmentioning

confidence: 99%

Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development

Chaidez

Hansen

Hertz‐Picciotto

2013

J Autism Dev Disord

424

328

View full text Add to dashboard Cite

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“…Risk of telescoping was reduced in the current sample due to the young and restricted ages of children at the time of the ADI-R (toddler research version; Le Couteur, Rutter, Lord, & DiLavore, 2006; see Lord, Shulman, DiLavore, 2004). We hypothesized that ages of language milestones would predict levels of ability and rates of change for language, nonverbal cognition, and adaptive skills.…”

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confidence: 85%

Brief Report: Ages of Language Milestones as Predictors of Developmental Trajectories in Young Children with Autism Spectrum Disorder

Kover

Edmunds

Weismer

2016

J Autism Dev Disord

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Recognizing early risk markers in young children with autism spectrum disorder (ASD) is critical for timely diagnosis and intervention. The purpose of this study was to extend previous findings regarding language milestones to a longitudinal design, in which ages of expressive language milestones (i.e., first words, first phrases) could serve as predictors of developmental trajectories in a heterogeneous sample of young children with ASD (N=98; age at first assessment: M=32 months, SD=5). Age of first words predicted trajectories of expressive language and adaptive skills; number of words predicted each outcome examined. Because these aspects of early language show promise as potential indicators of later functional outcomes, future research on developmental processes as they relate to individual differences will be particularly informative.

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“…The diagnosis of ASD was based on the Autism Diagnostic Observation Schedule 19 and the Autism Diagnostic Interview—Revised. 20 All other children were screened on the Social Communication Questionnaire, and those scoring at or above the cutoff were then assessed using the ADI-R and Autism Diagnostic Observation Schedule. A diagnosis of typical development was assigned to general population controls based on the Social Communication Questionnaire and composite scores of 70 or higher for the Mullen Scales of Early Learning 21 and the Vineland Adaptive Behavioral Scales.…”

Section: Methodsmentioning

confidence: 99%

Autism-specific maternal autoantibodies recognize critical proteins in developing brain

Krakowiak²,

et al. 2013

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Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls. ASD children from mothers with specific reactivity to LDH, STIP1 and CRMP1 and/or cypin (7% vs 0% in controls; P<0.0002; odds ratios of 24.2 (95% confidence interval: 1.45–405)) had elevated stereotypical behaviors compared with ASD children from mothers lacking these antibodies. We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism.

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Autism Diagnostic Interview

Cited by 136 publications

References 0 publications

Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development

Gastrointestinal Problems in Children with Autism, Developmental Delays or Typical Development

Brief Report: Ages of Language Milestones as Predictors of Developmental Trajectories in Young Children with Autism Spectrum Disorder

Autism-specific maternal autoantibodies recognize critical proteins in developing brain

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