Autism spectrum disorders: etiology, treatment. models and experimental studies

Lavrov, Nikanor V.; Васильевич, Лавров Никанор; Shabanov, Petr D.; Дмитриевич, Шабанов Петр

doi:10.17816/rcf16121-27

Cited by 4 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic and environmental influences are often correlated with ASD [1]. Research indicates that there is no widely recognized definition of the existence of ASD, and the lack of appropriate therapeutic options makes it necessary to consider ASD as an incurable condition at present [2]. Moreover, the proper diagnosis of ASD requires daily evaluation and behavior review [3].…”

Section: Introductionmentioning

confidence: 99%

Validation non-English version of modified checklist for autism in toddlers-revised with follow-up

et al. 2021

View full text Add to dashboard Cite

Background: In modern conditions, the diagnosis of autism spectrum disorders (ASD) in young children is quite complex. A two-step version of the updated checklist for autism in young children, revised with follow-up (M-CHAT-R/F), was shown to be successful in a large, geographically diverse sample of young children in primary care. In this study, the authors conducted a critical study of 16 validation studies of 35,722 participants participating in M-CHAT-R/F for early detection of ASD in non-English-speaking countries, and established a recommendation for validation of the non-English-language version of the M-CHAT-R/F screening method among toddlers.Aim: Examine available publications on assessing the accuracy of the screening tool for detecting ASD in non-English speaking countries and identify possible errors in methodology.Material and methods: The survey was conducted in databases. The criteria for inclusion of publications in this review: studies of the diagnostic accuracy of the screening tool for early detection of ASD M-CHAT-R/F, non-English speaking country of study. The search depth is 6 years.Results: The sensitivity and accuracy of M-CHAT-R/F screening displayed outstanding performance with an average of 0.86 (CI=0.95) and 0.80 (CI=0.95) respectively. Based on the findings of this analysis, it can be inferred that, at some stage of the assessment of the validity and reliability of the M-CHAT-R/F instrument, each study included in the analysis rendered various degrees of error.Conclusion: Non-compliance with the blindness guideline and the presence of children diagnosed with ASD and documented screening outcomes greatly raises the likelihood of error. A major challenge for researchers at the timing and flow stage was to ensure that the maximum number of participants participated from the very beginning to the end. It is more effective for researchers to work with a sample of small magnitude since this is an incentive to offer diagnostics to the full number of study participants.

show abstract

Section: Introductionmentioning

confidence: 99%

Validation non-English version of modified checklist for autism in toddlers-revised with follow-up

et al. 2021

View full text Add to dashboard Cite

show abstract

Models of Autism and Methods for Assessing Autistic-Like Behavior in Animals

Семенова

Lopatina

Салмина

2020

Neurosci Behav Physi

View full text Add to dashboard Cite

Dynamics of the Markers to the Central Nervous System Damage in the Treatment of Patients with Autism

Dokukina,

Golubeva,

Lapysh

2024

Autism and Developmental Disorders

View full text Add to dashboard Cite

Objectives. Studies to identify serologic markers of the nature of protein associated with the development of autism spectrum disorders are relevant for the improvement of diagnostic methods. The relationship between the quantitative content of phosphorylated tau protein and light chains of neurofilaments in the blood of children with autism and changes in the clinical picture of the disease during therapeutic interventions was revealed. Methods. Children aged from 3 to 12 years with diagnoses: infantile autism — 23 children; impaired psycho-verbal development due to organic brain damage — 34; conditionally healthy children — 15 people were studied. Anamnestic data was collected, an objective examination was conducted, and medical records were analyzed. The study utilized: the Denver Developmental Screening Test, the Childhood Autism Rating Scale (CARS); Human Tau [pT181] phosphoELISA Kit system test (KHO0631, USA), as well as the Human Neurofilament-Light Chain (NFL) ELISA Kit (EiAab, USA) for the quantitative determination of the phosphorylated isoform of tau protein and light chains of neurofilaments in blood samples by enzyme-linked immunoassay. The statistical processing of data was performed using the MannWhitney, Kruskal-Wallis, and Wilcoxon tests. Qualitative features were analyzed using Fisher’s criterion. Results. When studying the quantitative content of phosphorylated tau protein in the blood plasma and neurofilament light chains in the blood serum over time in 18 patients with autism, a significant decrease in the content of phosphorylated tau protein (p < 0.001, Wilcoxon test) and neurofilament light chains (p = 0.007, Wilcoxon test) was revealed when prescribing pathogenetic treatment with a positive effect from therapy. An example of a clinical case is presented. Conclusions. It is shown that the determination of the quantitative content of markers of central nervous system damage in blood can be used to assess changes in the functional state of its neuronal and axonal apparatus under the influence of therapy in children with autism. It is possible to further develop the research using the results obtained in the comparison of clinical, neuropsychological and biochemical indicators in assessing the dynamics of the clinical picture of the disease.

show abstract

Autism spectrum disorders: etiology, treatment. models and experimental studies

Cited by 4 publications

References 40 publications

Validation non-English version of modified checklist for autism in toddlers-revised with follow-up

Validation non-English version of modified checklist for autism in toddlers-revised with follow-up

Models of Autism and Methods for Assessing Autistic-Like Behavior in Animals

Dynamics of the Markers to the Central Nervous System Damage in the Treatment of Patients with Autism

Contact Info

Product

Resources

About