Autism Spectrum Disorders and Epigenetics

Grafodatskaya, Daria; Chung, Brian Hon‐Yin; Szatmári, Péter; Weksberg, Rosanna

doi:10.1016/j.jaac.2010.05.005

Cited by 205 publications

(147 citation statements)

References 177 publications

(206 reference statements)

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“…central coherence, brain structure anomalies, cytogenetic abnormalities, and single-gene defects, toxic exposures, teratogens, measles-mumps-rubella vaccines, some prenatal, obstetric and neonatal factors and etc have been specified as the contributing factors in the etiologies of ASDs in the different researches across the world (7,(38)(39)(40)(41)(42)(43)(44). The relationships between ASDs and some effective factors have been investigated in Iran.…”

mentioning

confidence: 99%

Autism Spectrum Disorders in Iran

Mohammadi¹,

Salmanian²,

Akhondzadeh³

2011

A Comprehensive Book on Autism Spectrum Disorders

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mentioning

confidence: 99%

Autism Spectrum Disorders in Iran

Mohammadi¹,

Salmanian²,

Akhondzadeh³

2011

A Comprehensive Book on Autism Spectrum Disorders

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“…Finally, several lines of evidence suggest that epigenetics plays an important role in ASD etiology, and it might integrate genetic and environmental influences to dysregulate neurodevelopmental processes (Grafodatskaya et al 2010;Hall and Kelley 2013). Research in this field not only provides more insight into the complex gene interactions in autism but also makes contributions to clinical aspects of ASDs.…”

Section: Discussionmentioning

confidence: 99%

“…Epigenetic mechanisms (e.g., DNA methylation, histone modifications, and expression of non-coding microRNAs) produce heritable modifications in gene expression without changes in DNA sequence (Chuang and Jones 2007;Cedar and Bergman 2009;Svoboda and Flemr 2010). "Environmental epigenomics" is thus defined as the constant interplay between the environment, which include both endogenous (such as hormones) and exogenous factors (such as chemicals and food) and the epigenome (Grafodatskaya et al 2010;Gorini et al 2014).…”

mentioning

confidence: 99%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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“…Causal contributions to the manifestation of pervasive developmental disorders may be classified into six categories: biological etiology, neurobiological factors, neurochemical factors, pre-and perinatal conditions, environmental and comorbidity factors. Accordingly, the underlying etiological mechanisms responsible for the manifestation of complex autistic behaviors are by nature multifactorial and include disproportionately unknown unregulated genetic, developmental, and environmental components [114,115]. Preferential evidence favoring genetically driven etiological factors is compelling, is inherently complex, but perhaps underestimates the contribution of environmental determinants [116,117].…”

Section: Co-morbidity Indicative Factorsmentioning

confidence: 99%

Autism-A Multifaceted Diffuse Pathology

Brejlova¹,

Domkarova²,

Stefano³

2015

J Psychiatry

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Journal of Psychiatry AbstractThe causes of pervasive developmental disorders have yet to be resolved. Needless to say, the etiology is complex as are the individual factors, especially in regard to autism. Certain findings may be integrated into early coherent models, but the heterogeneity of findings remains a central feature of autism. The present review examines contemporary areas of research and a few prominent theories specifically dealing with autism. The areas under scrutiny are divided into common academic compartments, such as biological, environmental. Autism represents a very timely topic due to its rising incidence in the population as well as changes in previous concepts occurring at this time. Besides the neurological, biological and epidemiological factors contributing and possibly initiating this disorder we discuss the possible involvement of endogenous morphine, especially in regard to depression and limbic functions. Lastly, we advance the theory that dysfunctional mitochondria appear to be involved in autism as well, explaining the widespread occurrence of its characteristics within the construct of susceptibility to stress and trauma. Thus, the diffuse manifestations of Pervasive Developmental Disorder occur potentially by altering energy processes.

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Autism Spectrum Disorders and Epigenetics

Cited by 205 publications

References 177 publications

Autism Spectrum Disorders in Iran

Autism Spectrum Disorders in Iran

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Autism-A Multifaceted Diffuse Pathology

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