Autism Spectrum Disorder Symptoms and Comorbidity in Emerging Adults

Gadke, Daniel L.; McKinney, Cliff; Oliveros, Arazais

doi:10.1007/s10578-015-0556-9

Cited by 25 publications

(7 citation statements)

References 25 publications

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“…Among internalizing disorders, comorbid anxiety disorders in individuals with ASD have been most extensively studied [35] and co-occur at higher rates in the ASD population than in populations without ASD symptoms [36,37] and non-ASD psychiatric referred populations [34]. Mood or depressive disorders also are shown to co-occur in individuals with autism at greater rates than the general population [28,32].…”

Section: Comorbid Psychopathologymentioning

confidence: 99%

Comparison of self-and other-report of symptoms of autism and comorbid psychopathology in adults with autism spectrum disorder

Pearl¹,

Edwards²,

Murray³

2017

Contemp Behav Health Care

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While the presentation of autism-related symptoms is variable across individuals with ASD, there is growing evidence that many of these symptoms may be further complicated or exacerbated by comorbid symptoms of psychopathology. Some individuals with ASD may also have difficulty reflecting and reporting on their own behavioral and emotional symptoms, which can interfere with diagnosis and treatment. The current study compared self-and other-ratings of the behavior of 47 young adults with ASD in the home environment, to identify areas of rater agreement and discrepancy across symptoms of both ASD and general pathology. For ASD symptoms, nominated reporters rated the participant's behavior as significantly more impaired regarding social communication symptoms, but no significant difference was found for restricted and repetitive behavior. For symptoms of psychopathology, only attention problems, depression problems, avoidant personality problems, and total problems were reported by others as significantly higher when compared to self-report. While this provides increased confidence for assessing most comorbid symptoms of psychopathology via one reporter, results suggest obtaining collateral reports for ASD symptoms may be important for comprehensive assessment. The results from this study may inform the future of the clinical field regarding the use of a more efficient assessment of individuals with ASD's behavior and comorbid psychopathology.

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Section: Comorbid Psychopathologymentioning

confidence: 99%

Comparison of self-and other-report of symptoms of autism and comorbid psychopathology in adults with autism spectrum disorder

Pearl¹,

Edwards²,

Murray³

2017

Contemp Behav Health Care

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“…[29][30][31][32] Few studies focused on physical disorders, [33][34][35] and fewer still focused on adults. 36 In this study, the physical comorbidities associated with ASD and the main disorder classes from the International Classification of Diseases, Ninth Revision (ICD-9) were examined in a population including children and adults.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Description of Comorbidity for Autism Spectrum Disorder in a General Population

Cawthorpe

2017

TPJ

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Context: Few published studies of autism spectrum disorder (ASD) and comorbidity are population based.Objective: To describe the comorbidity of ASD and disorders listed in the main classes of the International Classification of Diseases, Ninth Revision (ICD-9) in a general population.Design: Direct physician billing data for the city of Calgary, Alberta, Canada, for the treatment of any presenting concern in the Calgary Health Zone (n = 763,449) from 1994 to 2009 were extracted. Diagnosed ICD-9 disorders (independent variable) were grouped into 17 categories using ICD-9 diagnosis codes. ASD (dependent variable) was classified under ICD-9 Code 299. Individuals with and without independent disorder classes were counted by the presence or absence of any ASD. Odds ratios (ORs) and 95% confidence intervals of the association were calculated.Main Outcome Measures: ORs of ASD comorbidities. Results: Annual rates of ASD increased 3.9-fold for males and 1.4-fold for females. Diagnosed disorders ranked by OR in the independent ICD-9 categories indicated that males with ASD had overall higher ORs (> 1.0) in 11 main ICD-9 classes, and females with ASD had higher ORs (> 1.0) in 12 main ICD-9 classes. Males with ASD had lower ORs in 4 main ICD-9 disease classes; females with ASD had lower ORs related only to the main class "complications of pregnancy and childbirth." Five main ICD-9 classes were not significant for males or females.Conclusions: Patients with ASD have significant comorbidity of physical disorders. This finding may inform other areas of research and assessment in clinical management.

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“…Idiopathic (nonsyndromic) ASD, for which an underlying cause has not been identified, represent the majority of cases. Individuals with ASD traced to either single-gene mutations or defined chromosomal/cytogenetic abnormalities (syndromic autism) exhibit characteristic features that are often accompanied by additional comorbidities [ 3 , 4 ]. Genetically defined syndromic disorders which phenotypically overlap with ASD include Rett, Fragile X, Tuberous sclerosis, Asperger’s, Smith–Lemli–Opitz syndromes, 22q11.2del, etc.…”

mentioning

confidence: 99%

Merging Data from Genetic and Epigenetic Approaches to Better Understand Autistic Spectrum Disorder

Grayson

Guidotti

2015

Epigenomics

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is characterized by a wide range of cognitive and behavioral abnormalities. Genetic research has identified large numbers of genes that contribute to ASD phenotypes. There is compelling evidence that environmental factors contribute to ASD through influences that differentially impact the brain through epigenetic mechanisms. Both genetic mutations and epigenetic influences alter gene expression in different cell types of the brain. Mutations impact the expression of large numbers of genes and also have downstream consequences depending on specific pathways associated with the mutation. Environmental factors impact the expression of sets of genes by altering methylation/hydroxymethylation patterns, local histone modification patterns and chromatin remodeling. Herein, we discuss recent developments in the research of ASD with a focus on epigenetic pathways as a complement to current genetic screening.

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Autism Spectrum Disorder Symptoms and Comorbidity in Emerging Adults

Cited by 25 publications

References 25 publications

Comparison of self-and other-report of symptoms of autism and comorbid psychopathology in adults with autism spectrum disorder

Comparison of self-and other-report of symptoms of autism and comorbid psychopathology in adults with autism spectrum disorder

Comprehensive Description of Comorbidity for Autism Spectrum Disorder in a General Population

Merging Data from Genetic and Epigenetic Approaches to Better Understand Autistic Spectrum Disorder

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